抗癫痫药物对癫痫患者脂代谢影响的研究进展
Research Progress on the Effect of Antiepileptic Drugs on Lipid Metabolism in Patients with Epilepsy
DOI: 10.12677/ACM.2021.115326, PDF,   
作者: 杜 苗, 高学军：延安大学附属医院神经内科，陕西 延安
关键词: 抗癫痫药物；脂代谢；Antiepileptic Drugs； Lipid Metabolism
摘要: 癫痫是中枢神经系统的常见疾病之一，绝大多数的患者都需要长期AEDs治疗，长期AEDs治疗对患者脂代谢的影响在临床上较少引起重视，及早的监测癫痫患者血脂指标，对于有效防治癫痫患者脂代谢异常、预防因血脂异常引起的一系列血管事件具有重要意义。本文主要以新型AEDs对体重、血脂指标的影响及其可能影响脂代谢的作用机制等方面阐述其对脂代谢的影响，为癫痫患者预防脂代谢异常提供一些理论依据。
Abstract: Epilepsy is one of the common diseases of the central nervous system. The vast majority of patients require long-term AEDs treatment. The effect of long-term AEDs treatment on patients’ lipid metabolism has received little clinical attention. Early monitoring of blood lipid indexes in patients with epilepsy is useful for effective prevention and treatment. It is of great significance for epilepsy patients to have abnormal lipid metabolism and prevent a series of vascular events caused by dyslipidemia. This article mainly discusses the effect of new AEDs on body weight and blood lipid indexes and the mechanism of its possible effect on lipid metabolism, and provides some theoretical basis for preventing abnormal lipid metabolism in patients with epilepsy.
文章引用：杜苗, 高学军. 抗癫痫药物对癫痫患者脂代谢影响的研究进展[J]. 临床医学进展, 2021, 11(5): 2261-2265. https://doi.org/10.12677/ACM.2021.115326

参考文献

[1] Thijs, R.D., Surges, R., O’Brien, T.J. and Sander, J.W. (2019) Epilepsy in Adults. The Lancet, 393, 689-701. [Google Scholar] [CrossRef] 
[2] Scheffer, I.E., Berkovic, S., Capovilla, G., et al. (2017) ILAE Classification of the Epilepsies: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia, 58, 512-521. [Google Scholar] [CrossRef] [PubMed]
[3] Aynaci, F.M., Orhan, F., Orem, A., et al. (2001) Effect of Antiepileptic Drugs on Plasma Lipoprotein(a) and Other Lipid Levels in Childhood. Journal of Child Neurology, 16, 367-369. [Google Scholar] [CrossRef] [PubMed]
[4] 陈夏. 卡马西平及奥卡西平对成人癫痫患者血管疾病危险因素的影响[D]: [硕士学位论文]. 南昌: 南昌大学, 2012.
[5] Antel, J. and Hebebrand, J. (2012) Weight-Reducing Side Effects of the Antiepileptic Agents Topiramate and Zonisamide. In: Joost, H.-G., Ed., Appetite Control, Handbook of Experimental Pharmacology Book Series (HEP), Volume 209, Springer, Berlin, 433-466. [Google Scholar] [CrossRef] [PubMed]
[6] 卢军, 曾其昌, 王琴, 彭琼, 黄亚辉. 托吡酯与丙戊酸钠对癫痫患儿脑电活动及糖脂代谢的影响[J]. 现代生物医学进展, 2016, 16(28): 5546-5548+5571.
[7] Ozcelik, A.A., Serdaroglu, A., Bideci, A., et al. (2014) The Effect of Topiramate on Body Weight and Ghrelin, Leptin, and Neuropeptide-Y Levels of Prepubertal Children with Epilepsy. Pediatric Neurology, 51, 220-224. [Google Scholar] [CrossRef] [PubMed]
[8] 陈亚南, 徐善森, 邱枫, 等. 钠离子通道基因与转运体基因多态性对拉莫三嗪血药浓度的影响[J]. 中国临床药理学杂志, 2016, 32(22): 2069-2072.
[9] Mintzer, S., Trinka, E., Kraemer, G., Chervoneva, I. and Werhahn, K.J. (2018) Impact of Carbamazepine, Lamotrigine, and Levetiracetam on Vascular Risk Markers and Lipid-Lowering Agents in the Elderly. Epilepsia, 59, 1899-1907. [Google Scholar] [CrossRef] [PubMed]
[10] Zuberi, N.A., Baig, M., Bano, S., et al. (2017) Assessment of Atherosclerotic Risk among Patients with Epilepsy on Valproic Acid, Lamotrigine, and Carbamazepine Treatment. Neurosciences (Riyadh), 22, 114-118. [Google Scholar] [CrossRef] [PubMed]
[11] 翟明明, 李昭盈. 拉莫三嗪对癫痫患者脂代谢与预后影响研究[J]. 临床军医杂志, 2019, 47(8): 873-874.
[12] 修成涛. 拉莫三嗪联合丙戊酸对癫痫患者脂代谢指标及认知功能的影响[J]. 河南医学研究, 2017, 26(16): 2928-2930.
[13] 朱星阳. 拉莫三嗪联合丙戊酸治疗癫痫的临床疗效及其对患者认知功能及脂代谢的影响分析[J]. 数理医药学杂志, 2020, 33(12): 1818-1820.
[14] 石莺, 彭汉芬. 拉莫三嗪联合丙戊酸治疗癫痫的临床疗效及其对患者认知功能及脂代谢的影响[J]. 临床合理用药杂志, 2018, 11(12): 44-46.
[15] 温玉梅, 刘秀娟, 刘晓宇, 徐明侠. 拉莫三嗪联合丙戊酸治疗癫痫的临床疗效[J]. 海南医学院学报, 2016, 22(8): 816-818.
[16] Ley, M., Principe, A. and Rocamora, R. (2020) Efectos a largo plazo de las dibenzacepinas sobre los parámetros metabólicos: Comparación retrospectiva de carbamacepina, oxcarbacepina y acetato de eslicarbacepina en el mundo real [Long-Term Effects of Dibenzazepines on Metabolic Parameters: Retrospective Comparison of Carbamazepine, Oxcarbazepine and Eslicarbazepine Acetate in the Real World]. Revue Neurologique, 71, 54-60. [Google Scholar] [CrossRef] [PubMed]
[17] Garoufi, A., Koemtzidou, E., Katsarou, E., et al. (2014) Lipid Profile and Thyroid Hormone Concentrations in Children with Epilepsy Treated with Oxcarbazepine Monotherapy: A Prospective Long-Term Study. European Journal of Neurology, 21, 118-123. [Google Scholar] [CrossRef] [PubMed]
[18] Attilakos, A., Dinopoulos, A., Tsirouda, M., et al. (2019) Effect of Levetiracetam Monotherapy on Lipid Profiles and Thyroid Hormones in Children with Epilepsy: A Prospective Study. Epilepsy Research, 155, Article ID: 106162. [Google Scholar] [CrossRef] [PubMed]
[19] Nishiyama, M., Takami, Y., Ishida, Y., et al. (2019) Lipid and Thyroid Hormone Levels in Children with Epilepsy Treated with Levetiracetam or Carbamazepine: A Prospective Observational Study. Epilepsy & Behavior, 90, 15-19. [Google Scholar] [CrossRef] [PubMed]
[20] 李静, 刘文萍. 卡马西平与左乙拉西坦对癫痫的疗效和对血脂、骨代谢的影响比较[J]. 神经损伤与功能重建, 2018, 13(5): 260-262.
[21] El-Farahaty, R.M., El-Mitwalli, A., Azzam, H., Wasel, Y., Elrakhawy, M.M. and Hasaneen, B.M. (2015) Atherosclerotic Effects of Long-Term Old and New Antiepileptic Drugs Monotherapy: A Cross-Sectional Comparative Study. Journal of Child Neurology, 30, 451-457. [Google Scholar] [CrossRef] [PubMed]
[22] 周小龙, 张鹏. 传统抗癫痫药物与新抗癫痫药物对癫痫患者身体成分及脂代谢的影响[J]. 实用药物与临床, 2017, 20(4): 419-423.
[23] 朱彩华, 刘阳, 张淼, 等. 左乙拉西坦与卡马西平对癫痫儿童情绪行为和骨代谢脂代谢的影响[J]. 安徽医学, 2019, 40(10): 1115-1118.
[24] 叶静萍. 托吡酯与丙戊酸钠对癫痫患儿体质量、糖代谢影响的临床观察[J]. 中国药房, 2015, 26(6): 740-742.
[25] Manzini, S., Busnelli, M., Parolini, C., et al. (2019) Topiramate Protects apoE-Deficient Mice from Kidney Damage without Affecting Plasma Lipids. Pharmacological Research, 141, 189-200. [Google Scholar] [CrossRef] [PubMed]
[26] Kim, D.W., Lee, S.Y., Shon, Y.M., et al. (2013) Effects of New Antiepileptic Drugs on Circulatory Markers for Vascular Risk in Patients with Newly Diagnosed Epilepsy. Epilepsia, 54, e146-e149. [Google Scholar] [CrossRef] [PubMed]
[27] Benedetti, M.S. (2000) Enzyme Induction and Inhibition by New Antiepileptic Drugs: A Review of Human Studies. Fundamental & Clinical Pharmacology, 14, 301-319. [Google Scholar] [CrossRef] [PubMed]
[28] 黄从刚, 卞红强, 罗正利, 等. 左乙拉西坦和托吡酯治疗癫痫疗效和安全性的系统评价[J]. 中华神经医学杂志, 2014, 13(5): 499-503.
[29] Mintzer, S., Miller, R., Shah, K., et al. (2016) Long-Term Effect of Antiepileptic Drug Switch on Serum Lipids and C-Reactive Protein. Epilepsy & Behavior, 58, 127-132. [Google Scholar] [CrossRef] [PubMed]

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