三种血清蛋白因子在结直肠癌早期诊断中的意义
Significance of Three Serum Protein Factors in Early Diagnosis of Colorectal Carcinoma
DOI: 10.12677/ACM.2021.115344, PDF,    科研立项经费支持
作者: 冯盼盼：青海大学研究生院，青海 西宁；芦永福*, 王学红：青海大学附属医院消化内科，青海 西宁
关键词: 乳铁蛋白；环氧化酶-2；内皮细胞特异性分子-1；结直肠癌；临床意义；Lactoferrin； Cyclooxygenase-2； Endothelial Cell Specific Molecule-1； Colorectal Carcinoma； Clinical Interpretation
摘要: 近年来，结直肠癌逐渐成为我国肿瘤疾病死亡的主要原因之一，尽管结直肠癌的诊断和预后方面不断进展，但早期检测筛查方法仍需改进，还需确定新的生物标志物。目前较多研究发现乳铁蛋白、环氧化酶-2、内皮细胞特异性分子-1与结直肠癌的发生、发展密切相关，本文就其三种蛋白因子在结直肠癌中的表达及意义作一探讨。
Abstract: For the past few years, colorectal cancer has gradually become one of the leading causes of cancer-related death in China. Despite continued progress in the diagnosis and prognosis of colorectal cancer, early detection and screening methods still need to be improved, new biomarkers need to be identified. At present, many studies have found that lactoferrin, COX-2 and endothelium specific molecule-1 are closely related to the occurrence and development of colorectal cancer. This article will discuss the expression and significance of lactoferrin, COX-2 and endothelial specific molecule-1 in colorectal cancer.
文章引用：冯盼盼, 芦永福, 王学红. 三种血清蛋白因子在结直肠癌早期诊断中的意义[J]. 临床医学进展, 2021, 11(5): 2392-2397. https://doi.org/10.12677/ACM.2021.115344

参考文献

[1] Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., et al. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. [Google Scholar] [CrossRef] [PubMed]
[2] 中华医学会消化病学分会. 中国早期结直肠癌及癌前病变筛查与诊治共识[J]. 中国医刊, 2015, 1(11): 124-140.
[3] 李娜, 李宏斌, 朱蕾, 赵车冬, 刘军辉. 血清CEA、CA199和CA153检测对判定结肠癌发生发展的价值分析[J]. 实用癌症杂志, 2016, 31(3): 396-398.
[4] Farnaud, S. and Evans, R.W. (2003) Lactoferrin—A Multifunctional Protein with Antimicrobial Properties. Molecular Immunology, 40, 395-405. [Google Scholar] [CrossRef] 
[5] 陈晓泓, 张博恒. 乳铁蛋白在肿瘤治疗中的作用机制[J]. 复旦学报(医学版), 2010, 37(1):119-121.
[6] 岳硕豪, 田弛, 胡元昭, 张军林. 抗癌肽研究进展[J]. 生物技术通报, 2017, 33(11): 41-47.
[7] 王晓君. miRNA-214通过靶向β-catenin通路抑制肝癌生长[D]: [博士学位论文]. 福州: 福建医科大学, 2013.
[8] Kuhara, T., Itoh, T., et al. (2000) Orally Administered Lactoferrin Exerts an Antimetastatic Effect and Enhances Production of IL-18 in the Intestinal Epithelium. Nutrition and Cancer, 38, 192-199. [Google Scholar] [CrossRef] 
[9] Xiao, Y., et al. (2004) Lactoferrin Down-Regulates G1 Cyclin-Dependent Kinases during Growth Arrest of Head and Neck Cancer Cells. Clinical Cancer Research, 10, 8683-8686. [Google Scholar] [CrossRef] 
[10] Lee, S.-H., et al. (2009) Requirement of the JNK-Associated Bcl-2 Pathway for Human Lactoferrin-Induced Apoptosis in the Jurkat Leukemia T Cell Line. Biochimie, 91, 102-108. [Google Scholar] [CrossRef] [PubMed]
[11] Fujita, K.-I., et al. (2004) Lactoferrin Modifies Apoptosis-Related Gene Expression in the Colon of the Azoxymethane-Treated Rat. Cancer Letters, 213, 21-29. [Google Scholar] [CrossRef] [PubMed]
[12] 吴雪芳, 李霜, 胡建军, 杨迎春, 龙艳丽, 王剑, 易韦. 结直肠癌中K-RAS基因突变与p53蛋白表达的临床意义及相关性[J]. 临床与实验病理学杂志, 2020, 36(10): 1215-1218.
[13] Mazurek, S., et al. (2005) Pyruvate Kinase Type M2 and Its Role in Tumor Growth and Spreading. Seminars in Cancer Biology, 15, 300-308. [Google Scholar] [CrossRef] [PubMed]
[14] Wang, D.Z. and DuBois, R.N. (2010) Eicosanoids and Cancer. Nature Reviews Cancer, 10, 181-193. [Google Scholar] [CrossRef] [PubMed]
[15] Garcia-Villatoro Erika, L., et al. (2020) Effects of High-Fat Diet and Intestinal Aryl Hydrocarbon Receptor Deletion on Colon Carcinogenesis. American Journal of Physiology. Gastrointestinal and Liver Physiology, 318, G451-G463. [Google Scholar] [CrossRef] [PubMed]
[16] 陈瀚宇, 王锡山. 大肠癌预防中非甾体抗炎药的新靶点及新药物的研究[J]. 中华结直肠疾病电子杂志, 2013, 2(3): 123-126.
[17] Lüftner, D., et al. (2000) Tumor Type M2 Pyruvate Kinase Expression in Advanced Breast Cancer. Anticancer Research, 20, 5077-5082.
[18] Albasri, A.M., et al. (2018) Impact of Cyclooxygenase-2 Over-Expression on the Prognosis of Colorectal Cancer Patients. An Experience from Western Saudi Arabia. Saudi Medical Journal, 39, 773-780. [Google Scholar] [CrossRef] [PubMed]
[19] Yang, Y., et al. (2020) Serum Levels of PTEN mRNA in Colorectal Cancer: A Case-Control Study. Artificial Cells, Nanomedicine, and Biotechnology, 48, 789-793. [Google Scholar] [CrossRef] [PubMed]
[20] 常剑, 陶京, 朱忠超, 方琦, 李汉军, 朱孔凡. 花生四烯酸通过COX-2酶代谢氧化失活PTEN促进结直肠癌生长[J]. 现代生物医学进展, 2020, 20(21): 4001-4006.
[21] Soichiro, H., et al. (2005) COX-2 Inhibitor, NS398, Enhances Fas-Mediated Apoptosis via Modulation of the PTEN-Akt Pathway in Human Gastric Carcinoma Cell Lines. DNA and Cell Biology, 24, 141-147. [Google Scholar] [CrossRef] [PubMed]
[22] Tsujii, M. and Dubios, R.N. (1995) Alterations in Cellular Adhesion and Apoptosis in Epithelial Cells Overexpressing Prostaglandin Endoperoxide Synthase 2. Cell, 83, 493-501. [Google Scholar] [CrossRef] [PubMed]
[23] Yang, W.L., et al. (2018) Value of Combined Detection of Serum Carcino-Embryonic Antigen, Carbohydrate Antigen 19-9 and Cyclooxygenase-2 in the Diagnosis of Colorectal Cancer. Oncology Letters, 16, 1551-1556. [Google Scholar] [CrossRef] [PubMed]
[24] 张伟, 马晓龙, 艾建中. FBXW7及c-Myc蛋白在人胃癌组织中的表达及其与胃癌临床病理特征的相关性分析[J]. 临床和实验医学杂志, 2018, 17(7): 751-754.
[25] 李世龙, 张宝, 宋扬, 吴丹, 牛蕊, 秦莉. 血清ESM-1和CEA及CA199检测对结直肠癌诊断价值探讨[J]. 中华肿瘤防治杂志, 2019, 26(15): 1119-1123.
[26] 张欣霞, 陈婷, 涂盛, 姚定国. 胰岛素信号通路与肿瘤风险相关性的研究进展[J]. 浙江中医药大学学报, 2015, 39(5): 418-422.
[27] Li, F.C., et al. (2008) Involvement of Highly Sulfated Chondroitin Sulfate in the Metastasis of the Lewis Lung Carcinoma Cells. Journal of Biological Chemistry, 283, 34294-34304. [Google Scholar] [CrossRef] 

为你推荐