经鼻腔给药的纳米颗粒及其治疗脑部疾病的进展
Nanoparticles Administered through Nasal Cavity and Its Progress in the Treatment of Brain Diseases
DOI: 10.12677/HJBM.2021.112010, PDF,    科研立项经费支持
作者: 邓爱林*, 柯腾飞, 罗玥媛, 保莎莎, 廖承德#：云南省肿瘤医院/昆明医科大学第三附属医院放射科，云南 昆明
关键词: 鼻腔给药；脑部疾病；脂质纳米颗粒；纳米乳液；壳聚糖纳米颗粒；Nasal Administration； Brain Diseases； Lipid Nanoparticles； Nanoemulsion； Chitosan Nanoparticles
摘要: 血脑屏障是人脑的一种重要功能性屏障，也是药物治疗脑部疾效果欠佳的重要原因。鼻腔给药作为一种非侵入性的脑部给药方式，联合纳米颗粒能有效透过血脑屏障，提高进入脑内的药物浓度，从而改善脑部疾病的治疗效果。本文章将对适用于经鼻腔给药的纳米颗粒，用于治疗脑部疾病的研究进展进行综述。
Abstract: Blood-brain barrier is an important functional barrier of human brain, and it is also an important reason for the poor effect of drug treatment on brain diseases. Nasal administration, as a non-invasive way of brain administration, combined with nanoparticles, can effectively penetrate the blood-brain barrier and increase the concentration of drugs entering the brain, thus improving the therapeutic effect of brain diseases. In this article, we will review the research progress of na-noparticles for intranasal administration in the treatment of brain diseases.
文章引用：邓爱林, 柯腾飞, 罗玥媛, 保莎莎, 廖承德. 经鼻腔给药的纳米颗粒及其治疗脑部疾病的进展[J]. 生物医学, 2021, 11(2): 69-74. https://doi.org/10.12677/HJBM.2021.112010

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