MPV和PDW在骨髓增生异常综合征中的临床意义

Clinical Significance of MPV and PDW in Myelodysplastic Syndrome

摘要: 目的：研究血小板参数——平均血小板体积(Mean platelet volume, MPV)、血小板分布宽度(Platelet distribution width, PDW)在骨髓增生异常综合征(Myelodysplastic syndrome, MDS)病人诊断中的意义。方法：回顾性分析2015年6月至2020年10月在潍坊医学院附属医院34例MDS病人的临床资料。绘制ROC曲线并计算曲线下面积、最佳临界值(Cutoff值)、敏感度和特异性。结果：MDS患者的MPV、PDW均显著高于对照组，差异具有统计学意义。采用ROC曲线分析得出：MPV曲线下面积70.3%，最佳临界值为9.95 fl，最佳临界值处的敏感性和特异性分别为61.8%和85.7%。PDW曲线下面积78.9%，最佳临界值为16.55 fl，最佳临界值处的敏感性和特异性分别为67.6%和82.9%。结论：MPV/PDW在MDS中具有诊断意义，可作为MDS的筛查及诊断指标之一。

Abstract: Objective: To discuss the significance of platelet parameters-mean platelet volume (MPV) and platelet distribution width (PDW) in the diagnosis of myelodysplastic syndrome. Method: A retrospective analysis of the clinical data of 34 MDS patients in the Affiliated Hospital of Weifang Medical College from June 2015 to October 2020. Draw the ROC curve and calculate the area under the curve, the best cutoff value (Cutoff value), sensitivity and specificity. Results: The MPV/PDW of MDS group was higher than that of the normal control group; the difference was statistically significant (P < 0.05). The area under the curve (AUC) of MPV was 0.703 (P < 0.01). The cutoff value of MPV was 9.95 fl. The sensitivity and specificity of MPV for MDS diagnosis were 61.8% and 85.7%. The area under the curve (AUC) of PDW was 0.789 (P < 0.01). The cutoff value of MPV was 16.55 fl. The sensitivity and specificity of PDW for MDS diagnosis were 67.6% and 82.9%. Conclusion: MPV/PDW has diagnostic significance in MDS and can be used as one of the screening and diagnostic indicators of MDS.