先天性心脏病相关基因的研究进展
Research Progress of Genes Related to Congenital Heart Disease
DOI: 10.12677/ACM.2021.116410, PDF,   
作者: 盛小花：青海大学研究生院，青海 西宁；李 琳：青海大学附属医院心血管内科，青海 西宁
关键词: 先天性心脏病；基因；Congenital Heart Disease； Gene
摘要: 先天性心脏病(CHD)是一种常见的先天性畸形类疾病，是目前最常见的出生缺陷，也是儿童死亡的重要原因之一。CHD主要是由遗传和环境两大因素所致。目前关于CHD的遗传因素主要是单基因缺陷、多基因缺陷、染色体异常、基因组拷贝数变异等。本文根据现有结果就CHD相关基因突变予以综述，为诊治CHD提供分子生物学新思路。
Abstract: Congenital heart disease (CHD) is a common congenital malformation, which is the most common birth defect and one of the major causes of death in children. Genetic and environmental factors are the main causes of congenital heart disease. Genetic factors mainly include single gene defect, polygene defect, chromosome abnormality, genome copy number variation. In addition to familial aggregation, there are also differences in genetic factors among different regions and ethnic groups. Based on the existing results, this paper reviews genes related to CHD so as to provide a new molecular biological idea for the diagnosis and treatment of CHD.
文章引用：盛小花, 李琳. 先天性心脏病相关基因的研究进展[J]. 临床医学进展, 2021, 11(6): 2825-2829. https://doi.org/10.12677/ACM.2021.116410

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