脑梗死与肠道菌群关系的研究进展
Research Progress on the Relationship between Cerebral Infarction and Intestinal Microbiome
DOI: 10.12677/ACM.2021.117447, PDF,   
作者: 杨 潇, 刘云财, 张亚军:昆明医科大学,云南 昆明;尹凤琼*:昆明医科大学第二附属医院特需病房,云南 昆明
关键词: 脑梗死肠道菌群糖尿病高脂血症高血压Cerebral Infarction Intestinal Microbiome Diabetes Hyperlipidemia Hypertension
摘要: 肠道菌群在脑梗死(cerebral infraction, CI)中具有重要作用,与糖尿病、高脂血症、高血压、脑梗死的发生发展密切相关。胃肠道被称为第二大脑,其神经元数量仅次于中枢神经系统,胃肠道中微生物数量超过1014,是人类细胞数量的10倍,在人体健康中起着重要作用。本文将综述肠道菌群在糖尿病、高脂血症、高血压、脑梗死的发生、发展中的作用和机制,以及在脑梗死防治方面的潜在价值,为脑梗死的防治提供新思路。
Abstract: Intestinal microbiome plays an important role in cerebral infarction, and is closely related to the occurrence and development of diabetes, hyperlipidemia, hypertension and cerebral infarction. Gastrointestinal tract is known as the second brain, the number of neurons is second only to the central nervous system, the number of intestinal microbiome is more than 1014, which is 10 times the number of human cells, and plays an important role in human health. This article will review the role and mechanism of intestinal microbiome in the occurrence and development of diabetes, hyperlipidemia, hypertension and cerebral infarction, as well as its potential value in the prevention and treatment of cerebral infarction, so as to provide new ideas for the prevention and treatment of cerebral infarction.
文章引用:杨潇, 刘云财, 张亚军, 尹凤琼. 脑梗死与肠道菌群关系的研究进展[J]. 临床医学进展, 2021, 11(7): 3083-3090. https://doi.org/10.12677/ACM.2021.117447

参考文献

[1] Wang, W., Jiang, B., Sun, H., Ru, X., Sun, D., Wang, L., et al. (2017) Prevalence, Incidence, and Mortality of Stroke in China. Circulation, 135, 759-771. [Google Scholar] [CrossRef
[2] Ning, X., Sun, J., Jiang, R., Lu, H., Bai, L., Shi, M., et al. (2017) Increased Stroke Burdens Among the Low-Income Young and Middle Aged in Rural China. Stroke, 48, 77-83. [Google Scholar] [CrossRef] [PubMed]
[3] Bäckhed, F., Ley, R.E., Sonnenburg, J.L., Peterson, D.A. and Gordon, J.I. (2005) Host-Bacterial Mutualism in the Human Intestine. Science, 307, 1915-1920. [Google Scholar] [CrossRef] [PubMed]
[4] Barko, P.C., Mcmichael, M.A., Swanson, K.S. and Williams, D. (2018) The Gastrointestinal Microbiome: A Review. Journal of Veterinary Internal Medicine, 32, 9-25. [Google Scholar] [CrossRef] [PubMed]
[5] Lynch, S.V. and Pedersen, O. (2016) The Human Intestinal Microbiome in Health and Disease. The New England Journal of Medicine, 375, 2369-2379. [Google Scholar] [CrossRef] [PubMed]
[6] Reimann, F. and Gribble, F.M. (2016) Mechanisms Underlying Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Secretion. Journal of Diabetes Investigation, 7, 13-19. [Google Scholar] [CrossRef] [PubMed]
[7] Grasset, E., Puel, A., Charpentier, J., Collet, X., Christensen, J.E., Tercé, F., et al. (2017) A Specific Gut Microbiota Dysbiosis of Type 2 Diabetic Mice Induces GLP-1 Resistance through an Enteric NO-Dependent and Gut-Brain Axis Mechanism. Cell Metabolism, 26, 278. [Google Scholar] [CrossRef] [PubMed]
[8] Ankit, G., Jelinek, H.F. and Hayder, A.-A. (2017) Glucagon Like Peptide-1 and Its Receptor Agonists: Their Roles in Management of Type 2 Diabetes Mellitus. Diabetes & Metabolic Syndrome, 11, 225-230. [Google Scholar] [CrossRef] [PubMed]
[9] Færch, K., Torekov, S.S., Vistisen, D., Johansen, N.B., Witte, D.R., Jonsson, A., et al. (2015) GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study. Diabetes, 64, 2513-2525. [Google Scholar] [CrossRef] [PubMed]
[10] Psichas, A., Sleeth, M.L., Murphy, K.G., Brooks, L., Bewick, G.A., Hanyaloglu, A.C., et al. (2015) The Short Chain Fatty Acid Propionate Stimulates GLP-1 and PYY Secretion via Free Fatty Acid Receptor 2 in Rodents. International Journal of Obesity, 39, 424-429. [Google Scholar] [CrossRef] [PubMed]
[11] Zhao, L., Zhang, F., Ding, X., Wu, G., Lam, Y.Y., Wang, X., et al. (2018) Gut Bacteria Selectively Promoted by Dietary Fibers Alleviate Type 2 Diabetes. Science, 359, 1151-1156. [Google Scholar] [CrossRef] [PubMed]
[12] Mano, F., Ikeda, K., Joo, E., Fujita, Y., Yamane, S., Harada, N., et al. (2018) The Effect of White Rice and White Bread as Staple Foods on Gut Microbiota and Host Metabolism. Nutrients, 10, Article No. 1323. [Google Scholar] [CrossRef] [PubMed]
[13] Annika, W., Petia, K.-D., Marcus, S., Bäckhed, F. and Marschall, H.-U. (2017) Crosstalk between Bile Acids and Gut Microbiota and Its Impact on Farnesoid X Receptor Signalling. Digestive Diseases, 35, 246-250. [Google Scholar] [CrossRef] [PubMed]
[14] Brønden, A., Albér, A., Rohde, U., Gasbjerg, L.S., Rehfeld, J.F., Holst, J.J., et al. (2018) The Bile Acid-Sequestering Resin Sevelamer Eliminates the Acute GLP-1 Stimulatory Effect of Endogenously Released Bile Acids in Patients with Type 2 Diabetes. Diabetes, Obesity & Metabolism, 20, 362-369. [Google Scholar] [CrossRef] [PubMed]
[15] Just, S., Mondot, S., Ecker, J., Wegner, K., Rath, E., Gau, L., et al. (2018) The Gut Microbiota Drives the Impact of Bile Acids and Fat Source in Diet on Mouse Metabolism. Microbiome, 6, Article No. 134. [Google Scholar] [CrossRef] [PubMed]
[16] Yanyun, G., Xiaokai, W., Junhua, L., Zhang, Y., Zhong, H., Liu, R., et al. (2017) Analyses of Gut Microbiota and Plasma Bile Acids Enable Stratification of Patients for Antidiabetic Treatment. Nature Communications, 8, Article No. 1785. [Google Scholar] [CrossRef] [PubMed]
[17] Rong, B., Xia, T., Zhang, T., Feng, R., Huang, H., Wu, Q., et al. (2019) Gut Microbiota: A Potential Manipulator for Host Adipose Tissue and Energy Metabolism. The Journal of Nutritional Biochemistry, 64, 206-217. [Google Scholar] [CrossRef] [PubMed]
[18] Nicolucci, A.C., Hume, M.P., Martínez, I., Mayengbam, S., Walter, J. and Reimer, R.A. (2017) Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or with Obesity. Gastroenterology, 153, 711-722. [Google Scholar] [CrossRef] [PubMed]
[19] Ramos-Molina, B., Sánchez-Alcoholado, L., Cabrera-Mulero, A., Lopez-Dominguez, R., Carmona-Saez, P., Garcia-Fuentes, E., et al. (2019) Gut Microbiota Composition Is Associated with the Global DNA Methylation Pattern in Obesity. Frontiers in Genetics, 10, Article No. 613. [Google Scholar] [CrossRef] [PubMed]
[20] Liu, R., Hong, J., Xu, X., Feng, Q., Zhang, D., Gu, Y., et al. (2017) Gut Microbiome and Serum Metabolome Alterations in Obesity and after Weight-Loss Intervention. Nature Medicine, 23, 859-868. [Google Scholar] [CrossRef] [PubMed]
[21] Li, J., Zhao, F., Wang, Y., Chen, J., Tao, J., Tian, G., et al. (2017) Gut Microbiota Dysbiosis Contributes to the Development of Hypertension. Microbiome, 5, Article No. 14. [Google Scholar] [CrossRef] [PubMed]
[22] Adnan, S., Nelson, J.W., Ajami, N.J., Venna, V.R., Petrosino, J.F., Bryan Jr., R.M., et al. (2017) Alterations in the Gut Microbiota Can Elicit Hypertension in Rats. Physiological Genomics, 49, 96-104. [Google Scholar] [CrossRef] [PubMed]
[23] Xie, D., Zhang, M., Wang, B., Lin, H., Wu, E., Zhao, H., et al. (2019) Differential Analysis of Hypertension-Associated Intestinal Microbiota. International Journal of Medical Sciences, 16, 872-881. [Google Scholar] [CrossRef] [PubMed]
[24] Liu, B., Zhang, Y., Wang, R., An, Y., Gao, W., Bai, L., et al. (2018) Western Diet Feeding Influences Gut Microbiota Profiles in apoE Knockout Mice. Lipids in Health and Disease, 17, Article No. 159. [Google Scholar] [CrossRef] [PubMed]
[25] Poppleton, D.I., Duchateau, M., Hourdel, V., Matondo, M., Flechsler, J., Klingl, A., et al. (2017) Outer Membrane Proteome of Veillonella parvula: A Diderm Firmicute of the Human Microbiome. Frontiers in Microbiology, 8, Article No. 1215. [Google Scholar] [CrossRef] [PubMed]
[26] Romano, K.A., Vivas, E.I., Amador-Noguez, D. and Rey, F.E. (2015) Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine-N-Oxide. mBio, 6, e02481. [Google Scholar] [CrossRef
[27] Chen, X., D’Souza, R. and Hong, S.-T. (2013) The Role of Gut Microbiota in the Gut-Brain Axis: Current Challenges and Perspectives. Protein & Cell, 4, 403-414. [Google Scholar] [CrossRef] [PubMed]
[28] Zhu, W., Buffa, J.A., Wang, Z., Warrier, M., Schugar, R., Shih, D.M., et al. (2018) Flavin Monooxygenase 3, the Host Hepatic Enzyme in the Metaorganismal Trimethylamine N-Oxide-Generating Pathway, Modulates Platelet Responsiveness and Thrombosis Risk. Journal of Thrombosis and Haemostasis, 16, 1857-1872. [Google Scholar] [CrossRef] [PubMed]
[29] Nie, J., Xie, L., Zhao, B.X., Li, Y., Qiu, B., Zhu, F., et al. (2018) Serum Trimethylamine N-Oxide Concentration Is Positively Associated with First Stroke in Hypertensive Patients. Stroke, 49, 2021-2028. [Google Scholar] [CrossRef] [PubMed]
[30] Wang, Z., Klipfell, E., Bennett, B.J., Koeth, R., Levison, B.S., DuGar, B., et al. (2011) Gut Flora Metabolism of Phosphatidylcholine Promotes Cardiovascular Disease. Nature, 472, 57-63. [Google Scholar] [CrossRef] [PubMed]
[31] Koeth, R.A., Levison, B.S., Culley, M.K., Buffa, J.A., Wang, Z., Gregory, J.C., et al. (2014) γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L-Carnitine to TMAO. Cell Metabolism, 20, 799-812. [Google Scholar] [CrossRef] [PubMed]
[32] Senthong, V., Li, X.S., Hudec, T., Coughlin, J., Wu, Y., Levison, B., et al. (2016) Plasma Trimethylamine N-Oxide, a Gut Microbe-Generated Phosphatidylcholine Metabolite, Is Associated with Atherosclerotic Burden. Journal of the American College of Cardiology, 67, 2620-2628. [Google Scholar] [CrossRef] [PubMed]
[33] Tang, W.H., Wang, Z. and Levison, B.S. (2013) Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. Journal of Vascular Surgery, 58, 549. [Google Scholar] [CrossRef
[34] Singh, V., Sadler, R., Heindl, S., Llovera, G., Roth, S., Benakis, C., et al. (2018) The Gut Microbiome primes a Cerebroprotective Immune Response after Stroke. Journal of Cerebral Blood Flow & Metabolism, 38, 1293-1298. [Google Scholar] [CrossRef
[35] Yin, J., Liao, S.X., He, Y., Wang, S., Xia, G.H., Liu, F.T., et al. (2015) Dysbiosis of Gut Microbiota with Reduced Trimethylamine-N-Oxide Level in Patients with Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack. Journal of the American Heart Association, 4, e002699. [Google Scholar] [CrossRef
[36] Spychala, M.S., Venna, V.R., Jandzinski, M., Doran, S.J., Durgan, D.J., Ganesh, B.P., et al. (2018) Age-Related Changes in the Gut Microbiota Influence Systemic inflammation and stroke outcome. Annals of Neurology, 84, 23-36. [Google Scholar] [CrossRef] [PubMed]
[37] Vikramjeet, S., Stefan, R., Gemma, L., Sadler, R., Garzetti, D., Stecher, B., et al. (2016) Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke. The Journal of Neuroscienc, 36, 7428-7440. [Google Scholar] [CrossRef
[38] Sadler, R. and Liesz, A. (2020). Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms. Journal of Neuroscience, 40, 1162-1173.[CrossRef
[39] Koh, A., Vadder, F.D., Kovatcheva-Datchary, P. and Bäckhe, F. (2016) From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Cell, 165, 1332-1345. [Google Scholar] [CrossRef] [PubMed]
[40] Chen, R., Xu, Y., Wu, P., Zhou, H., Lasanajak, Y., Fang, Y., et al. (2019) Transplantation of Fecal Microbiota Rich in Short Chain Fatty Acids and Butyric Acid Treat Cerebral Ischemic Stroke by Regulating Gut Microbiota. Pharmacological Research, 148, Article ID: 104403. [Google Scholar] [CrossRef] [PubMed]
[41] 胡诗浩, 杨旭萍, 刘佩芳, 黄寅. 脑卒中并发应激性溃疡的研究进展[J]. 中国医药科学, 2019, 9(16): 47-50+135.
[42] Li, B., Lee, C., Filler, T., Hock, A., Wu, R.Y., Li, Q., et al. (2017) Inhibition of Corticotropin-Releasing Hormone Receptor 1 and Activation of Receptor 2 Protect against Colonic Injury and Promote Epithelium Repair. Scientific Reports, 7, Article No. 46616. [Google Scholar] [CrossRef] [PubMed]
[43] Stanley, D., Mason, L.J., Mackin, K.E., Srikhanta, Y.N, Lyras, D., Prakash, M.D, et al. (2016) Translocation and Dissemination of Commensal Bacteria in Post-Stroke Infection. Nature Medicine, 22, 1277-1284. [Google Scholar] [CrossRef] [PubMed]