青岛地区男性人乳头瘤病毒基因型分布
Distribution of Human Papillomavirus Genotypes in Men in Qingdao
DOI: 10.12677/ACM.2021.114222, PDF,    科研立项经费支持
作者: 马祥钰, 江 水, 许璐璐, 陈官芝：青岛大学附属医院市南院区皮肤科，山东 青岛
关键词: 人乳头瘤病毒；男性；基因型分布；Human Papillomavirus； Men； Genotypic Distribution
摘要: 背景：高危型人乳头瘤病毒(HR-HPV)是宫颈癌的主要病因，它对男性患者尤其是免疫缺陷者也具有致癌作用。生殖器HPV主要通过性传播感染，了解HPV亚型分布对于预防和阻断女性HPV感染也具有重要意义。我们对青岛地区门诊男性就诊者的HPV基因型分布进行了研究。方法：对2019年1月至2020年12月在青岛地区门诊就诊的男性患者(≥18岁) HPV检验结果进行分析。多重实时定量聚合酶链反应(QPCR)检测了17种高危型HPV (HR-HPV)基因型和6种低危型HPV (LR-HPV)基因型。结果：在1162名参与者中，425名患者被诊断为尖锐湿疣(CA)，737名患者为无症状男性。HPV总感染率为35.7% (415/1162)，HR-HPV阳性率为20.7% (241/1162)。HPV52 (9.2%，107/1162)是最常见的HR-HPV基因型，其次是HPV16 (8.8%，102/1162)、51 (6.1%，71/1162)、53 (5.7%，66/1162)。基因型16、52、51、59和66在CA患者中最常见。在我们所评估的地区，九价HPV预防性疫苗覆盖的31、33和45基因型的流行率较低。结论：HPV52、16、51、53和59是青岛地区男性最常见的HR-HPV基因型。值得关注的是，HPV51、53和59目前不在四价或九价HPV疫苗的覆盖范围内。
Abstract: Background: High-risk human papillomavirus (HR-HPV) is the main cause of cervical cancer, and it can also cause cancer in men, especially in patients with immunodeficiency. Genital HPV is mainly transmitted through sexual transmission. Understanding the distribution of HPV subtypes is also of great significance to prevent and block female HPV infection. We studied the distribution of HPV genotypes in men with HPV infection in Qingdao. Methods: The HPV test results of male patients (≥ 18 years old) in outpatients in Qingdao area from January 2019 to December 2020 were analyzed. Seventeen high-risk HPV (HR-HPV) genotypes and six low-risk HPV (LR-HPV) genotypes were detected by multiplex real-time quantitative polymerase chain reaction (PCR). Results: Among the 1162 participants, 425 were diagnosed with condyloma acuminatum (CA), and 737 patients were asymptomatic males. The total infection rate of HPV was 35.7% (415/1162), and the positive rate of HR-HPV was 20.7% (241/1162). HPV52 (9.2%, 107/1162) is the most common HR genotype, followed by HPV16 (8.8%, 102/1162), 51 (6.1%, 71/1162), and 53 (5.7%, 66/1162). Genotypes 16, 51, 52, 59 and 66 are the most common in patients with CA. In the evaluated area, the prevalence of 31, 33 and 45 genotypes covered by 9-valent HPV prophylactic vaccine was lower. Conclusion: HPV52, 16, 51, 53 and 59 are the most common HR genotypes in men in Qingdao. It is worth noting that HPV 51, 53 and 59 are not currently covered by 4-valent or 9-valent HPV vaccines.
文章引用：马祥钰, 江水, 许璐璐, 陈官芝. 青岛地区男性人乳头瘤病毒基因型分布[J]. 临床医学进展, 2021, 11(4): 1551-1557. https://doi.org/10.12677/ACM.2021.114222

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