种植导向的血管化腓骨肌皮瓣移植在颌面部骨缺损重建修复中的临床应用
Clinical Application of Vascularized Fibula Free Flap Transplantation Combined with Implantation in Reconstruction and Repair of Maxillofacial Bone Defect
DOI: 10.12677/ACM.2021.115317, PDF,   
作者: 孙一航*, 刘雁鸣#:浙江大学医学院附属第二医院口腔颌面外科,浙江 杭州
关键词: 骨缺损牙列缺损血管化腓骨瓣移植种植修复数字化外科Bone Defect Dentition Defect Vascularized Fibula Free Flap Implant Digital Surgery
摘要: 外伤、肿瘤、手术等一系列的原因,可能会导致患者出现颌面部的骨缺损,往往伴随大面积的牙列缺损,相对应的咀嚼及发音功能也受到较大影响。而随着种植外科的不断发展,关注点也不再只局限于颜面外形上的恢复,更多转移至口腔功能上的重建修复。为了同时覆盖这两种需求,目前临床上应用较多的方式主要是通过游离骨组织瓣(包括腓骨肌皮瓣、髂骨肌皮瓣、肩胛骨肌皮瓣等)来修复相应大面积软硬组织复合缺损,而后修复牙列缺损。本文主要讨论其中的游离血管化腓骨肌皮瓣移植结合日益成熟的种植外科技术,修复伴牙列缺损的颌面部骨组织缺损,以达到最大程度恢复患者术后美观及功能需求的相关临床进展。
Abstract: A series of reasons such as trauma, tumor, surgery, etc. may cause the patient to have maxillofacial bone defect, which is often accompanied by large area of dentition defect, and the corresponding chewing and pronunciation functions are also greatly affected. With the continuous development of implant surgery, the focus is no longer limited to the restoration of facial appearance, but more to the reconstruction and restoration of oral function. In order to cover these two needs at the same time, the current clinical application is mainly to use free bone tissue flaps (including fibula free flap, iliac crest free flap, scapula free flap, etc.) to repair the complex maxillofacial defect, and then the dentition defect. This article mainly discusses the related clinical progress of vascularized fibula free flap transplantation combined with increasingly mature implant surgery techniques to repair maxillofacial bone tissue defects and dentition defects in order to maximize the recovery of postoperative aesthetic and functional needs of patients.
文章引用:孙一航, 刘雁鸣. 种植导向的血管化腓骨肌皮瓣移植在颌面部骨缺损重建修复中的临床应用[J]. 临床医学进展, 2021, 11(5): 2204-2213. https://doi.org/10.12677/ACM.2021.115317

参考文献

[1] 胡永杰, 曲行舟, 郑家伟, 等. 游离组织瓣在口腔颌面-头颈肿瘤缺损修复中的应用: 2549例临床分析[J]. 中国口腔颌面外科杂志, 2007, 5(5): 335-359.
[2] 张陈平, 张志愿, 邱蔚六, 等. 口腔颌面部缺损的修复重建——1973例临床分析[J]. 中国修复重建外科杂志, 2005, 19(10): 773-776.
[3] Wilkman, T., Apajalahti, S., Wilkman, E., et al. (2017) A Comparison of Bone Resorption over Time: An Analysis of the Free Scapular, Iliac Crest, and Fibular Microvascular Flaps in Mandibular Reconstruction. Journal of Oral and Maxillofacial Surgery, 75, 616-621. [Google Scholar] [CrossRef] [PubMed]
[4] 张志愿, 等. 口腔颌面外科学[M]. 第7版. 北京: 人民卫生出版社, 2015.
[5] 竺涵光, 张陈平, 孙坚, 等. 腓骨肌皮瓣重建下颌骨的方法和经验[J]. 口腔颌面外科杂志, 2003(2): 158-161.
[6] 王卫红, 刘宗良, 邹智荣, 等. 腓骨瓣的解剖学研究[J]. 国际口腔医学杂志, 2011, 38(5): 509-510+14.
[7] Bodard, A.G., Salino, S., Desoutter, A., et al. (2015) Assessment of Functional Improvement with Implant-Supported Prosthetic Rehabilitation after Mandibular Reconstruction with a Microvascular Free Fibula Flap: A Study of 25 Patients. Journal of Prosthetic Dentistry, 113, 140-145. [Google Scholar] [CrossRef] [PubMed]
[8] Al Deek, N.F., Kao, H.K. and Wei, F.C. (2018) The Fibula Osteoseptocutaneous Flap: Concise Review, Goal-Oriented Surgical Technique, and Tips and Tricks. Plastic and Reconstructive Surgery, 142, 913e-923e. [Google Scholar] [CrossRef
[9] Ide, Y., Matsunaga, S., Harris, J., et al. (2015) Anatomical Examination of the Fibula: Digital Imaging Study for Osseointegrated Implant Installation. Journal of Otolaryngology—Head & Neck Surgery, 44, Article No. 1. [Google Scholar] [CrossRef] [PubMed]
[10] Brown, J.S., Lowe, D., Kanatas, A., et al. (2017) Mandibular Reconstruction with Vascularised Bone Flaps: A Systematic Review over 25 Years. British Journal of Oral and Maxillofacial Surgery, 55, 113-126. [Google Scholar] [CrossRef] [PubMed]
[11] Patel, S.Y., Kim, D.D. and Ghali, G.E. (2019) Maxillofacial Reconstruction Using Vascularized Fibula Free Flaps and Endosseous Implants. Oral and Maxillofacial Surgery Clinics of North America, 31, 259-284. [Google Scholar] [CrossRef] [PubMed]
[12] Ch’ng, S., Skoracki, R.J., Selber, J.C., et al. (2016) Osseointegrated Implant-Based Dental Rehabilitation in Head and Neck Reconstruction Patients. Head Neck, 38, E321-E327. [Google Scholar] [CrossRef] [PubMed]
[13] Kniha, K., Mohlhenrich, S.C., Foldenauer, A.C., et al. (2017) Evaluation of Bone Resorption in Fibula and Deep Circumflex Iliac Artery Flaps Following Dental Implantation: A Three-Year Follow-Up Study. Journal of Cranio-Maxil- lofacial Surgery, 45, 474-478. [Google Scholar] [CrossRef] [PubMed]
[14] Cebrian-Carretero, J.L., Guinales-Diaz, D.E., Cevallos, J., Sobrino, J.A., et al. (2014) Predictable Dental Rehabilitation in Maxillomandibular Reconstruction with Free Flaps. The Role of Implant Guided Surgery. Medicina Oral, Patologia Oral, Cirugia Bucal, 19, e605-e611. [Google Scholar] [CrossRef] [PubMed]
[15] Rana, M., Chin, S.J., Muecke, T., et al. (2017) Increasing the Accuracy of Mandibular Reconstruction with Free Fibula Flaps Using Functionalized Selective Laser-Melted Patient-Specific Implants: A Retrospective Multicenter Analysis. Journal of Cranio-Maxillofacial Surgery, 45, 1212-1219. [Google Scholar] [CrossRef] [PubMed]
[16] Schepers, R.H., Raghoebar, G.M., Vissink, A., et al. (2015) Accuracy of Fibula Reconstruction Using Patient-Specific CAD/CAM Reconstruction Plates and Dental Implants: A New Modality for Functional Reconstruction of Mandibular Defects. Journal of Cranio-Maxillofacial Surgery, 43, 649-657. [Google Scholar] [CrossRef] [PubMed]
[17] Chuka, R., Abdullah, W., Rieger, J., et al. (2017) Implant Utilization and Time to Prosthetic Rehabilitation in Conventional and Advanced Fibular Free Flap Reconstruction of the Maxilla and Mandible. The International Journal of Prosthodontics, 30, 289-294. [Google Scholar] [CrossRef] [PubMed]
[18] 余丹, 黄建瑶, 于长洋, 等. 咬合引导下改良性颌骨功能重建的临床应用及精度分析[J]. 中国修复重建外科杂志, 2020, 34(11): 1410-1416.
[19] 克热木·阿巴司, 王成刚, 尹小朋, 等. 数字化设计联合3D打印技术在下颌骨成釉细胞瘤术后骨缺损修复的应用[J]. 临床口腔医学杂志, 2020, 36(4): 211-214.
[20] Cabbar, F., Durmus, F.N., Sacak, B., et al. (2018) Implant Stability Outcomes after Immediate and Delayed Revascularized Free Fibula Flaps: A Preliminary Comparative Study. The International Journal of Oral & Maxillofacial Implants, 33, 1368-1373. [Google Scholar] [CrossRef] [PubMed]
[21] Menapace, D.C., Van Abel, K.M., Jackson, R.S., et al. (2018) Primary vs Secondary Endosseous Implantation after Fibular Free Tissue Reconstruction of the Mandible for Osteoradionecrosis. JAMA Facial Plastic Surgery, 20, 401-408. [Google Scholar] [CrossRef] [PubMed]
[22] 李明, 邱憬, 邢树忠, 等. 折叠腓骨肌皮瓣同期牙种植修复下颌骨缺损: 即刻种植延期修复的临床应用[J]. 南京医科大学学报(自然科学版), 2015, 35(9): 1287-1290.
[23] Sandoval, M.L., Rosen, E.B., Robert, A.J., et al. (2020) Immediate Dental Implants in Fibula Free Flaps to Reconstruct the Mandible: A Pilot Study of the Short-Term Effects on Radiotherapy for Patients with Head and Neck Cancer. Clinical Implant Dentistry and Related Research, 22, 91-95. [Google Scholar] [CrossRef] [PubMed]
[24] Jackson, R.S., Price, D.L., Arce, K., et al. (2016) Evaluation of Clinical Outcomes of Osseointegrated Dental Implantation of Fibula Free Flaps for Mandibular Reconstruction. JAMA Facial Plastic Surgery, 18, 201-206. [Google Scholar] [CrossRef] [PubMed]
[25] Koch, F.P., Gotze, E., Kumar, V.V., et al. (2015) A Bar-Retained Overdenture as an External Fixator Device in a Three-Dimensional CAD/CAM-Based Surgical Reconstruction of the Mandible. Journal of Cranio-Maxillofacial Surgery, 43, 1447-1451. [Google Scholar] [CrossRef] [PubMed]
[26] Smith Nobrega, A., Santiago, J.F., De Faria Almeida, D.A., et al. (2016) Irradiated Patients and Survival Rate of Dental Implants: A Systematic Review and Meta-Analysis. Journal of Prosthetic Dentistry, 116, 858-866. [Google Scholar] [CrossRef] [PubMed]
[27] Pauchet, D., Pigot, J.L., Chabolle, F., et al. (2018) Prefabricated Fibula Free Flap with Dental Implants for Mandibular Reconstruction. European Annals of Oto-Rhino-Laryngology, Head and Neck Diseases, 135, 279-282. [Google Scholar] [CrossRef] [PubMed]
[28] Rohner, D., Bucher, P. and Hammer, B. (2013) Prefabricated Fibular Flaps for Reconstruction of Defects of the Maxillofacial Skeleton: Planning, Technique, and Long-Term Experience. The International Journal of Oral & Maxillofacial Implants, 28, e221-e229. [Google Scholar] [CrossRef] [PubMed]
[29] Freudlsperger, C., Bodem, J.P., Engel, E., et al. (2014) Mandibular Reconstruction with a Prefabricated Free Vascularized Fibula and Implant-Supported Prosthesis Based on Fully Three-Dimensional Virtual Planning. Journal of Craniofacial Surgery, 25, 980-982. [Google Scholar] [CrossRef
[30] Pompa, G., Saccucci, M., DI Carlo, G., et al. (2015) Survival of Dental Implants in Patients with Oral Cancer Treated by Surgery and Radiotherapy: A Retrospective Study. BMC Oral Health, 15, 5. [Google Scholar] [CrossRef] [PubMed]
[31] Sammartino, G., Marenzi, G., Cioffi, I., et al. (2011) Implant Therapy in Irradiated Patients. Journal of Craniofacial Surgery, 22, 443-445. [Google Scholar] [CrossRef
[32] Korfage, A., Raghoebar, G.M., Slater, J.J., et al. (2014) Overdentures on Primary Mandibular Implants in Patients with Oral Cancer: A Follow-Up Study over 14 Years. British Journal of Oral and Maxillofacial Surgery, 52, 798-805. [Google Scholar] [CrossRef] [PubMed]
[33] Levine, J.P., Bae, J.S., Soares, M., et al. (2013) Jaw in a Day: Total Maxillofacial Reconstruction Using Digital Technology. Plastic and Reconstructive Surgery, 131, 1386-1391. [Google Scholar] [CrossRef
[34] Carbiner, R., Jerjes, W., Shakib, K., et al. (2012) Analysis of the Compatibility of Dental Implant Systems in Fibula Free Flap Reconstruction. Head & Neck Oncology, 4, 37. [Google Scholar] [CrossRef] [PubMed]
[35] Brauner, E., DI Carlo, S., Ciolfi, A., et al. (2019) Use of Porous Implants for the Prosthetic Rehabilitation of Fibula Free Flap Reconstructed Patients. Journal of Craniofacial Surgery, 30, 1163-1169. [Google Scholar] [CrossRef
[36] Brauner, E., Guarino, G., Jamshir, S., et al. (2015) Evaluation of Highly Porous Dental Implants in Postablative Oral and Maxillofacial Cancer Patients: A Prospective Pilot Clinical Case Series Report. Implant Dentistry, 24, 631-637. [Google Scholar] [CrossRef
[37] Kumar, V.V., Ebenezer, S., Kammerer, P.W., et al. (2016) Implants in Free Fibula Flap Supporting Dental Rehabilitation—Implant and Peri-Implant Related Outcomes of a Randomized Clinical Trial. Journal of Cranio-Maxillofacial Surgery, 44, 1849-1858. [Google Scholar] [CrossRef] [PubMed]
[38] Maluf, P.S., Ching, A.W., Angeletti, P., et al. (2015) Insertion Torque of Dental Implants after Microvascular Fibular Grafting. British Journal of Oral and Maxillofacial Surgery, 53, 647-649. [Google Scholar] [CrossRef] [PubMed]
[39] Kumar, V.V., Jacob, P.C., Ebenezer, S., et al. (2016) Implant Supported Dental Rehabilitation Following Segmental Mandibular Reconstruction-Quality of Life Outcomes of a Prospective Randomized Trial. Journal of Cranio-Maxillofacial Surgery, 44, 800-810. [Google Scholar] [CrossRef] [PubMed]
[40] Chang, Y.M., Pan, Y.H., Shen, Y.F., et al. (2016) Success of Dental Implants in Vascularised Fibular Osteoseptocutaneous Flaps Used as Onlay Grafts after Marginal Mandibulectomy. British Journal of Oral and Maxillofacial Surgery, 54, 1090-1094. [Google Scholar] [CrossRef] [PubMed]
[41] Kumar, V.V., Jacob, P.C. and Kuriakose, M.A. (2016) Sub-Periosteal Dissection with Denture-Guided Epithelial Regeneration: A Novel Method for Peri-Implant Soft Tissue Management in Reconstructed Mandibles. Journal of Maxillofacial and Oral Surgery, 15, 449-455. [Google Scholar] [CrossRef] [PubMed]
[42] Ernst, N., Sachse, C., Raguse, J.D., et al. (2016) Changes in Peri-Implant Bone Level and Effect of Potential Influential Factors on Dental Implants in Irradiated and Nonirradiated Patients Following Multimodal Therapy Due to Head and Neck Cancer: A Retrospective Study. Journal of Oral and Maxillofacial Surgery, 74, 1965-1973. [Google Scholar] [CrossRef] [PubMed]
[43] Sozzi, D., Novelli, G., Silva, R., et al. (2017) Implant Rehabilitation in Fibula-Free Flap Reconstruction: A Retrospective Study of Cases at 1-18 Years Following Surgery. Journal of Cranio-Maxillofacial Surgery, 45, 1655-1661. [Google Scholar] [CrossRef] [PubMed]
[44] Meloni, S.M., Tallarico, M., De Riu, G., et al. (2015) Guided Implant Surgery after Free-Flap Reconstruction: Four- Year Results from a Prospective Clinical Trial. Journal of Cranio-Maxillofacial Surgery, 43, 1348-1355. [Google Scholar] [CrossRef] [PubMed]
[45] Burgess, M., Leung, M., Chellapah, A., et al. (2017) Osseointegrated Implants into a Variety of Composite Free Flaps: A Comparative Analysis. Head Neck, 39, 443-447. [Google Scholar] [CrossRef] [PubMed]
[46] Wijbenga, J.G., Schepers, R.H., Werker, P.M., et al. (2016) A Systematic Review of Functional Outcome and Quality of Life Following Reconstruction of Maxillofacial Defects Using Vascularized Free Fibula Flaps and Dental Rehabilitation Reveals Poor Data Quality. Journal of Plastic, Reconstructive & Aesthetic Surgery, 69, 1024-1036. [Google Scholar] [CrossRef] [PubMed]
[47] Yoon, H.I. (2016) Prosthetic Rehabilitation after Fibular Free Flap Surgery of Mandibular Defects in a Patient with Oral Squamous Cell Carcinoma. Journal of Craniofacial Surgery, 27, e685-e688. [Google Scholar] [CrossRef
[48] Alberga, J.M., Vosselman, N., Korfage, A., et al. (2021) What Is the Optimal Timing for Implant Placement in Oral Cancer Patients? A Scoping Literature Review. Oral Diseases, 27, 94-110. [Google Scholar] [CrossRef] [PubMed]
[49] Shen, Y.F., Rodriguez, E.D., Wei, F.C., et al. (2015) Aesthetic and Functional Mandibular Reconstruction with Immediate Dental Implants in a Free Fibular Flap and a Low-Profile Reconstruction Plate: Five-Year Follow-Up. Annals of Plastic Surgery, 74, 442-446. [Google Scholar] [CrossRef
[50] Hakim, S.G., Kimmerle, H., Trenkle, T., et al. (2015) Masticatory Rehabilitation Following Upper and Lower Jaw Reconstruction Using Vascularised Free Fibula Flap and Enossal Implants-19 Years of Experience with a Comprehensive Concept. Clinical Oral Investigations, 19, 525-534. [Google Scholar] [CrossRef] [PubMed]
[51] Jacobsen, H.C., Wahnschaff, F., Trenkle, T., et al. (2016) Oral Rehabilitation with Dental Implants and Quality of Life Following Mandibular Reconstruction with Free Fibular Flap. Clinical Oral Investigations, 20, 187-192. [Google Scholar] [CrossRef] [PubMed]
[52] Zen Filho, E.V., Tolentino Ede, S. and Santos, P.S. (2016) Viability of Dental Implants in Head and Neck Irradiated Patients: A Systematic Review. Head Neck, 38, E2229-E2240. [Google Scholar] [CrossRef] [PubMed]
[53] Curi, M.M., Condezo, A.F.B., Ribeiro, K., et al. (2018) Long-Term Success of Dental Implants in Patients with Head and Neck Cancer after Radiation Therapy. International Journal of Oral and Maxillofacial Surgery, 47, 783-788. [Google Scholar] [CrossRef] [PubMed]
[54] Chrcanovic, B.R., Albrektsson, T. and Wennerberg, A. (2016) Dental Implants in Irradiated versus Nonirradiated Patients: A Meta-Analysis. Head Neck, 38, 448-481. [Google Scholar] [CrossRef] [PubMed]