秋水仙碱致急性肾损伤1例并文献复习
A Case of Acute Kidney Injury Caused by Colchicine Poisoning and Literature Review
DOI: 10.12677/ACM.2021.114276, PDF,   
作者: 刘莹莹：青岛大学医学部，山东 青岛；刘雪梅*：青岛大学附属医院肾病科，山东 青岛
关键词: 秋水仙碱中毒；急性肾损伤；治疗；Colchicine Poisoning； Acute Kidney Injury； Therapy
摘要: 目的：提高临床医师对秋水仙碱中毒导致急性肾损伤的发生机制、临床表现及治疗措施的认识。方法：我们对青岛大学附属医院收治的1例秋水仙碱中毒致急性肾损伤患者的临床资料进行回顾性分析，并且复习相关文献。结果：给予连续肾脏替代疗法(Continuous Renal Replacement Therapy, CRRT)、血浆置换、成分输血、刺激骨髓造血、抗感染、纠正电解质紊乱、营养心肌等一系列对症支持治疗后好转出院。结论：秋水仙碱大剂量服用可出现严重急性肾损伤，早期进行积极对症处理，可提高患者存活率和减少并发症的发生。
Abstract: Objective: To improve the understanding of the pathogenesis, clinical manifestation and treatment of acute kidney injury caused by colchicine poisoning. Methods: We retrospectively analyzed the clinical data of a patient with acute kidney injury caused by colchicine poisoning in the Affiliated Hospital of Qingdao University, and reviewed relevant literature. Results: The patient was given a series of symptomatic supportive treatments, such as plasma exchange, continuous renal replacement therapy, component transfusion, anti-infective therapy, and myocardial nutrition, and then she was improved and discharged. Conclusion: Large-dose colchicine can cause severe acute kidney injury. Early symptomatic treatment can improve the survival rate of patients and reduce the incidence of complications.
文章引用：刘莹莹, 刘雪梅. 秋水仙碱致急性肾损伤1例并文献复习[J]. 临床医学进展, 2021, 11(4): 1920-1924. https://doi.org/10.12677/ACM.2021.114276

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