转录因子EB在机体免疫反应中的研究进展
Research Progress of Transcription Factor EB in Immune Response
DOI: 10.12677/ACM.2021.116381, PDF,    国家自然科学基金支持
作者: 余家建, 范德庆*：重庆市涪陵中心医院肝胆外科，重庆
关键词: TFEB；自噬；溶酶体；抗原提呈；TFEB； Autophagy； Lysosome； Antigen Presentation
摘要: MiT/TFE家族包括转录因子EB (Transcription factor EB, TFEB)、TFE3、TFEC和MITF，其中TFEB在调控细胞能量平衡和自噬溶酶体生物发生中发挥主导作用。自噬溶酶体途径是吞噬并清除废旧蛋白及细胞器从而维持机体平衡的重要途径，而越来越多的研究表明自噬溶酶体在调节机体炎症免疫反应中也具有重要作用。TFEB作为自噬溶酶体生物发生的重要调节因子，可通过影响溶酶体的发生从而调控机体炎症免疫反应。新近研究表明，TFEB还能直接通过调控免疫相关基因的转录，从而调控机体免疫反应。我们将通过对TFEB在自噬与炎症反应的作用进行讨论，为进一步研究TFEB在炎症免疫反应中的作用奠定基础。
Abstract: The MiT/TFE family includes transcription factor EB (TFEB), TFE3, TFEC and MITF, among which TFEB plays a leading role in regulating cell energy balance and autophagolysosome biogenesis. The autophagolysosome pathway is an important way for waste proteins and organelles clearing, and more and more studies show that autophagolysosomes also play an important role in regulating the body’s inflammatory immune response. TFEB, as an important regulator of autophagolysosome biogenesis, can regulate the inflammatory immune response of the body by affecting the occurrence of lysosomes. Recent studies have shown that TFEB can also directly regulate the immune response of the body by regulating the transcription of immune-related genes. We are going to discuss the role of TFEB in autophagy and inflammatory response to lay the foundation for further research on the role of TFEB in inflammatory immune response.
文章引用：余家建, 范德庆. 转录因子EB在机体免疫反应中的研究进展[J]. 临床医学进展, 2021, 11(6): 2639-2644. https://doi.org/10.12677/ACM.2021.116381

参考文献

[1] Wang, H., Wang, N., Xu, D., Ma, Q., Chen, Y., Xu, S., et al. (2020) Oxidation of Multiple MiT/TFE Transcription Factors Links Oxidative Stress to Transcriptional Control of Autophagy and Lysosome Biogenesis. Autophagy, 16, 1683-1696. [Google Scholar] [CrossRef] [PubMed]
[2] Ballabio, A. and Bonifacino, J.S. (2020) Lysosomes as Dynamic Regulators of Cell and Organismal Homeostasis. Nature Reviews Molecular Cell Biology, 21, 101-118. [Google Scholar] [CrossRef] [PubMed]
[3] Hipolito, V.E.B., Diaz, J.A., Tandoc, K.V., Oertlin, C., Ristau, J., Chauhan, N., et al. (2019) Enhanced Translation Expands the Endo-Lysosome Size and Promotes Antigen Presentation during Phagocyte Activation. PLoS Biology, 17, e3000535. [Google Scholar] [CrossRef] [PubMed]
[4] Sharrock, J. and Sun, J.C. (2020) Innate Immunological Memory: From plants to Animals. Current Opinion in Immunology, 62, 69-78. [Google Scholar] [CrossRef] [PubMed]
[5] Irazoqui, J.E. (2020) Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation. Trends in Immunology, 41 157-171. [Google Scholar] [CrossRef] [PubMed]
[6] Tan, P., Ye, Y., Mao, J. and He, L. (2019) Autophagy and Immune-Related Diseases. In: Cui, J., Ed., Advances in Experimental Medicine and Biology, Vol. 1209, Springer, Singapore, 167-179. [Google Scholar] [CrossRef] [PubMed]
[7] Levine, B. and Kroemer, G. (2019) Biological Functions of Autophagy Genes: A Disease Perspective. Cell, 176, 11-42. [Google Scholar] [CrossRef] [PubMed]
[8] Kahlenberg, J.M. and Kang, I. (2020) Advances in Disease Mechanisms and Translational Technologies: Clinicopathologic Significance of Inflammasome Activation in Autoimmune Diseases. Arthritis & Rheumatology, 72, 386-395. [Google Scholar] [CrossRef] [PubMed]
[9] Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S.V., Vieira-Saecker, A., et al. (2019) NLRP3 Inflammasome Activation Drives Tau Pathology. Nature, 575, 669-673. [Google Scholar] [CrossRef] [PubMed]
[10] Ceccariglia, S., Cargnoni, A., Silini, A.R. and Parolini, O. (2020) Autophagy: A Potential Key Contributor to the Therapeutic action of Mesenchymal Stem Cells. Autophagy, 16, 28-37. [Google Scholar] [CrossRef] [PubMed]
[11] Nakamura, S., Shigeyama, S., Minami, S., Shima, T., Akayama, S., Matsuda, T., et al. (2020) LC3 Lipidation Is Essential for TFEB Activation during the Lysosomal Damage Response to Kidney Injury. Nature Cell Biology, 22 1252-1263. [Google Scholar] [CrossRef] [PubMed]
[12] Martina, J.A. and Puertollano, R. (2018) Protein Phosphatase 2A Stimulates Activation of TFEB and TFE3 Transcription Factors in Response to Oxidative Stress. The Journal of Biological Chemistry, 293, 12525-12534. [Google Scholar] [CrossRef] 
[13] Rusmini, P., Cortese, K., Crippa, V., Cristofani, R., Cicardi, M.E., Ferrari, V., et al. (2019) Trehalose Induces Autophagy via Lysosomal-Mediated TFEB Activation in Models of Motoneuron Degeneration. Autophagy, 15, 631-651. [Google Scholar] [CrossRef] [PubMed]
[14] Li, P., Gu, M. and Xu, H. (2019) Lysosomal Ion Channels as Decoders of Cellular Signals. Trends in Biochemical Sciences, 44, 110-124. [Google Scholar] [CrossRef] [PubMed]
[15] La Spina, M., Contreras, P.S., Rissone, A., Meena, N.K., Jeong, E. and Martina, J.A. (2020) MiT/TFE Family of Transcription Factors: An Evolutionary Perspective. Frontiers in Cell and Developmental Biology, 8, Article No. 609683. [Google Scholar] [CrossRef] [PubMed]
[16] Guo, H., Pu, M., Tai, Y., Chen, Y., Lu, H., Qiao, J., et al. (2021) Nuclear miR-30b-5p Suppresses TFEB-Mediated Lysosomal Biogenesis and Autophagy. Cell Death and Differentiation, 28, 320-336. [Google Scholar] [CrossRef] [PubMed]
[17] El-Houjeiri, L., Possik, E., Vijayaraghavan, T., Paquette, M., Martina, J.A., Kazan, J.M., et al. (2019) The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance. Cell Reports, 26, 3613-3628.e6. [Google Scholar] [CrossRef] [PubMed]
[18] Dong, X., Yang, Y., Zou, Z., Zhao, Y., Ci, B., Zhong, L., et al. (2021) Sorting Nexin 5 Mediates Virus-Induced Autophagy and Immunity. Nature, 589, 456-461. [Google Scholar] [CrossRef] [PubMed]
[19] Brady, O.A, Martina, J.A. and Puertollano, R. (2018) Emerging Roles for TFEB in the Immune Response and Inflammation. Autophagy, 14, 181-189. [Google Scholar] [CrossRef] [PubMed]
[20] Tiller, G.R. and Garsin, D.A. (2014) Of Worms and Men: HLH-30 and TFEB Regulate Tolerance to Infection. Immunity, 40, 857-858. [Google Scholar] [CrossRef] [PubMed]
[21] Murphy, J.T., Liu, H., Ma, X., Shaver, A., Egan, B.M., Oh, C., et al. (2019) Simple Nutrients Bypass the Requirement for HLH-30 in Coupling Lysosomal Nutrient Sensing to Survival. PLoS Biology, 17, e3000245. [Google Scholar] [CrossRef] [PubMed]
[22] Kumar, S., Jain, A., Choi, S.W., da Silva, G.P.D., Allers, L., Mudd, M.H., et al. (2020) Mammalian Atg8 Proteins and the Autophagy Factor IRGM Control mTOR and TFEB at a Regulatory Node Critical for Responses to Pathogens. Nature Cell Biology, 22, 973-985. [Google Scholar] [CrossRef] [PubMed]
[23] Vural, A., Al-Khodor, S., Cheung, G.Y., Shi, C.S., Srinivasan, L., McQuiston, T.J., et al. (2016) Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection. Journal of Immunology, 196, 846-856. [Google Scholar] [CrossRef] [PubMed]
[24] Torraca, V. and Mostowy, S. (2018) Zebrafish Infection: From Pathogenesis to Cell Biology. Trends in Cell Biology, 28, 143-156. [Google Scholar] [CrossRef] [PubMed]
[25] Yu, L., Zhang, X., Yang, Y., Li, D., Tang, K., Zhao, Z., et al. (2020) Small-Molecule Activation of Lysosomal TRP Channels Ameliorates Duchenne Muscular Dystrophy in Mouse Models. Science Advances, 6, eaaz2736. [Google Scholar] [CrossRef] [PubMed]
[26] Yamamoto, K., Venida, A., Yano, J., Biancur, D.E., Kakiuchi, M., Gupta, S., et al. (2020) Autophagy Promotes Immune Evasion of Pancreatic Cancer by Degrading MHC-I. Nature, 581, 100-105. [Google Scholar] [CrossRef] [PubMed]
[27] Jiang, G.M., Tan, Y., Wang, H., Peng, L., Chen, H.T., Meng, X.J., et al. (2019) The Relationship between Autophagy and the Immune System and Its Applications for Tumor Immunotherapy. Molecular Cancer, 18, Article No. 17. [Google Scholar] [CrossRef] [PubMed]
[28] Bretou, M., Sáez, P.J., Sanséau, D., Maurin, M., Lankar, D., Chabaud, M., et al. (2017) Lysosome Signaling Controls the Migration of Dendritic Cells. Science Immunology, 2, eaak9573. [Google Scholar] [CrossRef] [PubMed]
[29] Bonam, S.R., Wang, F. and Muller, S. (2019) Lysosomes as a Therapeutic Target. Nature Reviews Drug Discovery, 18, 923-948. [Google Scholar] [CrossRef] [PubMed]
[30] Huan, C., Kelly, M.L., Steele, R., Shapira, I., Gottesman, S.R. and Roman, C.A. (2006) Transcription Factors TFE3 and TFEB Are Critical for CD40 Ligand Expression and Thymus-Dependent Humoral Immunity. Nature Immunology, 7, 1082-1091. [Google Scholar] [CrossRef] [PubMed]

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