高同型半胱氨酸血症患者颈动脉内膜中层厚度与冠心病的相关性及血运重建预测价值
Correlation between Carotid Intima-Media Thickness and Coronary Heart Disease in Patients with Hyperhomocysteinemia and Predictive Value of Revascularization
DOI: 10.12677/ACM.2021.115337, PDF,   
作者: 于 航, 阮士苗：青岛大学，山东 青岛；于 方：济宁市第一人民医院，山东 济宁；刘 松, 蔡尚郎, 张文忠：青岛大学附属医院心内科，山东 青岛
关键词: 高同型半胱氨酸血症；冠心病；颈动脉内膜中层厚度；Hyperhomocysteinemia； Coronary Heart Disease； Carotid Intima-Media Thickness
摘要: 目的：探讨高同型半胱氨酸血症患者动脉内膜中层厚度与冠状动脉粥样硬化严重程度的相关性，并分析血运重建临床预测价值。方法：本研究纳入167例高同型半胱氨酸血症患者，行颈部血管超声、冠状动脉造影检查(Coronary angiography, CAG)以及相关检验，计算Gensini积分和Leaman积分。根据CAG结果分为血运重建组81例，药物保守治疗组86例，应用受试者工作特征曲线(receiver operating curve, ROC)对血运重建组患者进行分析。结果：Crouse积分与Gensini积分和Leaman积分之间均呈现正相关表现，其相关系数分别是0.5303，0.57。CIMT的预测冠脉血运重建的概率AUC = 0.767。结论：高同型半胱氨酸血症患者颈动脉斑块与冠心病存在相关性，颈动脉斑块的有无对冠脉血运重建具有预测价值。
Abstract: Objective: Investigate the relationship between the thickness of the arterial intima-media and the severity of coronary atherosclerosis in patients with hyperhomocysteinemia, and analyze the clinical predictive value of revascularization. Methods: This study included 167 patients with hyperhomocysteinemia who underwent cervical vascular ultrasound, coronary angiography (CAG) and related tests, and calculated Gensini points and Leaman points. According to CAG results, they were divided into 81 cases in the revascularization group and 86 cases in the drug conservative group, and receiver operating curve (ROC) was used to analyze patients in revascularization group. Results: There was a positive correlation between Crouse points, Gensini points and Leaman points, and the correlation coefficients were 0.5303, 0.57, respectively. CIMT predicted the probability of coronary revascularization AUC = 0.767. Conclusion: There is a correlation between carotid plaque and coronary heart disease in patients with hyperhomocysteinemia. The presence or absence of carotid plaque has predictive value for coronary revascularization.
文章引用：于航, 于方, 刘松, 蔡尚郎, 阮士苗, 张文忠. 高同型半胱氨酸血症患者颈动脉内膜中层厚度与冠心病的相关性及血运重建预测价值[J]. 临床医学进展, 2021, 11(5): 2341-2349. https://doi.org/10.12677/ACM.2021.115337

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