多囊卵巢综合征发病机制探讨
Pathogenesis of Polycystic Ovary Syndrome
DOI: 10.12677/ACM.2021.114244, PDF,   
作者: 朱海静, 李泳诗, 欧湘红*：南华大学教学医院广东省第二人民医院，广东 广州；广东省第二人民医院生殖医学中心生殖力保护实验室，广东 广州；李妍楚, 杜文豪, 杨琳俐：广东省第二人民医院生殖医学中心生殖力保护实验室，广东 广州
关键词: 多囊卵巢综合征；HPO轴功能紊乱；肠道菌群；生物节律；胰岛素抵抗；Polycystic Ovary Syndrome； HPO Axis Dysfunction； Intestinal Flora； Circadian Rhythm； Insulin Resistance
摘要: 多囊卵巢综合征(polycystic ovary syndrome, PCOS)是育龄女性最常见的疾病，整体患病率为10%~19.9%，具有多种短期和长期不良后果，是一种影响全世界数百万妇女的生殖、内分泌和代谢紊乱性疾病。至今该病的发生机制仍不明确，大多数学者认为PCOS为遗传易感基因与环境因素相互作用的结果，对该病的治疗策略及对远期并发症的管理方法仍然有限。本文是对与PCOS发病相关的潜在病因机制的系统综述，通过对发病机制的探索，寻找未来治疗的新靶点、新方向。
Abstract: Polycystic ovary syndrome (PCOS) is the most common disease in women of childbearing age, which overall prevalence rate is 10%~19.9%. It is a pathema that causes a variety of short-term and long-term adverse consequences in reproduction, endocrine and metabolism that affects millions of women all over the world. Nevertheless, the pathogenesis of PCOS is still unclear. Most experts believe that PCOS is the result of the interaction of genetic susceptibility genes and environmental factors. The treatment strategies and management methods of long-term complications of PCOS are still limited. This article is a systematic review of the underlying pathogenesis of PCOS targeting for looking for new targets and new directions of treatment in the future through the exploration of the pathogenesis.
文章引用：朱海静, 李泳诗, 李妍楚, 杜文豪, 杨琳俐, 欧湘红. 多囊卵巢综合征发病机制探讨[J]. 临床医学进展, 2021, 11(4): 1703-1709. https://doi.org/10.12677/ACM.2021.114244

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