肝内巨噬细胞在代谢相关脂肪性肝病中的研究进展
Research Progress of Intrahepatic Macrophages in Metabolism-Related Fatty Liver Disease
DOI: 10.12677/ACM.2021.114231, PDF,    国家自然科学基金支持
作者: 廖 凯：重庆市公共卫生医疗救治中心平顶山院区，重庆；杨 连, 龚建平：重庆医科大学附属第二医院，重庆
关键词: 巨噬细胞；代谢相关脂肪性肝病；治疗；综述；Macrophages； Metabolism Associated Fatty Liver Disease； Therapy； Review
摘要: 目的：总结肝内巨噬细胞与代谢相关脂肪性肝病的发生及治疗的研究进展。方法：通过阅读近几年国内外的相关文献，肝内巨噬细胞与代谢相关脂肪性肝病的发生及治疗的研究进展进行归纳总结。结果：近年研究表明，肝内单核巨噬细胞组成和功能变化是代谢相关脂肪性肝病进展的关键，单核巨噬细胞在疾病发展中的作用至关重要。结论：代谢相关脂肪性肝病仍是慢性肝病中的关注重点，在代谢相关脂肪性肝病发病中关于单核巨噬细胞的功能作用和组成变化已取得一定进展，为代谢相关脂肪性肝病的治疗提供了新思路。
Abstract: Objective: To summarize the research progress in the occurrence and treatment of macrophage and metabolic associated fatty liver disease (MAFLD). Methods: The research progress in the occurrence and treatment of macrophage and MAFLD was summarized by reading the domestic and international literatures published in recent years. Results: Recent studies have shown that the changes of the composition and function of monocytes/macrophages in the liver are the key to the progression of MAFLD, and the role of mononuclear macrophages in the development of the disease is very important. Conclusions: MAFLD is still the focus of chronic liver disease. Some progress has been made in the function and composition of macrophages in the pathogenesis of MAFLD, which provides a new insight for the treatment of MAFLD.
文章引用：廖凯, 杨连, 龚建平. 肝内巨噬细胞在代谢相关脂肪性肝病中的研究进展[J]. 临床医学进展, 2021, 11(4): 1608-1614. https://doi.org/10.12677/ACM.2021.114231

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