中药黄酮抗氧化作用及其在化妆品中的应用研究
Study on Antioxidant Effect of Chinese Traditional Medicine Flavonoids and Its Application in Cosmetics
摘要: 皮肤氧化与年龄增长生理代谢功能变弱、氧化应激、外界环境的刺激(如紫外线辐照等)密切相关。中药黄酮具有抗氧化、抗衰老、抗菌和抗炎等广泛的药理活性，在新型化妆品研发中具有一定的潜在优势。本文结合皮肤老化机制，概述了中药黄酮抗氧化机制，发现中药黄酮能够清除自由基，阻断自由基反应，提高超氧化歧化酶(Superoxide-Dismutase, SOD)、谷胱甘肽过氧化物酶(Glutathione peroxidase, GSH-Px)、过氧化氢酶(Catalase from micrococcus, CAT)等抗氧化酶和金属硫蛋白等抗氧化蛋白活性，调节关键因子Nrf2和激活丝氨酸激酶(phos-phoinositide 3-kinase, PI3K)信号传导通路、AMP依赖的蛋白激酶(Adenosine 5’-monophosphate AMP-activated protein kinase, AMPK)信号传导通路和抑制丝裂原活化蛋白激酶(mitogen-activated protein kinases, MAPK)等信号通路，缓解氧化应激状态，起到抗氧化的作用。进一步地，综述了中药黄酮在抗氧化面膜、乳霜和防晒剂等护肤品的应用及相关产品开发，比较此类产品的抗氧化机制与效果。
Abstract: Skin oxidation is closely related to the decreasing of physiological and metabolic function of aging, oxidative stress and external environmental stimulation (such as ultraviolet radiation). Flavonoids of traditional Chinese medicine has a wide range of pharmacological activities, such as anti-oxidation, anti-aging, anti-bacterial and anti-inflammatory, and has certain potential advantages in cosmetics. Based on the mechanism of skin aging, the flavonoids of traditional Chinese medicine shows efficient antioxidant activity, by eliminating free radicals to blocked the chain reaction of free radicals, improving the activity of antioxidant enzymes and metal sulfur proteins, including Superoxide-Dismutase (SOD), Glutathione peroxidase (GSH-Px), Catalase from micrococcus (CAT), etc., adjusting the key factor Nrf2, the phosphoinositide 3-kinase(PI3K) signaling pathways, Adenosine 5’-monophosphate activated protein kinase (AMPK) signaling pathways, inhibiting the mitogen-activated protein kinases (MAPK) signaling pathways and relieving the oxidative stress. Furthermore, the application of Chinese traditional medicine flavonoids in anti-oxidation facial mask, cream, sunscreen and other skin care products and the development of related products were reviewed, and the anti-oxidation mechanism and effect of these products were compared.
文章引用：张瑜芯, 赵梦佳, 尹梓在, 姚熙霖, 金丽霞, 宋腾蛟. 中药黄酮抗氧化作用及其在化妆品中的应用研究[J]. 药物资讯, 2021, 10(3): 78-84. https://doi.org/10.12677/PI.2021.103011

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