PDGF促进骨折愈合的研究进展
Research Progress of PDGF in Promoting Fracture Healing
DOI: 10.12677/ACM.2021.115342, PDF,   
作者: 王亚楠：青海大学研究生院，青海 西宁；曹志强*：青海大学附属医院，青海 西宁
关键词: PDGF；骨折愈合；PDGF； Fracture Healing
摘要: 骨折的愈合问题是骨科医师长久以来关心的问题，骨折愈合是骨组织完全性再生的过程，各种细胞因子在不同的骨折愈合阶段发挥不同的作用；随着外科技术的不断成熟与完善，目前仍有约10%的骨折病人存在骨折不愈合或延迟愈合的情况。近年来，有相关研究表明，血小板衍生生长因子(PDGF)对于骨折不愈合或延迟愈合病人有着良好的促进骨折愈合作用。PDGF作为一种有效的有丝分裂原，对包括成骨系细胞在内的多种间充质细胞有刺激作用。对于PDGF的进一步研究，能够对临床骨折患者提供新的更优的选择。本文就PDGF促进骨折愈合机制以及研究进展作一综述。
Abstract: Fracture healing is a process of complete regeneration of bone tissue. Various cytokines play different roles in different stages of fracture healing. With the continuous maturity and improvement of surgical technology, about 10% of fracture patients still have nonunion or delayed union. In recent years, related studies have shown that platelet-derived growth factor (PDGF) has a good effect on promoting fracture healing in patients with nonunion or delayed union. As an effective mitogen, PDGF can stimulate a variety of mesenchymal cells including osteoblasts. The further study of PDGF can provide a new and better choice for clinical fracture patients. This article reviews the mechanism and research progress of PDGF in promoting fracture healing.
文章引用：王亚楠, 曹志强. PDGF促进骨折愈合的研究进展[J]. 临床医学进展, 2021, 11(5): 2381-2386. https://doi.org/10.12677/ACM.2021.115342

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