海洋曲霉属真菌天然产物及基因组挖掘技术的应用
The Natural Products of Marine-Derived Aspergillus Fungi and Application of Genome Mining
摘要: 海洋环境具有高压、高盐、低营养、低光照、低氧的特征，因此相比于陆地来源的相同种属的真菌，海洋来源真菌具有更大的产生新型天然产物的能力。到目前为止，已经从海洋来源真菌当中分离得到了上万种化合物。曲霉属真菌作为目前研究最为深入的一个种属，深受研究人员的关注和重视。基因组挖掘技术的发展打破了传统化学分离手段的限制，为寻找新型天然产物提供了新的方法，已经被应用于海洋天然产物的发现当中。本篇文章对海洋来源曲霉属真菌天然产物进行了总结，并对基因组挖掘技术在海洋真菌天然产物发现中的应用进行了初步概括。基因组挖掘技术已经被应用于海洋真菌天然产物的开发当中，是海洋真菌及其天然产物开发的常用手段，加快了先导化合物和生物资源的研究效率。
Abstract: The marine environment has the characteristics of high pressure, high salt, low nutrition, low light, and low oxygen. Therefore, compared with fungi of the same species from terrestrial sources, marine-derived fungi have a greater ability to produce new natural products. So far, tens of compounds have been isolated from marine-derived fungi. As the most researched species, Aspergillus has received much attention and researchers. The development of genome mining technology has broken the limitations of traditional chemical separation methods and provided a new method for finding new natural products. It has been applied to the discovery of marine natural products. This article summarizes the natural products of marine-derived Aspergillus fungi, and preliminarily summarizes the application of genome mining technology in the discovery of marine fungal natural products. Genome mining technology has been applied to the development of natural products of marine fungi. It is a common method for the development of marine fungi and their natural products, speeding up the research efficiency of lead compounds and biological resources.
文章引用：杜新阳, 李欢欢, 祁江峰, 陈超逸, 王颖. 海洋曲霉属真菌天然产物及基因组挖掘技术的应用[J]. 药物资讯, 2021, 10(3): 102-111. https://doi.org/10.12677/PI.2021.103014

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