膜联蛋白A5在围生期疾病中的研究进展
The Research Progress of Annexin A5 in Perinatal Diseases
DOI: 10.12677/ACM.2021.117438, PDF,   
作者: 滕 萌, 潘一丹：大连医科大学，辽宁 大连；于 静, 瓮占平*：青岛市市立医院，山东 青岛
关键词: 膜联蛋白A5；围生期疾病；抗凝；细胞融合；Annexin A5； Perinatal Disease； Anticoagulation； Cell Fusion
摘要: 膜联蛋白A5 (Anx A5)是钙依赖的磷脂结合蛋白家族的一员，其广泛存在于组织细胞中，因为其具有的独特结构而参加多种细胞内、外的抗凝、促凋亡等重要功能。近年来研究发现，膜联蛋白A5在妊娠特发疾病如子痫前期、胎儿生长受限等孕妇的血清及胎盘组织中的表达下降，与多种疾病的发生发展密切相关。现就膜联蛋白A5的生物学功能及与各种妊娠相关疾病的关系进行分析与总结，为围生期相关疾病的预防及治疗提供新思路。
Abstract: Annexin A5 (Anx A5) is a member of the calcium-dependent phospholipid binding protein family, which is widely present in tissues and cells. Because of its unique structure, it participates in a variety of important functions inside and outside the cell, such as anticoagulant and pro-apoptosis. In recent years, a large of number studies have showed that the expression of Annexin A5 in the serum and placental tissues of pregnant women with idiopathic pregnancy-related diseases such as preeclampsia, fetal growth restriction has decreased, which is closely related to the occurrence and development of many diseases. The biological function of Annexin A5 and the relationship with various pregnancy-related diseases are analyzed and summarized, which provides new ideas for the prevention and treatment of perinatal-related diseases.
文章引用：滕萌, 于静, 潘一丹, 瓮占平. 膜联蛋白A5在围生期疾病中的研究进展[J]. 临床医学进展, 2021, 11(7): 3012-3017. https://doi.org/10.12677/ACM.2021.117438

参考文献

[1] Moss, S.E. and Morgan, R.O. (2004) The Annexins. Genome Biology, 5, 1-8. [Google Scholar] [CrossRef] [PubMed]
[2] Gerke, V., Creutz, C.E. and Moss, S.E. (2005) Annexins: Linking Ca2+ Signalling to Membrane Dynamics. Nature Reviews Molecular Cell Biology, 6, 449-461. [Google Scholar] [CrossRef] [PubMed]
[3] Bohn, H. and Kraus, W. (1979) Isolation and Characterization of a New Placenta Specific Protein (PP10) (Author’s Transl). Archives of Gynecology, 227, 125-134. [Google Scholar] [CrossRef] 
[4] Cookson, B.T., Engelhardt, S., Smith, C., et al. (1994) Organization of the Human Annexin V (ANX5) Gene. Genomics, 20, 463-467. [Google Scholar] [CrossRef] [PubMed]
[5] Wu, X.-X., Arslan, A.A., Wein, R., et al. (2006) Analysis of Circulating Annexin A5 Parameters during Pregnancy: Absence of Differences between Women with Recurrent Spontaneous Pregnancy Losses and Controls. American Journal of Obstetrics and Gynecology, 195, 971. [Google Scholar] [CrossRef] [PubMed]
[6] Rand, J.H., Wu, X.X., Quinn, A.S., Chen, P.P., McCrae, K.R., Bovill, E.G., et al. (2003) Human Monoclonal Antiphospholipid Antibodies Disrupt the Annexin A5 Anticoagulant Crystal Shield on Phospholipid Bilayers: Evidence from Atomic Force Microscopy and Functional Assay. The American Journal of Pathology, 163, 1193-1200. [Google Scholar] [CrossRef] 
[7] Shyu, V.B.H., Hsu, C.E., Wen, C.J., et al. (2017) Novel Injury Site Targeted Fusion Protein Comprising Annexin V and Kunitz Inhibitor Domains Ameliorates Ischemia-Reperfusion Injury and Promotes Survival of Ischemic Rat Abdominal Skin Flaps. Annals of Plastic Surgery, 78, S129-S134. [Google Scholar] [CrossRef] 
[8] Bouter, A., Carmeille, R., Gounou, C., Bouvet, F., Degrelle, S.A., Evain-Brion, D. and Brisson, A.R. (2015) Review: Annexin-A5 and Cell Membrane Repair. Placenta, 36, S43-S49. [Google Scholar] [CrossRef] [PubMed]
[9] Carmeille, R., Degrelle, S.A., Plawinski, L., et al. (2015) Annexin-A5 Promotes Membrane Resettling in Human Trophoblasts. Biochimica et Biophysica Acta, 1853, 2033-2044. [Google Scholar] [CrossRef] [PubMed]
[10] Degrelle, S.A., Gerbaud, P., Leconte, L., et al. (2017) Annexin-A5 Organized in 2D-Network at the Plasmalemma Eases Human Trophoblast Fusion. Scientific Reports, 7, Article No. 42173. [Google Scholar] [CrossRef] [PubMed]
[11] Gerke, V. and Moss, S.E. (2002) Annexins: From Structure to Function. Physiological Reviews, 82, 331-371. [Google Scholar] [CrossRef] [PubMed]
[12] Sifakis, S., Soufla, G., Koukoura, O., et al. (2010) Decreased Annexin A5 mRNA Placental Expression in Pregnancies Complicated by Fetal Growth Restriction. Thrombosis Research, 125, 326-331. [Google Scholar] [CrossRef] [PubMed]
[13] Ornaghi, S., Vergani, P., Urban, G., Giardini, V., Moltrasio, F. and Leone, B.E. (2011) Immunohistochemical Expression of Annexin A5 in Preeclamptic Placentas. Placenta, 32, 264-268. [Google Scholar] [CrossRef] [PubMed]
[14] Van Eerden, P., Wu, X.-X., et al. (2007) Annexin A5 Levels in Midtrimester Amniotic Fluid: Association with Intrauterine Growth Restriction. American Journal of Obstetrics and Gynecology, 194, 1371-1376. [Google Scholar] [CrossRef] [PubMed]
[15] De Carolis, S., Moresi, S., Rizzo, F., Monteleone, G., Tabacco, S., Salvi, S., Garufi, C. and Lanzone, A. (2019) Autoimmunity in Obstetrics and Autoimmune Diseases in Pregnancy. Best Practice and Research: Clinical Obstetrics and Gynaecology, 60, 66-76. [Google Scholar] [CrossRef] [PubMed]
[16] Li, X., Chen, L., Liang, X.J., et al. (2012) Annexin A5 Protein Expression Is Associated with the Histological Differentiation of Uterine Cervical Squamous Cell Carcinoma in Patients with an Increased Serum Concentration. Molecular Medicine Reports, 6, 1249-1254. [Google Scholar] [CrossRef] [PubMed]
[17] Avriel, A., Fleischer, S., Friger, M., et al. (2016) Prediction of Antiphospholipid Syndrome Using Annexin A5 Competition Assay in Patients with SLE. Clinical Rheumatology, 35, 2933-2938. [Google Scholar] [CrossRef] [PubMed]
[18] Wang, X., Campos, B., Kaetzel, M.A. and Dedman, J.R. (1999) Annexin V Is Critical in the Maintenance of Murine Placental Integrity. American Journal of Obstetrics & Gynecology, 180, 1008-1016. [Google Scholar] [CrossRef] 
[19] Omar, G., Mohamed, F.I., Sadek, H.A. and Mamdouh, A. (2018) Diagnostic Value of Anti-Annexin A5 Antibodies in Seropositive versus Seronegative Antiphospholipid Syndrome Patients. Egyptian Rheumatologist, 40, 111-116. [Google Scholar] [CrossRef] 
[20] Rand, J.H., Wu, X.X., Andree, H.A.M., Lockwood, C.J., Guller, S., Scher, J. and Harpel, P.C. (1997) Pregnancy Loss in the Antiphospholipid-Antibody Syndrome—A Possible Thrombogenic Mechanism. The New England Journal of Medicine, 337, 154-160. [Google Scholar] [CrossRef] 
[21] Hrycek, A. and Cielik, P. (2012) Annexin A5 and Anti-Annexin Antibodies in Patients with Systemic Lupus Erythematosus. Rheumatology International, 32, 1335-1342. [Google Scholar] [CrossRef] [PubMed]
[22] Wahezi, D.M., Ilowite, N.T., Wu, X.X., et al. (2013) Annexin A5 Anticoagulant Activity in Children with Systemic Lupus Erythematosus and the Association with Antibodies to DOMAIN I of beta2-Glycoprotein I. Lupus, 22, 702-711. [Google Scholar] [CrossRef] [PubMed]
[23] Gathiram, P. and Moodley, J. (2016) Pre-Eclampsia: Its Pathogenesis and Pathophysiolgy. Cardiovascular Journal of Africa, 27, 71-78. [Google Scholar] [CrossRef] 
[24] Shu, F., Sugimura, M., Kanayama, N., et al. (2000) Immunohistochemical Study of Annexin V Expression in Placentae of Preeclampsia. Gynecologic and Obstetric Investigation, 49, 17-23. [Google Scholar] [CrossRef] [PubMed]
[25] Hong, X. and Wang, H.L. (2011) Expression Changes and Clinical Significance of Annexin V in Maternal Blood and Placenta in Patients with Preeclampsia. Chinese Journal of Obstetrics and Gynecology, 46, 88-93.
[26] Rand, J.H., Wu, X.X., et al. (2004) Detection of Antibody Mediated Reduction of Annexin A5 Anticoagulant Activity in Plasnms of Patients with the Antiphospholipid Syndrome. Blood, 104, 2783-2790. [Google Scholar] [CrossRef] [PubMed]

为你推荐