伴纤维蛋白原异常的IgA-λ型多发性骨髓瘤1例并文献复习

IgA-λ Multiple Myeloma with Abnormal Fibrigon: A Case Report and Literature Review

摘要: 多发性骨髓瘤是浆细胞恶性克隆性疾病，临床表现多样，少数患者存在出血倾向，以鼻出血和牙龈出血多见，本例患者为中老年女性，首发鼻出血及皮肤出血，测纤维蛋白原明显减低，骨穿见成熟红细胞呈明显缗钱状排列，原幼浆细胞占ANC 54.5%，免疫球蛋白(血)：IgA 87.70 g/L，λ轻链23.70 g/L。诊断：多发性骨髓瘤(IgA-λ型)。

Abstract: Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells with various clinical manifestations. A few patients have bleeding tendency, especially nosebleeds and gingival bleeding. This patient is a middle-aged and old woman, with epistaxis and skin bleeding as the first manifestations. The fibrinogen is obviously reduced, and the mature red blood cells are obviously arranged in a money-like way after bone penetration. The protoplasmic cells account for 54.5% of ANC, and immunoglobulin (blood): IgA 87.70 g/L, λ 23.70 g/L. Diagnosis: Multiple myeloma (IgA-λ type).