调节性T细胞在肝脏移植免疫耐受中的作用
Role of Regulatory T Cells in Immune Tolerance in Liver Transplantation
DOI: 10.12677/ACM.2021.114234, PDF,    国家自然科学基金支持
作者: 张 剑：重庆市璧山区妇幼保健院外科，重庆；刘 涛, 龚建平*：重庆医科大学附属第二医院肝胆外科，重庆
关键词: 调节性T细胞；肝移植；免疫耐受；Regulatory T Cells； Liver Transplantation； Immune Tolerance
摘要: 肝移植是终末肝病唯一有效的治疗方式，但是肝移植术后建立免疫耐受的问题一直没有得到很好的解决。人的肝脏含有不同的效应性淋巴细胞亚群，它们由调节性T细胞(regulatory t cells, Treg)的细胞亚群来控制。免疫抑制是抗原特异性的，这需要Treg的激活来协调完成。因此，Treg在维持肝移植免疫耐受方面具有至关重要的作用，是诱导肝移植免疫耐受形成的关键细胞。本文将就Treg与肝移植免疫耐受的关系以及相关机制进行简要介绍。
Abstract: Liver transplantation is the only effective treatment for terminal liver disease, but the problem of establishing immune tolerance after liver transplantation has not been well solved. The human liver contains different subsets of effector lymphocytes that are kept in check by a subpopulation as Regulatory T cells (Treg). Treg plays an important role in immune regulation, so the balance between effector and regulatory lymphocytes usually determines the outcome of liver immunity. Therefore, Treg plays a crucial role in maintaining immune tolerance in liver transplantation and is a key cell for inducing the formation of immune tolerance in liver transplantation. This article will briefly introduce the relationship between Treg and immune tolerance in liver transplantation as well as the relevant mechanisms.
文章引用：张剑, 刘涛, 龚建平. 调节性T细胞在肝脏移植免疫耐受中的作用[J]. 临床医学进展, 2021, 11(4): 1630-1635. https://doi.org/10.12677/ACM.2021.114234

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