海洋来源曲霉属真菌天然产物及其生物活性研究现状
Current Research on Natural Products and Biological Activities of Aspergillus Fungi from Marine Sources
摘要: 海洋覆盖了地球表面70%以上的区域，与陆地相比，呈现出许多不同的特定恶劣环境条件。具体而言，海洋包含温度，静水压力和盐度水平范围广等的特征。响应海洋环境，海洋微生物如真菌逐渐进化出许多特殊的适应机制，包括产生特定的次生代谢产物作为生物分子。海洋生态系统中存在的巨大生物多样性为寻找具有众多有价值生物活动的新化合物提供了有希望的资源。因此，对海洋真菌尤其是曲霉属中次生代谢产物的探索研究为先导药物的开发提供了重要的资源。本文对近年来从海洋来源曲霉属真菌中获得的天然产物以结构的不同进行了列举，并指出了其生物活性，暗示着曲霉属真菌在海洋微生物高效活性乃至药用价值的天然产物的挖掘工作中值得重视。
Abstract: The ocean covers more than 70% of the Earth’s surfaces exhibiting have many different specific harsh environmental conditions compared to land. Specifically, oceans contain characterized by a wide range of temperatures, hydrostatic pressure and levels of salinity. In response to the marine environment, microorganisms have gradually evolved many special different adaptation mechanisms, including the production of specific secondary metabolites as biomolecules. The enormous biodiversity present in marine ecosystems provides a promising resource to find new compounds with numerous worthwhile biological activities. Therefore, the exploration of marine fungi, especially the secondary metabolites of Aspergillus, has formed a powerful driving force for drug discovery. This article enumerates the natural products obtained from marine-sourced Aspergillus fungi in recent years in terms of structural differences, and points out their biological activities, implying that Aspergillus fungi may play an important role in the excavation of natural products with high-efficiency activity and medicinal value from marine microorganisms.
文章引用：李欢欢, 杜新阳, 陈超逸, 祁江峰, 王颖. 海洋来源曲霉属真菌天然产物及其生物活性研究现状[J]. 药物资讯, 2021, 10(3): 92-101. https://doi.org/10.12677/PI.2021.103013

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