合并便秘的帕金森病人血清尿酸、同型半胱氨酸水平分析

Analysis of Serum Uric Acid and Homocysteine Levels in Parkinson’s Patients with Constipation

摘要: 目的：为研究血清尿酸(UA)、同型半胱氨酸(Hcy)与帕金森病(PD)合并便秘之间的关系。方法：选择从2020年5月~2021年1月于青岛大学附属医院门诊就诊的109例帕金森病，设为PD组，并根据患者现病史描述是否便秘，将PD组分为便秘组与非便秘组。并选取同期在本院105名体检健康者设为对照组。1) 分析血尿酸、血同型半胱氨酸水平与帕金森病的相关性。2) 分析合并RBD的帕金森病患者与这两项血清指标可能的联系。结果：1) PD组与正常对照组相比，两组UA、Hcy水平有差异，差异有统计学意义(P < 0.05)；2) 便秘组与非便秘组UA水平比较差异无统计学意义，便秘组Hcy水平高于非便秘组，差异有统计学意义(P < 0.05)；3) 帕金森病的严重程度与尿酸水平呈负相关，与同型半胱氨酸成正相关，差异有统计学意义(P < 0.05)；4) Hcy对便秘的诊断效能为：(AUC = 0.661, 95% CI = 0.556~0.767, P < 0.05)，其灵敏性和特异性分别为：58.3%，75.4%。结论：血清尿酸、同型半胱氨酸与帕金森病的发病有一定的相关性，且帕金森病病的严重程度与尿酸水平呈负相关，与同型半胱氨酸成正相关。同型半胱氨酸可能成为PD合并便秘的新的生物标志物。

Abstract: Objective: To study the relationship between serum uric acid (UA), homocysteine (Hcy) and Parkinson’s disease (PD) combined with constipation. Methods: 109 cases of Parkinson’s disease who were treated in the outpatient clinic of Qingdao University Hospital from May 2020 to January 2021 were selected as the PD group. According to the patient’s current medical history, the PD group was divided into the constipation group and the non-constipation group. And 105 healthy people were selected in our hospital during the same period as the control group. 1) Analyze the correlation between blood uric acid, blood homocysteine levels and Parkinson’s disease. 2) Analyze the possible relationship between these two serum indexes in Parkinson’s disease patients with RBD. Results: 1) Compared with the normal control group, the UA and Hcy levels of the two groups were different in the PD group, and the difference was statistically significant (P < 0.05); 2) There was no significant difference in the UA level between the constipation group and the non-constipation group. The Hcy level of the constipation group was higher than that of the non-constipation group, and the difference was statistically significant (P < 0.05); 3) The severity of Parkinson’s disease was negatively correlated with the level of uric acid, and positively correlated with homocysteine. There was statistical significance (P < 0.05); 4) The diagnostic efficiency of Hcy for constipation is: (AUC = 0.661, 95% CI = 0.556~0.767, P < 0.05), and its sensitivity and specificity are 58.3% and 75.4%, respectively. Conclusion: Serum uric acid and isotype cysteine have a certain correlation with the onset of Parkinson’s disease, and the severity of Parkinson’s disease is negatively correlated with uric acid levels and positively correlated with homocysteine. Homocysteine may become a new biomarker of PD with constipation.