Kupffer细胞在原发性肝癌发病机制中的作用
Effect of Kupffer Cells in the Pathogenesis of Primary Liver Cancer
DOI: 10.12677/ACM.2021.114248, PDF,   
作者: 张 剑：重庆市璧山区妇幼保健院，重庆；朱 珠, 龚建平*：重庆医科大学附属第二医院，肝胆外科，重庆
关键词: 原发性肝癌；Kupffer细胞；靶向治疗；综述；Primary Liver Cancer； Kupffer Cells； Targeted Therapy； Review
摘要: 近年来，由于与肿瘤有关的巨噬细胞这一新概念的产生和出现，人们开始越来愈多地关注巨噬细胞在肿瘤的形成及其演变过程中所起到的作用。Kupffer细胞作为一类位于肝脏中的特殊巨噬细胞，是天然免疫系统的组成部分，由血液中的单核细胞黏附在肝窦壁上进行分化形成。在特殊的生理条件下，可以通过吞噬作用来快速清除血循环中的异物颗粒或红细胞；而在病理状态下，则能够促进肝脏内的星状细胞的激活，进而增强和促进肝脏组织的纤维化。此外，作为肝脏免疫细胞中的较重要的组分，Kupffer细胞在肝癌中的作用机制、以及基于Kupffer细胞的靶向治疗一直都受到人们的广泛关注。本文就目前已有的研究，综述了肝癌中Kupffer细胞的作用机制及其靶向治疗。
Abstract: In recent years, with the introduction of the concept of tumor-associated macrophages, the role of macrophages in tumorigenesis and development has been paid more and more attention. As a special kind of macrophages located in the liver, Kupffer cells are an important component of the innate immune system, which are differentiated by blood monocytes adhering to the hepatic sinusoid wall. In physiological environment, foreign body particles or red blood cells in blood circulation can be removed by phagocytosis; in pathological condition, hepatic stellate cells can be activated and liver fibrosis can be promoted. In addition, as an important component of liver immune cells, the mechanism of Kupffer cells in liver cancer and the targeted therapy based on Kupffer cells have been widely concerned. Based on the existing studies, this paper reviews the mechanism of action and targeted therapy of Kupffer cells in hepatocellular carcinoma.
文章引用：张剑, 朱珠, 龚建平. Kupffer细胞在原发性肝癌发病机制中的作用[J]. 临床医学进展, 2021, 11(4): 1726-1732. https://doi.org/10.12677/ACM.2021.114248

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