新生儿败血症抗生素治疗的研究进展
Research Advances in Antibiotic Treatment of Neonatal Sepsis
DOI: 10.12677/ACM.2021.115300, PDF,   
作者: 王 芳, 韦 红:重庆医科大学附属儿童医院新生儿科,重庆;儿童发育疾病研究教育部重点实验室,重庆;国家儿童健康与疾病临床医学研究中心,重庆;儿童发育重大疾病国家国际科技合作基地,重庆;儿科学重庆市重点实验室,重庆
关键词: 新生儿败血症抗生素研究进展Neonatal Sepsis Antibiotics Research Progress
摘要: 新生儿败血症是新生儿期严重的感染性疾病,是严重威胁新生儿生命的常见疾病之一,发病率及死亡率均较高,早期合理的有效的抗生素治疗是控制感染、降低死亡率、减少并发症的关键,但抗生素的滥用会增加耐药菌产生的风险,合理有效的抗生素管理是必不可少的,本文对目前新生儿败血症的抗生素选择进行了总结。
Abstract: Neonatal sepsis is a serious infectious disease in the neonatal period and is one of the common reason that seriously threaten the lives of newborns, with high morbidity and mortality. Early and reasonable effective antibiotic treatment is the key to controlling infection, reducing mortality and minimizing complications, but the misuse of antibiotics increases the risk of drug-resistant bacteria occurrence, reasonable and effective antibiotic management is essential. This article summarises the current antibiotic choices for sepsis.
文章引用:王芳, 韦红. 新生儿败血症抗生素治疗的研究进展[J]. 临床医学进展, 2021, 11(5): 2094-2099. https://doi.org/10.12677/ACM.2021.115300

参考文献

[1] 李志强, 王冠达, 黄艳. 延时与间断输注美罗培南治疗重症感染患者的系统评价[J]. 中国医院药学杂志, 2017, 37(2): 155-160.
[2] Rhodes, A., Evans, L.E., Alhazzani, W., Levy, M.M., Antonelli, M., Ferrer, R., et al. (2017) Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med, 43, 304-377. [Google Scholar] [CrossRef] [PubMed]
[3] Ain Ibrahim, N., Makmor Bakry, M., Mohd Tahir, N.A., Mohd Zaini, N.R. and Mohamed Shah, N. (2020) A Prospective Cohort Study of Factors Associated with Empiric Antibiotic De-Escalation in Neonates Suspected with Early Onset Sepsis (EOS). Pediatric Drugs, 22, 321-330. [Google Scholar] [CrossRef] [PubMed]
[4] 闫桦, 王晶, 齐赛卿, 张海峰. 美罗培南在新生儿重症感染治疗中的应用价值及安全性[J]. 儿科药学杂志, 2017, 23(2): 16-18.
[5] Luque-Sastre, L., Arroyo, C., Fox, E.M., McMahon, B.J., Bai, L., Li, F. and Fanning, S. (2018) Antimicrobial Resistance in Listeria Species. In: Schwarz, S., Cavaco, L. and Shen, J., Eds., Antimicrobial Resistance in Bacteria from Livestock and Companion Animals, ASM Press, Washington DC, 237-259. [Google Scholar] [CrossRef
[6] Schechner, V., Temkin, E., Harbarth, S., Carmeli, Y. and Schwaber, M.J. (2013) Epidemiological Interpretation of Studies Examining the Effect of Antibiotic Usage on Resistance. Clinical Microbiology Reviews, 26, 289-307. [Google Scholar] [CrossRef
[7] Liu, L., Oza, S., Hogan, D., Chu, Y., Perin, J., Zhu, J., Lawn, J.E., Cousens, S., Mathers, C. and Black, R.E. (2016) Global, Regional, and National Causes of Under-5 Mortality in 2000-15: An Updated Systematic Analysis with Implications for the Sustainable Development Goals. The Lancet, 388, 3027-3035. [Google Scholar] [CrossRef
[8] Polin, R.A. and the Committee on Fetus and Newborn (2012) Management of Neonates with Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics, 129, 1006-1015. [Google Scholar] [CrossRef] [PubMed]
[9] Dong, Y. and Speer, C.P. (2015) Late-Onset Neonatal Sepsis: Recent Developments. Archives of Disease in Childhood-Fetal and Neonatal Edition, 100, F257-F263. [Google Scholar] [CrossRef] [PubMed]
[10] Fjalstad, J.W., Stensvold, H.J., Bergseng, H., Simonsen, G.S., Salvesen, B., Ronnestad, A.E. and Klingenberg, C. (2016) Early-Onset Sepsis and Antibiotic Exposure in Term Infants: A Nationwide Population-Based Study in Norway. The Pediatric Infectious Disease Journal, 35, 1-6. [Google Scholar] [CrossRef
[11] Hamer, D.H., Darmstadt, G.L., Carlin, J.B., Zaidi, A.K., Yeboah-Antwi, K., Saha, S.K., et al. (2015) Etiology of Bacteremia in Young Infants in Six Countries. The Pediatric Infectious Disease Journal, 34, e1-e8. [Google Scholar] [CrossRef
[12] Lee, J.H., Hornik, C.P, Benjamin Jr., D.K., Herring, A.H., Clark, R.H., Cohen-Wolkowiez, M. and Smith, P.B. (2013) Risk Factors for Invasive Candidiasis in Infants >1500g Birth Weight. The Pediatric Infectious Disease Journal, 32, 222-226. [Google Scholar] [CrossRef
[13] Kuppala, V.S., Meinzen-Derr, J., Morrow, A.L. and Schibler, K.R. (2011) Prolonged Initial Empirical Antibiotic Treatment Is Associated with Adverse Outcomes in Premature Infants. The Journal of Pediatrics, 159, 720-725. [Google Scholar] [CrossRef] [PubMed]
[14] Oosterloo, B.C., van Elburg, R.M., Rutten, N.B., Bunkers, C.M., Crijns, C.E., Meijssen, C.B., Oudshoorn, J.H., Rijkers, G.T., van der Ent, C.K. and Vlieger, A.M. (2018) Wheezing and Infantile Colic Are Associated with Neonatal Antibiotic Treatment. Pediatric Allergy and Immunology, 29, 151-158. [Google Scholar] [CrossRef] [PubMed]
[15] Cotten, C.M., Taylor, S., Stoll, B., Goldberg, R.N., Hansen, N.I., Sanchez, P.J., Ambalavanan, N., Benjamin, D.K., Jr. and Network, N.N.R. (2009) Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated with Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants. Pediatrics, 123, 58-66. [Google Scholar] [CrossRef] [PubMed]
[16] Folgori, L., Ellis, S.J., Bielicki, J.A., Heath, P.T., Sharland, M. and Balasegaram, M. (2017) Tackling Antimicrobial Resistance in Neonatal Sepsis. The Lancet Global Health, 5, e1066-e1068. [Google Scholar] [CrossRef
[17] Leroux, S., Zhao, W., Betremieux, P., Pladys, P., Saliba, E. and Jacqz-Aigrain, E. on Behalf of the French Society of Neonatology (2015) Therapeutic Guidelines for Prescribing Antibiotics in Neonates Should Be Evidence-Based: A French National Survey. Archives of Disease in Childhood, 100, 394-398. [Google Scholar] [CrossRef] [PubMed]
[18] Caffrey Osvald, E. and Prentice, P. (2014) NICE Clinical Guideline: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection. Archives of Disease in Childhood-Education and Practice, 99, 98-100. [Google Scholar] [CrossRef] [PubMed]
[19] Cantey, J.B. (2016) Optimizing the Use of Antibacterial Agents in the Neonatal Period. Pediatric Drugs, 18, 109-122. [Google Scholar] [CrossRef] [PubMed]
[20] Stoll, B.J., Hansen, N.I., Adams-Chapman, I., Fanaroff, A.A., Hintz, S.R., Vohr, B. and Higgins, R.D. (2004) Neurodevelopmental and Growth Impairment among Extremely Low-Birth-Weight Infants with Neonatal Infection. JAMA, 292, 2357-2365. [Google Scholar] [CrossRef] [PubMed]
[21] 中华医学会儿科学分会新生儿学组, 中国医师协会新生儿科医师分会感染专业委员会. 新生儿败血症诊断及治疗专家共识(2019年版) [J]. 中华儿科杂志, 2019, 57(4): 252-257.
[22] Sivanandan, S., Soraisham, A.S. and Swarnam, K. (2011) Choice and Duration of Antimicrobial Therapy for Neonatal Sepsis and Meningitis. International Journal of Pediatrics, 2011, Article ID: 712150. [Google Scholar] [CrossRef] [PubMed]
[23] Kempley, S., Kapellou, O., McWilliams, A., Banerjee, J., McCorqodale, A. and Millar, M. (2015) Antibiotic Treatment Duration and Prevention of Complications in Neonatal Staphylococcus aureus Bacteraemia. Journal of Hospital Infection, 91, 129-135. [Google Scholar] [CrossRef] [PubMed]
[24] Murphy, K. and Weiner, J. (2012) Use of Leukocyte Counts in Evaluation of Early-Onset Neonatal Sepsis. The Pediatric Infectious Disease Journal, 31, 16-19. [Google Scholar] [CrossRef
[25] Stocker, M., van Herk, W., el Helou, S., Dutta, S., Fontana, M.S., Schuerman, F.A.B.A., van den Tooren-de Groot, R.K., Wieringa, J.W., Janota, J., van der Meer-Kappelle, L.H., et al. (2017) Procalcitonin-Guided Decision Making for Duration of Antibiotic Therapy in Neonates with Suspected Early-Onset Sepsis: A Multicentre, Randomised Controlled Trial (NeoPIns). The Lancet, 390, 871-881. [Google Scholar] [CrossRef
[26] Berardi, A., Tzialla, C., Travan, L., Bua, J., Santori, D., Azzalli, M., Spada, C. and Lucaccioni, L. on Behalf of the GBS Prevention Working Group of Emilia-Romagna (2018) Secondary Prevention of Early-Onset Sepsis: A Less Invasive Italian Approach for Managing Neonates at Risk. Italian Journal of Pediatrics, 44, Article No. 73. [Google Scholar] [CrossRef] [PubMed]
[27] Benitz, W.E., Wynn, J.L. and Polin, R.A. (2015) Reappraisal of Guidelines for Management of Neonates with Suspected Early-Onset Sepsis. Journal of Pediatrics, 166, 1070-1074. [Google Scholar] [CrossRef] [PubMed]