蠕形螨相关眼部病变的发病机制研究进展
Research Progress on the Pathogenic Mechanism of Demodex-Related Ocular Diseases
DOI: 10.12677/HJO.2021.102008, PDF,   
作者: 高 慧, 黄渝侃*, 陈 华, 李玉芷：华中科技大学同济医学院附属医院协和医院眼科，湖北 武汉
关键词: 蠕形螨；眼表疾病；Demodex； Ocular Surface Disease
摘要: 蠕形螨是体表最常见的寄生虫。流行病学和临床研究发现蠕形螨与睑缘炎、睑板腺功能障碍和角结膜炎等眼表疾病密切相关，但蠕形螨相关眼部病变的发病机制尚不明确。在与人体共生过程中，蠕形螨可对睑板腺及睫毛毛囊结构造成损害，其可能是造成眼表病变的原因。近年，蠕形螨致病机制研究日益受到关注，本文就此领域研究进展进行综述，以期为蠕形螨相关眼病诊疗提供帮助。
Abstract: Demodex was one of the most common parasites in the human body. Demodex has been found to be closely associated with ocular diseases such as blepharitis, meibomian gland dysfunction and keratitis. However, the pathogenesis of demodex-related ocular diseases remains unclear. Demodex can cause damage to the structure of the meibomian glands and lash follicles during the symbiosis with human body, which may be the cause of ocular surface lesions. In recent years, the research on the pathogenesis of demodex has attracted increasing attention. This paper reviews the research progress in this field, with a view to provide help for the diagnosis and treatment of demodex-related ocular diseases.
文章引用：高慧, 黄渝侃, 陈华, 李玉芷. 蠕形螨相关眼部病变的发病机制研究进展[J]. 眼科学, 2021, 10(2): 69-75. https://doi.org/10.12677/HJO.2021.102008

参考文献

[1] Zhang, A.C., Muntz, A., Wang, M., et al. (2020) Ocular Demodex: A Systematic Review of the Clinical Literature. Ophthalmic and Physiological Optics, 40, 389-432.
[Google Scholar] [CrossRef] [PubMed]
[2] Elston, C.A. and Elston, D.M. (2014) Demodex Mites. Clinics in Dermatology, 32, 739-743.
[Google Scholar] [CrossRef] [PubMed]
[3] Zhong, J., Tan, Y., Li, S., et al. (2019) The Prevalence of Demodex folliculorum and Demodex brevis in Cylindrical Dandruff Patients. Journal of Ophthalmology, 2019, Article ID: 8949683.
[Google Scholar] [CrossRef] [PubMed]
[4] Sedzikowska, A., Oseka, M. and Skopinski, P. (2018) The Impact of Age, Sex, Blepharitis, Rosacea and Rheumatoid Arthritis on Demodex Mite Infection. Archives of Medical Science, 14, 353-356.
[Google Scholar] [CrossRef] [PubMed]
[5] Wesolowska, M., Knysz, B., Reich, A., et al. (2014) Prevalence of Demodex spp. in Eyelash Follicles in Different Populations. Archives of Medical Science, 10, 319-324.
[Google Scholar] [CrossRef] [PubMed]
[6] Lee, S.H., Chun, Y.S., Kim, J.H., et al. (2010) The Relationship between Demodex and Ocular Discomfort. Investigative Ophthalmology & Visual Science, 51, 2906-2911.
[Google Scholar] [CrossRef] [PubMed]
[7] Lacey, N., Ní Raghallaigh, S. and Powell, F.C. (2011) Demodex Mites—Commensals, Parasites or Mutualistic Organisms? Dermatology (Basel, Switzerland), 222, 128-130.
[Google Scholar] [CrossRef] [PubMed]
[8] Wu, M., Wang, X., Han, J., et al. (2019) Evaluation of the Ocular Surface Characteristics and Demodex Infestation in Paediatric and adult Blepharokeratoconjunctivitis. BMC Ophthalmology, 19, Article No. 67.
[Google Scholar] [CrossRef] [PubMed]
[9] Aleksandra, S., Maciej, O. and Barbara, G. (2016) Ocular Symptoms Reported by Patients Infested with Demodex Mites. Acta Parasitologica, 61, 808-814.
[Google Scholar] [CrossRef] [PubMed]
[10] Fromstein, S.R., Harthan, J.S., Patel, J. and Opitz, D.L. (2018) Demodex Blepharitis: Clinical Perspectives. Clinical Optometry, 10, 57-63.
[Google Scholar] [CrossRef] 
[11] Hu, L., Zhao, Y., Niu, D., et al. (2019) De Novo Transcriptome Sequencing and Differential Gene Expression Analysis of Two Parasitic Human Demodex Species. Parasitology Research, 118, 3223-3235.
[Google Scholar] [CrossRef] [PubMed]
[12] Liang, L., Ding, X. and Tseng, S.C. (2014) High Prevalence of Demodex brevis Infestation in Chalazia. American Journal of Ophthalmology, 157, 342-348.
[Google Scholar] [CrossRef] [PubMed]
[13] Cheng, A.M., Sheha, H. and Tseng, S.C. (2015) Recent Advances on Ocular Demodex Infestation. Current Opinion in Ophthalmology, 26, 295-300.
[Google Scholar] [CrossRef] 
[14] Liu, J., Sheha, H. and Tseng, S.C. (2010) Pathogenic Role of Demodex Mites in Blepharitis. Current Opinion in Allergy and Clinical Immunology, 10, 505-510.
[Google Scholar] [CrossRef] 
[15] Nicholls, S.G., Oakley, C.L., Tan, A. and Vote, B.J. (2017) Demodex Species in Human Ocular Disease: New Clinicopathological Aspects. International Ophthalmology, 37, 303-312.
[Google Scholar] [CrossRef] [PubMed]
[16] Szkaradkiewicz, A., Chudzicka-Strugała, I., Karpiński, T.M., et al. (2012) Bacillus oleronius and Demodex Mite Infestation in Patients with Chronic Blepharitis. Clinical Microbiology and Infection, 18, 1020-1025.
[Google Scholar] [CrossRef] [PubMed]
[17] Forton, F.M.N. (2020) The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea? Dermatology and Therapy, 10, 1229-1253.
[Google Scholar] [CrossRef] [PubMed]
[18] Georgala, S., Katoulis, A.C., Kylafis, G.D., et al. (2008) Increased Density of Demodex folliculorum and Evidence of Delayed Hypersensitivity Reaction in Subjects with Papulopustular Rosacea. Journal of the European Academy of Dermatology and Venereology, 15, 441-444.
[Google Scholar] [CrossRef] [PubMed]
[19] Luo, X., Li, J., Chen, C., et al. (2017) Ocular Demodicosis as a Potential Cause of Ocular Surface Inflammation. Cornea, 36, S9-S14.
[Google Scholar] [CrossRef] 
[20] Baima, B. and Sticherling, M. (2002) Demodicidosis Revisited. Acta Dermato-Venereologica, 82, No. 1.
[Google Scholar] [CrossRef] [PubMed]
[21] Knop, E., Knop, N., Millar, T., et al. (2011) The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of the Meibomian Gland. Investigative Ophthalmology & Visual Science, 52, 1938-1978.
[Google Scholar] [CrossRef] [PubMed]
[22] Bitton, E. and Aumond, S. (2021) Demodex and Eye Disease: A Review. Clinical and Experimental Optometry, 104, 285-294.
[Google Scholar] [CrossRef] [PubMed]
[23] Kheirkhah, A., Casas, V., Li, W., et al. (2007) Corneal Manifestations of Ocular Demodex Infestation. American Journal of Ophthalmology, 143, 743-749.E1.
[Google Scholar] [CrossRef] [PubMed]
[24] Zhang, X.B., Ding, Y.H. and He, W. (2018) The Association between Demodex Infestation and Ocular Surface Manifestations in Meibomian Gland Dysfunction. International Journal of Ophthalmology, 11, 589-592.
[25] Kim, J.T., Lee, S.H., Chun, Y.S. and Kim, J.C. (2011) Tear Cytokines and Chemokines in Patients with Demodex Blepharitis. Cytokine, 53, 94-99.
[Google Scholar] [CrossRef] [PubMed]
[26] Huang, Y., He, H., Sheha, H. and Tseng, S.C.G. (2013) Ocular Demodicosis as a Risk Factor of Pterygium Recurrence. Ophthalmology, 120, 1341-1347.
[Google Scholar] [CrossRef] [PubMed]
[27] Kheirkhah, A., Blanco, G., Casas, V., et al. (2007) Fluorescein Dye Improves Microscopic Evaluation and Counting of Demodex in Blepharitis with Cylindrical Dandruff. Cornea, 26, 697-700.
[Google Scholar] [CrossRef] 
[28] Cheng, S., Zhang, M., Chen, H., et al. (2019) The Correlation between the Microstructure of Meibomian Glands and Ocular Demodex Infestation: A Retrospective Case-Control Study in a Chinese Population. Medicine (Baltimore), 98, e15595.
[Google Scholar] [CrossRef] 
[29] Tighe, S., Gao, Y.-Y. and Tseng, S.C.G. (2013) Terpinen-4-ol Is the Most Active Ingredient of Tea Tree Oil to Kill Demodex Mites. Translational Vision Science & Technology, 2, 2.
[Google Scholar] [CrossRef] [PubMed]
[30] Hecht, I., Melzer-Golik, A., Sadi, S.N., et al. (2019) Permethrin Cream for the Treatment of Demodex Blepharitis. Cornea, 38, 1513-1518.
[Google Scholar] [CrossRef] 
[31] Filho, P.A.N., Hazarbassanov, R.M., Grisolia, A.B.D., et al. (2011) The Efficacy of Oral Ivermectin for the Treatment of Chronic Blepharitis in Patients Tested Positive for Demodex spp. British Journal of Ophthalmology, 95, 893-895.
[Google Scholar] [CrossRef] [PubMed]
[32] Cheng, S.N., Jiang, F.G., Chen, H., et al. (2019) Intense Pulsed Light Therapy for Patients with Meibomian Gland Dysfunction and Ocular Demodex Infestation. Current Medical Science, 39, 800-809.
[Google Scholar] [CrossRef] [PubMed]
[33] Zhang, X.Z., Song, N. and Gong, L. (2019) Therapeutic Effect of Intense Pulsed Light on Ocular Demodicosis. Current Eye Research, 44, 250-256.
[Google Scholar] [CrossRef] [PubMed]
[34] Murube, J. (2015) Demodex hominis. The Ocular Surface, 13, 181-186.
[Google Scholar] [CrossRef] [PubMed]

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