慢性心力衰竭患者CA125水平与心功能及心室重构的相关性

Correlation of Serum CA125 Levels with Cardiac Function and Ventricular Remodeling in Patients with Chronic Heart Failure

摘要: 目的：探究慢性心力衰竭患者血清CA125水平与心功能及心室重构的相关性。方法：入选2019年6月至2019年12月心力衰竭住院患者80例，按纽约心功能分级标准分为心功能I级15例，II级23例，III级24例，IV级18例。同时收集同期入院的体检人员60例作为对照组。采用电化学发光法测定血清CA125水平，测量左室舒张末期内径(left ventricular end-diastolic diameter, LVEDD)、左室后壁厚度(left ventricular posterior wall thickness, LVPWT)及室间隔厚度(ventricular septal thickness, IVST)、左心室质量(left ventricular mass, LVM)、左心室质量指数(left ventricular mass index, LVMI)等心功能相关指标。分析血清CA125水平与心功能及心室重构的相关性。结果：心力衰竭患者CA125水平明显高于对照组，其水平与心功能的严重程度成正比，LVEDD、LVPWT 、IVST等指标也随着心功能的加重而增加。CA125与这些指标具有正相关性(r = 0.23, 0.268, 0.284, 0.365, 0.450; P < 0.05)。结论：心衰患者CA125水平越高心功能越低，其水平与心脏左心室重构呈正相关，可作为评价CHF患者心功能的一个重要指标。

Abstract: Objective: To investigate the correlation between serum CA125 level and cardiac function and ventricular remodeling in patients with chronic heart failure. Methods: In June 2019 to December 2019, 80 cases of hospitalized patients with heart failure, heart function according to the New York heart function classification standard are divided into Class I 15 cases, II 23 cases, III level 24 cases, IV 18 cases. At the same time, 60 cases of physical examination personnel hospitalized during the same period were collected as the control group. The serum CA125 level was determined by electrochemiluminescence method, and the cardiac function related indexes such as left ventricular end-diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPWT) and interventricular septal thickness (IVST), left ventricular mass (LVM) and left ventricular mass index (LVMI) were measured. The correlation between serum CA125 level and cardiac function and ventricular remodeling was analyzed. Results: The level of CA125 in patients with heart failure was significantly higher than that in the control group. The level of CA125 was directly proportional to the severity of heart function. The indexes of LVEDD, LVPWT and IVST also increased with the aggravation of heart function. CA125 was positively correlated with these indexes (r = 0.23, 0.268, 0.284, 0.365, 0.450; P < 0.05). Conclusion: The higher CA125 level in patients with heart failure, the lower cardiac function. CA125 level is positively correlated with left ventricular remodeling, which can be used as an important index to evaluate cardiac function in patients with CHF.