瘢痕疙瘩的治疗研究进展
Research Progress on the Treatments of Keloids
DOI: 10.12677/ACM.2021.116366, PDF,   
作者: 胡 超：浙江中医药大学，浙江 杭州
关键词: 瘢痕疙瘩；发病机制；治疗方法；预防；Keloid； Pathogenesis； Treatment； Prevention
摘要: 瘢痕疙瘩(keloid)是目前在整形外科、皮肤科常见的一种疾病，本文将从当前对瘢痕疙瘩的发病机制的研究进展、其医治方法、预防方法等方面进行阐述，从而分析当前在瘢痕疙瘩治疗方面各种治疗手段的利弊，并讨论了对于瘢痕疙瘩医治的远景。
Abstract: Keloid is a common disease in plastic surgery and dermatology. In this paper, the current research progress on the pathogenesis of keloid, its treatment methods, prevention methods and other aspects are described, so as to analyze the advantages and disadvantages of various treatments of keloid, and discuss the prospects of keloid treatment.
文章引用：胡超. 瘢痕疙瘩的治疗研究进展[J]. 临床医学进展, 2021, 11(6): 2547-2552. https://doi.org/10.12677/ACM.2021.116366

参考文献

[1] Marneros, A.G., Norris, J.E., Watanabe, S., et al. (2004) Genome Scans Provide Evidence for Keloid Susceptibility Loci on Chromosomes 2q23 and 7p11. Journal of Investigative Dermatology, 122, 1126-1132. [Google Scholar] [CrossRef] 
[2] 刘晓军, 高建华, 宋玫, 等. 中国汉族瘢痕疙瘩家系易感基因位点的定位分析[J]. 中国组织工程研究与临床康复, 2008, 12(37): 7241-7244.
[3] Sidgwick, G.P. and Bayat, A. (2012) Extracellular Matrix Molecules Implicated in Hypertrophic and Keloid Scarring. The Journal of the European Academy of Dermatology and Venereology, 26, 141-152. [Google Scholar] [CrossRef] [PubMed]
[4] Bock, O., Yu, H., Zitron, S., et al. (2005) Studies of Transforming Growth Factors Beta 1-3 and Their Receptors I and II in Fibroblast of Keloids and Hypertrophic Scars. Acta Dermato-Venereologica, 85, 216-220. [Google Scholar] [CrossRef] [PubMed]
[5] 秦泽莲. 增生性瘢痕异常增生的启动机制[J]. 中华整形外科杂志, 2002, 19(2): 135-137.
[6] Xu, L.G., Sun, N., Li, G.S. and Liu, L.B. (2021) LncRNA H19 Promotes Keloid Formation through Targeting the miR-769-5p/EIF3A Pathway. Molecular and Cellular Biochemistry, 476, 1477-1487.
[7] Lv, W.C., Liu S.X., Zhang, Q., Yi, Z., Bao, X.Y., Feng, Y.P. and Ren, Y.P. (2021) Downregulation of Epac Reduces Fibrosis and Induces Apoptosis through Akt Signaling in Human Keloid Fibroblasts. Journal of Surgical Research, 257, 306-316. [Google Scholar] [CrossRef] [PubMed]
[8] Wang, X.M., Liu, X.M., Wang, Y.T. and Chen, Z.Y. (2020) Activating Transcription Factor 3 (ATF3) Regulates Cell Growth, Apoptosis, Invasion and Collagen Synthesis in Keloid Fibroblast through Transforming Growth Factor Beta (TGF-Beta)/SMAD Signaling Pathway. Bioengineered, 12, 117-126. [Google Scholar] [CrossRef] [PubMed]
[9] 郑秀芬, 何仁亮, 黄桃源, 朱定衡, 胡勇, 王瑞华, 汤红峰. 自体瘢痕皮回植联合局部注射等治疗胸前巨大瘢痕疙瘩的疗效观察[J/OL]. 中国皮肤性病学杂志, 2021: 1-9.
https://kns.cnki.net/kcms/detail/detail.aspx?doi=10.13735/j.cjdv.1001-7089.202002182, 2021-02-03.
[10] Berman, B., Maderal, A. and Raphael, B. (2017) Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment. Dermatologic Surgery, 43, S3-S18. [Google Scholar] [CrossRef] 
[11] 陈立彬, 武晓莉, 陈宗安, Won Tehao, 高振. 瘢痕整形手术中的减张缝合技巧[J]. 组织工程与重建外科杂志, 2019, 15(2): 63-64.
[12] 曹婷, 韩文娟, 韩莹. 术后放疗联合局部加压治疗耳部瘢痕疙瘩疗效分析[J]. 中国美容医学, 2020, 29(4): 20-23.
[13] 陈诚, 余睿芳, 张宝林. 无针注射器治疗瘢痕疙瘩的疗效研究[J]. 中国美容医学, 2020, 29(3): 82-87.
[14] 胡小桃, 李薇. 苦参碱联合氢化可的松对瘢痕疙瘩成纤维细胞的影响[J]. 中国临床药理学杂志, 2020, 36(14): 2107-2110.
[15] 古芝燕, 陈晓娟, 李俊茹. 不同浓度曲安奈德局部注射联合手术切除治疗面部瘢痕疙瘩[J]. 中国美容医学, 2019, 28(7): 79-81.
[16] 叶亮, 易阳艳, 王江文. A型肉毒毒素防治病理性瘢痕的临床研究进展[J]. 实用医学杂志, 2021, 37(4): 538-541.
[17] 王镜涵, 白欣冉, 董彦慧, 曹哲, 崔久林, 梁晓琴. A型肉毒素与曲安奈德治疗瘢痕疙瘩的长期疗效对比[J]. 中国皮肤性病学杂志, 2019, 33(10): 1149-1152.
[18] 刘欣健, 崔正军, 张树堂, 苏卫国, 孟庆楠, 郭鹏飞, 魏爱周, 周健, 王常印, 邹仕波, 孙佳琳, 王旭. 曲安奈德联合5-氟尿嘧啶与单独曲安奈德治疗瘢痕疙瘩效果的荟萃分析[J]. 中华烧伤杂志, 2020, 36(12): 1191-1198.
[19] Ouyang, H.W., Li, G.F., Lei, Y., et al. (2018) Comparison of the Effectiveness of Pulsed Dye Laser vs Pulsed Dye Laser Combined with Ultrapulse Fractional CO2 Laser in the Treatment of Immature Red Hypertrophic Scars. Journal of Cosmetic Dermatology, 17, 54-60. [Google Scholar] [CrossRef] [PubMed]
[20] Li, H. and Song, T. (2020) 3D Printed Custom Made Pressure Clips for Ear Keloid Treatment after Surgical Excision. American Journal of Otolaryngology, 41, Article ID: 102516. [Google Scholar] [CrossRef] [PubMed]
[21] Lee, Y.I., et al. (2020) Tissue-Remodelling M2 Macrophages Recruit Matrix Metallo-Proteinase-9 for Cryotherapy-Induced Fibrotic Resolution during Keloid Treatment. Acta Dermato-Venereologica, 100, adv00306.
[22] Li, Q.K., Zhang, C.P. and Fu, X.B. (2016) Will Stem Cells Bring Hope to Pathological Skin Scar Treatment? Cytotherapy, 18, 943-956. [Google Scholar] [CrossRef] [PubMed]
[23] 郑杨, 罗赛, 赵芳宁, 崔煜煜, 张茜, 郝立君. 间充质干细胞治疗瘢痕疙瘩机制的最新研究进展[J]. 中国美容整形外科杂志, 2019, 30(12): 762-764+773.
[24] 王其飞, 秦泽莲. 细胞自噬与瘢痕疙瘩的研究进展[J]. 中国微创外科杂志, 2019, 19(11): 1032-1035.
[25] Lee, G., Hunter-Smith, D.J. and Rozen, W.M. (2017) Autologous Fat Grafting in Keloids and Hypertrophic Scars: A Review. Scars, Burns & Healing, 3. [Google Scholar] [CrossRef] [PubMed]
[26] 高振, 武晓莉, 李青峰. 瘢痕治疗现状与进展[J]. 临床外科杂志, 2020, 28(12): 1106-1109.

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