硫化氢对内皮细胞分泌凝血物质影响的研究进展
Research Progress on the Effect of Hydrogen Sulfide on the Secretion of Clotting Substances in Endothelial Cells
DOI: 10.12677/ACM.2021.117457, PDF,    国家自然科学基金支持
作者: 董国赟：青海大学研究生院，青海 西宁；王献珍, 李 毅*：青海大学附属医院，青海 西宁
关键词: 内皮细胞；硫化氢；凝血物质；Endothelial Cells； Hydrogen Sulfide； Coagulation Material
摘要: 血管内皮细胞属于单层扁平上皮，主要位于心、血管和淋巴管内表面，在机体凝血系统方面发挥重要作用。内皮细胞受到损伤，对判断疾病进展及预后有一定指导意义。硫化氢作为第3种气体信号分子，能激活内皮细胞ATP敏感钾通道，舒张血管、抑制内皮细胞与白细胞间的黏附、直接或间接降低内皮细胞氧化应激状态，从而降低炎症水平，维持血管内皮细胞功能，减轻内皮细胞损伤后的血管重构，进而维护器官功能改善疾病预后。本文就硫化氢对血管内皮细胞凝血功能影响的研究进展作一综述。
Abstract: Vascular endothelial cells belong to a single layer of flat epithelium, mainly located on the inner surface of the heart, blood vessels and lymphatics, and play an important role in the body’s blood coagulation system. The injury of endothelial cells has a certain guiding significance in judging the progression and prognosis of diseases. Hydrogen sulfide as the third kind of gas signal molecule, it can activate endothelial cell ATP sensitive potassium channels, diastolic blood vessels, inhibit the adhesion between endothelial cells and white blood cells, endothelial cells directly and indirectly reduce the oxidative stress status, thus reducing inflammation levels, maintain vascular endothelial cell function, reduce the endothelial cells of vascular remodeling after injury, and maintain organ function improving the prognosis of disease. This article reviews the research progress on the effect of hydrogen sulfide on the coagulation function of vascular endothelial cells.
文章引用：董国赟, 王献珍, 李毅. 硫化氢对内皮细胞分泌凝血物质影响的研究进展[J]. 临床医学进展, 2021, 11(7): 3152-3157. https://doi.org/10.12677/ACM.2021.117457

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