肠道菌群与人体健康的研究进展
Research Progress of Intestinal Flora and Health
DOI: 10.12677/ACM.2021.115319, PDF,  被引量    科研立项经费支持
作者: 杨丽萍, 马文霞, 李 惠:青海大学研究生院,青海 西宁;马臻棋*, 王学红:青海大学附属医院消化内科,青海 西宁
关键词: 肠道菌群影响因素人体健康疾病Intestinal Flora Influence Factor Human Health Disease
摘要: 肠道菌群是在人体消化系统中蕴藏着的数万亿的微生物,其形成和增殖受多种因素的影响。近年来,随着宏基因组学研究的深入,人们对肠道菌群及其潜在作用的认识也日益加深。大量研究表明肠道菌群对人体健康有着很重要的作用,但当肠道菌群紊乱时可以改变肠道的通透性、消化和代谢以及免疫应答等,从而导致许多疾病的发生,本文阐明了影响肠道菌群的因素,并探讨了肠道菌群紊乱与人体健康、疾病之间的关系。
Abstract: Intestinal flora is a kind of trillions of microorganisms in human digestive system, whose formation and proliferation are affected by many factors. In recent years, with the development of metagenomics research, the understanding of intestinal flora and its potential role has been increasingly deepened. A large number of studies have shown that intestinal flora has a very important role to human body health, but when the intestinal flora disturbance can change the intestinal permeability, digestion and metabolism and the immune response, leading to many diseases, this paper expounds the factors that influence the intestinal flora and intestinal flora disturbance is discussed and the relationship between the human health and disease.
文章引用:杨丽萍, 马臻棋, 王学红, 马文霞, 李惠. 肠道菌群与人体健康的研究进展[J]. 临床医学进展, 2021, 11(5): 2221-2227. https://doi.org/10.12677/ACM.2021.115319

参考文献

[1] Quigley, E.M. (2013) Gut Bacteria in Health and Disease. Journal of Gastroenterology and Hepatology, 9, 560-569.
[2] Passos, M.D.C.F. and Moraes-Filho, J.P. (2017) Intestinal Microbiota in Digestive Diseases. Arquivos de Gastroenterologia, 54, 255-262. [Google Scholar] [CrossRef] [PubMed]
[3] Robles-Alonso, V. and Guarner, F. (2013) Progreso en el conocimiento de la microbiota intestinal humana [Progress in the Knowledge of the Intestinal Human Microbiota]. Nutrición Hospitalaria, 28, 553-557. (In Spanish) [Google Scholar] [CrossRef] [PubMed]
[4] Odamaki, T., Kato, K., Sugahara, H., Hashikura, N., Takahashi, S., Xiao, J.-Z., et al. (2016) Age-Related Changes in Gut Microbiota Composition from Newborn to Centenarian: A Cross-Sectional Study. BMC Microbiology, 16, Article No. 90. [Google Scholar] [CrossRef] [PubMed]
[5] Nagpal, R., Tsuji, H., Takahashi, T., Nomoto, K., Kawashima, K., Nagata, S., et al. (2017) Ontogenesis of the Gut Microbiota Composition in Healthy, Full-Term, Vaginally Born and Breast-Fed Infants over the First 3 Years of Life: A Quantitative Bird’s-Eye View. Frontiers in Microbiology, 8, Article No. 1388. [Google Scholar] [CrossRef] [PubMed]
[6] Hasan, N. and Yang, H. (2019) Factors Affecting the Composition of the Gut Microbiota, and Its Modulation. PeerJ, 7, e7502. [Google Scholar] [CrossRef] [PubMed]
[7] Krajmalnik-Brown, R., Ilhan, Z.E., Kang, D.W. and DiBaise, J.K. (2012) Effects of Gut Microbes on Nutrient Absorption and Energy Regulation. Nutrition in Clinical Practice, 27, 201-214. [Google Scholar] [CrossRef] [PubMed]
[8] Harvard T.H. Chan School of Public Health (n.d.) The Best Diet: Quality Counts.
https://www.hsph.harvard.edu/nutritionsource/healthy-weight/best-diet-quality-counts/#ref23
[9] Holscher, H.D. (2017) Dietary Fiber and Prebiotics and the Gastrointestinal Microbiota. Gut Microbes, 8, 172-184. [Google Scholar] [CrossRef] [PubMed]
[10] Schanche, M., Avershina, E., Dotterud, C., Øien, T., Storrø, O., Johnsen, R., et al. (2015) High-Resolution Analyses of Overlap in the Microbiota between Mothers and Their Children. Current Microbiology, 71, 283-290. [Google Scholar] [CrossRef] [PubMed]
[11] Biagi, E., Rampelli, S., Turroni, S., Quercia, S., Rampelli, S., Quercia, S., et al. (2017) The Gut Microbiota of Centenarians: Signatures of Longevity in the Gut Microbiota Profile. Mechanisms of Ageing and Development, 165, 180-184. [Google Scholar] [CrossRef] [PubMed]
[12] Lin, L. and Zhang, J. (2017) Role of Intestinal Microbiota and Metabolites on Gut Homeostasis and Human Diseases. BMC Immunology, 18, Article No. 2. [Google Scholar] [CrossRef] [PubMed]
[13] Thursby, E. and Juge, N. (2017) Introduction to the Human Gut Microbiota. Biochemical Journal, 474, 1823-1836. [Google Scholar] [CrossRef
[14] Louis, P. and Flint, H.J. (2017) Formation of Propionate and Butyrate by the Human Colonic Microbiota. Environ Environmental Microbiology, 19, 29-41. [Google Scholar] [CrossRef] [PubMed]
[15] Perry, R.J., Peng, L., Barry, N.A., Cline, G.W., Zhang, D., Cardone, R.L., et al. (2016) Acetate Mediates a Microbiome-Brain-β-Cell Axis to Promote Metabolic Syndrome. Nature, 534, 213-217. [Google Scholar] [CrossRef] [PubMed]
[16] LeBlanc, J.G., Milani, C., de Giori, G.S., Sesma, F., van Sinderen, D. and Ventura, M. (2013) Bacteria as Vitamin Suppliers to Their Host: A Gut Microbiota Perspective. Current Opinion in Biotechnology, 24, 160-168. [Google Scholar] [CrossRef] [PubMed]
[17] Forsythe, P., Sudo, N., Dinan, T., Taylor, V.H. and Bienenstock, J. (2010) Mood and Gut Feelings. Brain, Behavior, and Immunity, 24, 9-16. [Google Scholar] [CrossRef] [PubMed]
[18] Avoli, M. and Krnjević, K. (2016) The Long and Winding Road to Gamma-Amino-Butyric Acid as Neurotransmitter. Canadian Journal of Neurological Sciences, 43, 219-226. [Google Scholar] [CrossRef] [PubMed]
[19] Windey, K., De Preter, V. and Verbeke, K. (2012) Relevance of Protein Fermentation to Gut Health. Molecular Nutrition & Food Research, 56, 184-196. [Google Scholar] [CrossRef] [PubMed]
[20] Abdollahi-Roodsaz, S., Abramson, S.B. and Scher, J.U. (2016) The Metabolic Role of the Gut Microbiota in Health and Rheumatic Disease: Mechanisms and Interventions. Nature Reviews Rheumatology, 12, 446-455. [Google Scholar] [CrossRef] [PubMed]
[21] Bron, P.A., Kleerebezem, M., Brummer, R.J., Cani, P., Mercenier, A., MacDonald, T., et al. (2017) Can Probiotics Modulate Human Disease by Impacting Intestinal Barrier Function? British Journal of Nutrition, 117, 93-107. [Google Scholar] [CrossRef
[22] Morrison, D.J. and Preston, T. (2016) Formation of Short Chain Fatty Acids by the Gut Microbiota and Their Impact on Human Metabolism. Gut Microbes, 7, 189-200. [Google Scholar] [CrossRef] [PubMed]
[23] Bindels, L.B., Porporato, P., Dewulf, E.M., Verrax, J., Neyrinck, A.M., Martin, J.C., et al. (2012) Gut Microbiota-Derived Propionate Reduces Cancer Cell Proliferation in the Liver. British Journal of Cancer, 107, 1337-1344. [Google Scholar] [CrossRef] [PubMed]
[24] Yan, J., Herzog, J.W., Tsang, K., Brennan, C.A., Bower, M.A., Garrett, W.S., et al. (2016) Gut Microbiota Induce IGF-1 and Promote Bone Formation and Growth. Proceedings of the National Academy of Sciences of the United States of America, 113, E7554-E7563. [Google Scholar] [CrossRef] [PubMed]
[25] Weaver, C.M. (2015) Diet, Gut Microbiome, and Bone Health. Current Osteoporosis Reports, 13, 125-130. [Google Scholar] [CrossRef] [PubMed]
[26] Zemel, B.S. (2017) Dietary Calcium Intake Recommendations for Children: Are They Too High? American Journal of Clinical Nutrition, 105, 1025-1026. [Google Scholar] [CrossRef] [PubMed]
[27] Parvaneh, M., Karimi, G., Jamaluddin, R., Ng, M.H., Zuriati, I., Muhammad, S.I., et al. (2018) Lactobacillus helveticus (ATCC 27558) Upregulates Runx2 and Bmp2 and Modulates Bone Mineral Density in Ovariectomy-Induced Bone Loss Rats. Clinical Interventions in Aging, 13, 1555-1564. [Google Scholar] [CrossRef
[28] Chen, X., Eslamfam, S., Fang, L., Qiao, S. and Ma, X. (2017) Maintenance of Gastrointestinal Glucose Homeostasis by the Gut-Brain Axis. Current Protein & Peptide Science, 18, 541-547. [Google Scholar] [CrossRef] [PubMed]
[29] Soty, M., Gautier-Stein, A., Rajas, F, and Mithieux, G. (2017) Gut-Brain Glucose Signaling in Energy Homeostasis. Cell Metabolism, 25, 1231-1242. [Google Scholar] [CrossRef] [PubMed]
[30] Mohajeri, M.H., La Fata, G., Steinert, R.E. and Weber, P. (2018) Relationship between the Gut Microbiome and Brain Function. Nutrition Reviews, 76, 481-496. [Google Scholar] [CrossRef] [PubMed]
[31] Sampson, T.R. and Mazmanian, S.K. (2015) Control of Brain Development, Function, and Behavior by the Microbiome. Cell Host & Microbe, 17, 565-576. [Google Scholar] [CrossRef] [PubMed]
[32] Jaacks, L.M., Vandevijvere, S., Pan, A., McGowan, C.J., Wallace, C., Imamura, F., et al. (2019) The Obesity Transition: Stages of the Global Epidemic. Lancet Diabetes & Endocrinology, 7, 231-240. [Google Scholar] [CrossRef
[33] Andoh, A., Nishida, A., Takahashi, K., Inatomi, O., Imaeda, H., Bamba, S., et al. (2016) Comparison of the Gut Microbial Community between Obese and Lean Peoples Using 16S Gene Sequencing in a Japanese Population. Journal of Clinical Biochemistry and Nutrition, 59, 65-70. [Google Scholar] [CrossRef] [PubMed]
[34] Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., et al. (2012) A Metagenome-Wide Association Study of Gut Microbiota in Type 2 Diabetes. Nature, 490, 55-60. [Google Scholar] [CrossRef] [PubMed]
[35] Zou, J., Chassaing, B., Singh, V., Pellizzon, M., Ricci, M., Fythe, M.D., et al. (2018) Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health. Cell Host & Microbe, 23, 41-53.e4. [Google Scholar] [CrossRef] [PubMed]
[36] Zhao, L., Zhang, F., Ding, X., Wu, G., Lam, Y.Y., Wang, X., et al. (2018) Gut Bacteria Selectively Promoted by Dietary Fibers Alleviate Type 2 Diabetes. Science, 359, 1151-1156. [Google Scholar] [CrossRef] [PubMed]
[37] Garcia-Rios, A., Torres-Peña, J.D., Perez-Jimenez, F. and Perez-Martinez, P. (2017) Gut Microbiota: A New Marker of Cardiovascular Disease. Current Pharmaceutical Design, 23, 3233-3238. [Google Scholar] [CrossRef] [PubMed]
[38] Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., et al. (2018) Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. New England Journal of Medicine, 378, e34. [Google Scholar] [CrossRef
[39] Zhu, W., Gregory, J.C., Org, E., Buffa, J.A., Guptam N., Wang, Z., et al. (2016) Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell, 165, 111-124. [Google Scholar] [CrossRef] [PubMed]
[40] Griffin, J.L., Wang, X. and Stanley, E. (2015) Does Our Gut Microbiome Predict Cardiovascular Risk? A Review of the Evidence from Metabolomics. Circulation: Cardiovascular Genetics, 8, 187-191. [Google Scholar] [CrossRef
[41] Lane, E.R., Zisman, T.L. and Suskind, D.L. (2017) The Microbiota in Inflammatory Bowel Disease: Current and therapeutic Insights. Journal of Inflammation Research, 10, 63-73. [Google Scholar] [CrossRef
[42] Parekh, P.J., Balart, L.A. and Johnson, D.A. (2015) The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease. Clinical and Translational Gastroenterology, 6, e91. [Google Scholar] [CrossRef] [PubMed]
[43] Bennet, S.M., Ohman, L. and Simren, M. (2015) Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome. Gut and Liver, 9, 318-331. [Google Scholar] [CrossRef] [PubMed]
[44] Leung, C., Rivera, L., Furness, J.B. and Angus, P.W. (2016) The Role of the Gut Microbiota in NAFLD. Nature Reviews Gastroenterology & Hepatology, 13, 412-425. [Google Scholar] [CrossRef] [PubMed]
[45] Pevsner-Fischer, M., Tuganbaev, T., Meijer, M., Zhang, S.-H., Zeng, Z.-R., Chen, M.-H., et al. (2016) Role of the Microbiome in Non-Gastrointestinal Cancers. World Journal of Clinical Oncology, 7, 200-213. [Google Scholar] [CrossRef] [PubMed]