PG-SGA评分与胃癌患者病理分期的相关性研究

The Correlation Study of PG-SGA and Pathological Stage of Patients with Gastric Cancer

摘要: 目的：研究患者病理分期、血浆白蛋白、年龄、脉管浸润、肿瘤大小、BMI与胃癌患者主观整体评估(PG-SGA)评分的相关性。探讨胃癌患者病理分期对营养不良风险严重程度的影响。方法：采用连续入组法，纳入我院自2019年8月至2020年8月接受外科手术的248例胃癌患者，入院24小时运用PG-SGA对患者进行营养风险状态评估，并测定患者白蛋白(Alb)、身体质量指数(BMI)，并收集患者的病理报告内容。结果：营养不良风险严重程度在患者脉管浸润、病理分期、年龄、白蛋白、肿瘤大小、BMI有统计学意义p < 0.05。在民族、性别上无统计学意义p > 0.05。筛查出来的影响因素，行logistic回归分析研究。1、BMI是胃癌患者营养不良风险严重程度的独立保护因素，BMI越高，营养不良风险程度越低。2、血浆白蛋白是营养不良风险严重程度的独立保护因素，血浆白蛋白越高，营养不良风险程度越低。3、年龄越高出现的营养不良风险严重程度越高。4、病理分期是营养不良风险程度的独立影响因素，病理分期越高出现的营养不良风险严重程度越高。5、脉管浸润、肿瘤大小不是营养不良风险严重程度的独立影响因素p > 0.05。结论：1、血浆白蛋白、BMI是营养不良风险严重程度的独立保护因素。2、年龄是胃癌患者营养不良风险严重程度的独立危险因素。3、胃癌患者的病理分期越高，患者的营养不良风险越严重，病理分期是营养不良风险严重程度的独立危险因素。

Abstract: Objective: To study the correlation between patients’ pathological stage, plasma albumin (Alb), (body mass index) BMI, age, tumor size, vascular infiltration and PG-SGA score of gastric cancer patients; To explore the influence of pathological staging on the severity of malnutrition risk. Methods: 248 patients with gastric cancer who underwent surgical operations in our hospital from August 2019 to August 2020 were enrolled using consecutive sampling in this study. After 24 hours of admission, PG-SGA were used to evaluate the nutritional status of the patient, and to measure the Alb, BMI and collect the content of the patient’s pathology report. Results: The severity of malnutrition risk is statistically significant in patients with vascular infiltration, pathological stage, age, albumin, tumor size, and BMI (p < 0.05). There was no statistically significant in terms of ethnicity, gender (p > 0.05). Based on the influencing factors identified by the above single factor screening, multi-factor logistic analysis was performed. 1. BMI is an independent protective factor for the severity of malnutrition risk in patients with gastric cancer, meaning that the higher the BMI, the lower the risk of malnutrition. 2. Plasma albumin is an independent protective factor for the severity of malnutrition risk. The higher the plasma albumin, the lower the risk of malnutrition. 3. The higher the age, the higher the severity of the risk of malnutrition. 4. Pathological staging is an independent factor influencing the degree of malnutrition risk. The higher the pathological stage, the higher the severity of the risk of malnutrition, which means that the pathological stage is an independent risk factor for the severity of the risk of malnutrition. 5. Vascular infiltration, tumor size are not the independent factors influencing the severity of malnutrition risk (p > 0.05). Conclusion: 1. Alb and BMI are independent protective factors for the severity of malnutrition risk. 2. Age is an independent risk factor for the severity of malnutrition risk. 3. The higher the pathological stage of gastric cancer patients, the more serious the risk of malnutrition.