四氧化三铁纳米粒子表面改性及生物相容性评价
Surface Modification and Biocompatibility Evaluation of Fe3O4 Nanoparticles
DOI: 10.12677/MS.2021.115070, PDF,    国家自然科学基金支持
作者: 孙文聪, 郝港桐, 陈俊英*, 翁亚军：西南交通大学材料先进技术教育部重点实验室，四川 成都；武迪蒙：成都德信安创新医疗技术有限公司，四川 成都
关键词: Fe3O4纳米粒子；表面改性；DGEA多肽；生物相容性；Fe3O4 Nanoparticles； Surface Modification； DGEA Polypeptide； Biocompatibility
摘要: Fe3O4纳米粒子(Fe3O4-NP)在生物医学领域发挥着越来越重要的作用。由于纳米粒子的独特性质，基于生物功能化的Fe3O4-NP表面改性是研究热点之一。因此，本文提出了一种新型的Fe3O4-NP表面改性的方法，将DGEA多肽与Fe3O4-NP结合，得到了具有良好生物相容性的改性Fe3O4-NP。傅里叶变换红外光谱、水合粒径等检测结果共同证明了DGEA多肽表面改性Fe3O4-NP的成功制备。体外血小板粘附实验与细胞学实验证实了其良好的生物相容性。该改性Fe3O4纳米粒子为Fe3O4纳米粒子的生物应用提供了一个良好的平台。
Abstract: Fe3O4 nanoparticles (Fe3O4-NP) are playing an increasingly important role in biomedical field. Be-cause of the unique properties of nanoparticles, the surface modification of Fe3O4-NP based on bi-ological functionalization is one of the research hotspots. Therefore, a new surface modification method of Fe3O4-NP was proposed in this paper. The modified Fe3O4-NP with good biocompatibility was obtained by combining DGEA polypeptide. FTIR, and hydrated particle size results proved the successful preparation of Fe3O4-NP modified by DGEA polypeptide. In vitro platelet adhesion activation test and cytological test confirmed its good biocompatibility. It provides a good platform for the biological application of Fe3O4 nanoparticles.
文章引用：孙文聪, 郝港桐, 陈俊英, 翁亚军, 武迪蒙. 四氧化三铁纳米粒子表面改性及生物相容性评价[J]. 材料科学, 2021, 11(5): 601-610. https://doi.org/10.12677/MS.2021.115070

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