蛋白酪氨酸磷酸酶相互作用蛋白51的研究进展
Protein Tyrosine Phosphatase Interacting Protein 51 Research Progress
DOI: 10.12677/ACM.2021.117444, PDF,   
作者: 于 群:潍坊医学院麻醉学院,山东 潍坊;王海鹏, 陈怀龙, 时 飞*:青岛大学附属青岛市市立医院麻醉科,山东 青岛;张文博:烟台市烟台山医院麻醉科,山东 烟台
关键词: 蛋白酪氨酸磷酸酶相互作用蛋白51MAPK途径细胞凋亡肿瘤线粒体–内质网结构偶联Protein Tyrosine Phosphatase Interacting Protein 51 MAPK Pathway Apoptosis Tumor Mitochondria-Associated Endoplasmic Reticulum Membranes
摘要: 蛋白酪氨酸磷酸酶相互作用蛋白51 (PTPIP51)是一种进化保守的新型线粒体蛋白,在哺乳动物中广泛表达,与多种蛋白结合参与细胞信号通路的传递,是各项生命活动正常进行的基础,多种疾病的发生都与PTPIP51的表达异常有关。本文就PTPIP51的生物学特性、在细胞周期中的作用、与细胞凋亡和自噬、与肿瘤和神经退行性疾病的关系以及在记忆中的作用等研究做一综述。
Abstract: Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is an evolutionarily conserved new type of mitochondrial protein widely expressed in mammals. Binding to multiple proteins to participate in the transmission of cellular signaling pathways is the basis for the normal conduct of various life activities. The occurrence of multiple diseases is all related to the abnormal expression of PTPIP51. This review focuses on the biological characteristics of PTPIP51, its role in the cell cycle, its association with apoptosis and autophagy, with tumor and neurodegenerative diseases, and in memory.
文章引用:于群, 王海鹏, 张文博, 陈怀龙, 时飞. 蛋白酪氨酸磷酸酶相互作用蛋白51的研究进展[J]. 临床医学进展, 2021, 11(7): 3062-3069. https://doi.org/10.12677/ACM.2021.117444

参考文献

[1] Stenzinger, A., Kajosch, T., Tag, C., et al. (2005) The Novel Protein PTPIP51 Exhibits Tissue and Cell-Specific Expression. Histochemistry and Cell Biology, 123, 19-28. [Google Scholar] [CrossRef] [PubMed]
[2] Stenzinger, A., Schreiner, D., Koch, P., et al. (2009) Cell and Molecular Biology of the Novel Protein Tyrosine-Phosphatase-Interacting Protein 51. International Review of Cell and Molecular Biology, 275, 183-246. [Google Scholar] [CrossRef
[3] Brobeil, A., Bobrich, M. and Wimmer, M. (2011) Protein Tyrosine Phosphatase Interacting Protein 51—A Jack of All Trades Protein. Cell and Tissue Research, 344, 189-205. [Google Scholar] [CrossRef] [PubMed]
[4] Schwarzer, R., Laurien, L. and Pasparakis, M. (2020) New Insights into the Regulation of Apoptosis, Necroptosis, and Pyroptosis by Receptor Interacting Protein Kinase 1 and Caspase-8. Current Opinion in Cell Biology, 63, 186-193. [Google Scholar] [CrossRef] [PubMed]
[5] Leano, J.B. and Slep, K.C. (2019) Structures of TOG1 and TOG2 from the Human Microtubule Dynamics Regulator CLASP1. PLoS ONE, 14, e0219823. [Google Scholar] [CrossRef] [PubMed]
[6] Yu, C., Han, W., Shi, T., et al. (2008) PTPIP51, a Novel 14-3-3 Binding Protein, Regulates Cell Morphology and Motility via Raf-ERK Pathway. Cell Signal, 20, 2208-2220. [Google Scholar] [CrossRef] [PubMed]
[7] Brobeil, A., Bobrich, M., Tag, C., et al. (2012) PTPIP51 in Protein Interactions—Regulation and in Situ Interacting Partners. Cell Biochemistry and Biophysics, 63, 211-222. [Google Scholar] [CrossRef] [PubMed]
[8] Hanoun, M., Zhang, D., Mizoguchi, T., et al. (2014) Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche. Cell Stem Cell, 15, 365-375. [Google Scholar] [CrossRef] [PubMed]
[9] Oishi, K., Okano, H. and Sawa, H. (2007) RMD-1, a Novel Microtubule-Associated Protein, Functions in Chromosome Segregation in Caenorhabditis elegans. Cell Biology, 179, 1149-1162. [Google Scholar] [CrossRef] [PubMed]
[10] Benakanakere, M.R., Zhao, J., Finoti, L., et al. (2019) MicroRNA-663 Antagonizes Apoptosis Antagonizing Transcription Factor to Induce Apoptosis in Epithelial Cells. Apoptosis, 24, 108-118. [Google Scholar] [CrossRef] [PubMed]
[11] Lee, Y.S., Kalimuthu, K., Park, Y.S., et al. (2020) BAX-Dependent Mitochondrial Pathway Mediates the Crosstalk between Ferroptosis and Apoptosis. Apoptosis, 25, 625-631. [Google Scholar] [CrossRef] [PubMed]
[12] 肖玉霞. 蛋白酪氨酸磷酸酶相互作用蛋白51的研究进展[J]. 国际口腔医学杂志, 2012, 39(5): 679-682.
[13] Gomez-Suaga, S., Paillusson, R., Stoica, W., et al. (2017) The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy. Current Biology, 27, 371-385. [Google Scholar] [CrossRef] [PubMed]
[14] Qiao, X., Jia, S., Ye, J., et al. (2017) PTPIP51 Regulates Mouse Cardiac Ischemia/Reperfusion through Mediating the Mitochondria-SR Junction. Scientific Reports, 7, Article No. 45379. [Google Scholar] [CrossRef] [PubMed]
[15] Rimessi, A., Pozzato, C., Carparelli, L., et al. (2020) Pharmacological Modulation of Mitochondrial Calcium Uniporter Controls Lung Inflammation in Cystic Fibrosis. Science Advances, 6, eaax9093. [Google Scholar] [CrossRef] [PubMed]
[16] Liu, Z., Zhu, G., Getzenberg, R.H., et al. (2015) The Upregulation of PI3K/Akt and MAP Kinase Pathways Is Associated with Resistance of Microtubule-Targeting Drugs in Prostate Cancer. Journal of Cellular Biochemistry, 116, 1341-1349. [Google Scholar] [CrossRef] [PubMed]
[17] Antolín-Novoa, S., Blanco-Campanario, E., Antón, A., et al. (2015) Adjuvant Regimens with Trastuzumab Administered for Small HER2-Positive Breast Cancer in Routine Clinical Practice. Clinical and Translational Oncology, 17, 862-869. [Google Scholar] [CrossRef] [PubMed]
[18] Moasser, M.M. (2007) The Oncogene HER2: Its Signaling and Transforming Functions and Its Role in Human Cancer Pathogenesis. Oncogene, 26, 6469-6487. [Google Scholar] [CrossRef] [PubMed]
[19] Dietel, E., Brobeil, A. and Gattenlöhner, S. (2018) The Importance of the Right Framework: Mitogen-Activated Protein Kinase Pathway and the Scaffolding Protein PTPIP51. International Journal of Molecular Sciences, 19, 3282. [Google Scholar] [CrossRef] [PubMed]
[20] Dietel, E., Brobeil, A., Tag, C., et al. (2018) Effectiveness of EGFR/HER2-Targeted Drugs Is Influenced by the Downstream Interaction Shifts of PTPIP51 in HER2-Amplified Breast Cancer Cells. Oncogenesis, 7, 64. [Google Scholar] [CrossRef] [PubMed]
[21] Peiró, G., Ortiz-Martínez, F., Gallardo, M.A., et al. (2014) Src, a Potential Target for Overcoming Trastuzumab Resistance in HER2-Positive Breast Carcinoma. British Journal of Cancer, 111, 689-695. [Google Scholar] [CrossRef] [PubMed]
[22] Dietel, E., Brobeil, A., Tag, C., et al. (2020) PTPIP51 Crosslinks the NFκB Signaling and the MAPK Pathway in SKBR3 Cells. Future Science OA, 6, FSO463. [Google Scholar] [CrossRef] [PubMed]
[23] Davis, M.E. (2016) Glioblastoma: Overview of Disease and Treatment. Clinical Journal of Oncology Nursing, 20, S2-S8. [Google Scholar] [CrossRef
[24] Jovčevska, I., Kočevar, N. and Komel, R. (2013) Glioma and Glioblastoma—How Much Do We (Not) Know? Molecular and Clinical Oncology, 1, 935-941. [Google Scholar] [CrossRef] [PubMed]
[25] Verhaak, R.G., Hoadley, K.A., Purdom, E., et al. (2010) Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell, 17, 98-110. [Google Scholar] [CrossRef] [PubMed]
[26] Loew, S., Schmidt, U., Unterberg, A. and Halatsch, M. (2009) The Epidermal Growth Factor Receptor as a Therapeutic Target in Glioblastoma Multiforme and Other Malignant Neoplasms. Anti-Cancer Agents in Medicinal Chemistry, 9, 703-715. [Google Scholar] [CrossRef] [PubMed]
[27] Chan, X.Y., Singh, A., Osman, N., et al. (2017) Role Played by Signalling Pathways in Overcoming BRAF Inhibitor Resistance in Melanoma. International Journal of Molecular Sciences, 18, E1527. [Google Scholar] [CrossRef] [PubMed]
[28] Davis, E.J., Johnson, D.B., Sosman, J.A. and Chandra, S. (2018) Melanoma: What Do All the Mutations Mean? Cancer, 124, 3490-3499. [Google Scholar] [CrossRef] [PubMed]
[29] Amaral, T., Sinnberg, T., Meier, F., et al. (2017) The Mitogen-Activated Protein Kinase Pathway in Melanoma Part I—Activation and Primary Resistance Mechanisms to BRAF Inhibition. European Journal of Cancer, 73, 85-92. [Google Scholar] [CrossRef] [PubMed]
[30] Kantarjian, H., Brien, S., Jabbour, E., et al. (2012) Improved Survival in Chronic Myeloid Leukemia since the Introduction of Imatinib Therapy: A Single-Institution Historical Experience. Blood, 119, 1981-1987. [Google Scholar] [CrossRef] [PubMed]
[31] Brobeil, A., Bobrich, M., Graf, M., et al. (2011) PTPIP51 Is Phosphorylated by Lyn and c-Src Kinases Lacking Dephosphorylation by PTP1B in Acute Myeloid Leukemia. Leukemia Research, 35, 1367-1375. [Google Scholar] [CrossRef] [PubMed]
[32] Koch, P., Stenzinger, A., Viard, M., et al. (2008) The Novel Protein PTPIP51 Is Expressed in Human Keratinocyte Carcinomas and Their Surrounding Stroma. Journal of Cellular and Molecular Medicine, 12, 2083-2095. [Google Scholar] [CrossRef] [PubMed]
[33] Koch, P., Viard, M., Stenzinger, A., et al. (2009) Expression Profile of PTPIP51 in Mouse Brain. The Journal of Comparative Neurology, 517, 892-905. [Google Scholar] [CrossRef] [PubMed]
[34] Brobeil, A., Viard, M., Petri, M.K., et al. (2015) Memory and PTPIP51-A New Protein in Hippocampus and Cerebellum. Molecular and Cellular Neuroscience, 64, 61-73. [Google Scholar] [CrossRef] [PubMed]
[35] Appel-Cresswell, S., Vilarino-Guell, C., Encarnacion, M., et al. (2013) Alpha-Synuclein p.H50Q, a Novel Pathogenic Mutation for Parkinson’s Disease. Movement Disorders, 28, 811-813. [Google Scholar] [CrossRef] [PubMed]
[36] Gómez-Suaga, P., Pérez-Nievas, B.G., Glennon, E.B., et al. (2019) The VAPB-PTPIP51 Endoplasmic Reticulum-Mitochondria Tethering Proteins Are Present in Neuronal Synapses and Regulate Synaptic Activity. Acta Neuropathologica Communications, 7, 35. [Google Scholar] [CrossRef] [PubMed]
[37] Paillusson, S., Gomez-Suaga, P., Stoica, R., et al. (2017) α-Synuclein Binds to the ER-Mitochondria Tethering Protein VAPB to Disrupt Ca2+ Homeostasis and Mitochondrial ATP Production. Acta Neuropathologica, 134, 129-149. [Google Scholar] [CrossRef] [PubMed]
[38] Oba, T., Saito, T., Asada, A., et al. (2020) Microtubule Affinity-Regulating Kinase 4 with an Alzheimer’s Disease-Related Mutation Promotes Tau Accumulation and Exacerbates Neurodegeneration. Journal of Biological Chemistry, 295, 17138-17147. [Google Scholar] [CrossRef
[39] Schreiner, B., Hedskog, L., Wiehager, B., et al. (2015) Amyloid-β Peptides Are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes. Journal of Alzheimer’s Disease, 43, 369-374. [Google Scholar] [CrossRef
[40] Lau, D.H.W., Paillusson, S., Hartopp, N., et al. (2020) Disruption of Endoplasmic Reticulum-Mitochondria Tethering Proteins in Post-Mortem Alzheimer’s Disease Brain. Neurobiology of Disease, 14, Article ID: 105020. [Google Scholar] [CrossRef] [PubMed]
[41] Puri, R., Cheng, X.T., Lin, M.Y., et al. (2019) Mul1 Restrains Parkin-Mediated Mitophagy in Mature Neurons by Maintaining ER-Mitochondrial Contacts. Nature Communications, 10, 3645. [Google Scholar] [CrossRef] [PubMed]