缺血性脑卒中患者视网膜神经纤维层厚度的改变
Changes of Retinal Nerve Fiber Layer Thickness in Patients with Ischemic Stroke
摘要: 目的：探讨缺血性脑卒中患者视乳头周围视网膜神经纤维层(Retinal nerve fiber layer, RNFL)厚度的改变情况。方法：选取神经内科诊断明确的缺血性脑卒中患者60例(120眼)，将其分为2组：新发脑卒中组(第一次发生缺血性脑卒中) (32例，64眼)和既往脑卒中组(缺血性脑卒中发病后1~2年) (28例，56眼)。选取25例(50眼)健康人作为正常对照组。研究对象均行光学相干断层成像(optical coherence tomography, OCT)检查，测量视乳头周围RNFL厚度。结果：既往脑卒中组的平均RNFL厚度、上方RNFL厚度、鼻侧RNFL厚度、7时区RNFL厚度以及11时区RNFL厚度与对照组和新发脑卒中组相比差异有统计学意义(P < 0.05)；且既往脑卒中组的7时区RNFL厚度以及11时区RNFL厚度与新发脑卒中组相比差异有统计学意义(P < 0.05)；新发脑卒中组、既往脑卒中组的颞侧RNFL厚度以及8时区RNFL厚度与对照组相比差异有统计学意义(P < 0.05)；既往脑卒中组的10时区RNFL厚度与对照组和新发脑卒中相比差异有统计学意义(P < 0.05)。结论：缺血性脑卒中发病一段时间后，一些象限的视乳头周围RNFL厚度会变薄，且随着时间进展，变薄的趋势更明显。
Abstract: Aim: To discuss the changes of retinal nerve fiber layer (Retinal nerve fiber layer, RNFL) thickness in patients with ischemic stroke. Methods: Sixty patients with ischemic stroke (120 eyes) diagnosed by neurology were selected and divided into two groups: new stroke group (First ischemic stroke) (32 cases, 64 eyes) and previous stroke group (1~2 years after ischemic stroke) (28 cases, 56 eyes). 25 (50 eyes) healthy people were selected as control group. All subjects underwent optical coherence tomography (optical coherence tomography, OCT) to measure the thickness of retinal nerve fiber layer around the optic papilla. Results: The average RNFL thickness, superior RNFL thickness, nasal RNFL thickness, 7 clock-hour sector and 11 clock-hour sector in the previous stroke group were significantly different from those of the control group and the new stroke group (P < 0.05); 7 clock-hour sector and 11 clock-hour sector in the previous stroke group were significantly different from those of the new stroke group (P < 0.05); the thickness of the RNFL in the temporal and 8 clock-hour sector of the new stroke group and the previous stroke group were significantly different from those of the control group (P < 0.05); the thickness of the RNFL in the 10 clock-hour sector of the previous stroke group was significantly different from those of the control group and the new stroke group (P < 0.05). Conclusion: After a period of ischemic stroke, RNFL thickness around the papilla in some quadrants becomes thinner, and the trend is more pronounced over time.
文章引用：李颖颖, 冯洁, 李伟, 丁天娇. 缺血性脑卒中患者视网膜神经纤维层厚度的改变[J]. 临床医学进展, 2021, 11(4): 1531-1536. https://doi.org/10.12677/ACM.2021.114219

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