Ki-67在肝细胞癌并微血管癌栓中表达的意义

Significance of Ki-67 Expression in Hepatocellular Carcinoma with Microvascular Tumor Thrombus

摘要: 目的：探讨Ki-67在肝细胞癌微血管侵犯(微血管侵犯：MVI)中表达的意义。方法：对青岛大学附属医院从2013年1月到2020年6月进行的约680例行根治性肝切除手术并确诊为肝细胞癌的患者的临床及病理资料进行回顾性分析。结果：这680例患者中，MVI阳性的患者占53.2% (362/680)。通过单因素分析，发现MVI的发生与Ki-67阳性有关，此外还有患者的年龄、性别、饮酒史、术前白蛋白、甲胎蛋白(AFP)、癌抗原125 (CA125)、谷草转氨酶(AST)、γ-谷氨酰转肽酶、肿瘤最大直径、肿瘤数目、是否存在卫星结节与MVI的发生有关(均P < 0.05)。多因素Logistic回归分析结果显示：Ki-67是MVI的独立危险因素。MVI的其他独立危险因素还包括AST、性别，肿瘤直径 > 3 cm，存在卫星结节(均P < 0.05)。结论：Ki-67的高表达(≥20%)与MVI的发生有关。

Abstract: Objective: To investigate the significance of Ki-67 expression in microvascular invasion (MVI) of HCC. Methods: The clinical and pathological data of 680 patients with liver cancer diagnosed as HCC were analyzed retrospectively from January 2013 to June 2020 in the Affiliated Hospital of Qingdao University. Results: Among the 680 patients, 53.2% (362/680) of the patients were with MVI positive. The results showed that MVI was related to Ki-67 positive by single factor analysis. In addition, the age, sex, drinking history, preoperative albumin, AFP, CA125, AST, and the age of the patients, γ-glutamyl transpeptidase, the largest diameter of tumor, the number of tumors and the presence of satellite nodules were also observed related to the occurrence of MVI (P < 0.05). The results of multivariate logistic regression analysis showed that Ki-67 was an independent risk factor for MVI. Other independent risk factors of MVI included AST, sex, tumor diameter > 3 cm, satellite nodule (P < 0.05). Conclusion: The high expression of Ki-67 (≥20%) is associated with MVI.