Sema 3A对骨重塑影响机制的研究进展
Research Progress on the Mechanism of the Effect of Sema 3A on Bone Remodeling
摘要: 骨骼是一个新陈代谢活跃的器官，在人的一生中不断重塑。骨重塑是成骨细胞和破骨细胞在成人生长过程中以及骨折等损伤后对骨骼进行重塑和替代的动态、连续过程。骨重塑受多种因素影响，如各种激素、细胞因子、趋化因子、生物机械刺激等。Sema 3A属于Semaphorins家族中的一员，主要通过调节骨髓间充质干细胞、脂肪间充质干细胞、成骨细胞、破骨细胞、感觉神经等多种途径来影响骨重塑。该综述重点总结并介绍Sema 3A对骨重塑影响机制研究的最新进展，以了解Sema 3A在骨骼系统中的作用。
Abstract: Bone is an organ with active metabolism, which is constantly reshaped throughout a person’s life. Bone remodeling is a dynamic and continuous process of bone remodeling and substitution of osteoblasts and osteoclasts during adult growth and after fracture and other injuries. Bone remodeling is affected by many factors, such as various hormones, cytokines, chemokines, biomechanical stimulation and so on. Sema 3A is a member of the Semaphorins family, mainly through the regulation of bone marrow mesenchymal stem cells, adipose mesenchymal stem cells, osteoblasts, osteoclasts, sensory nerves and other ways to affect bone remodeling. This review focuses on summarizing and introducing the latest progress in the research on the mechanism of the effect of Sema 3A on bone remodeling in order to understand the role of Sema 3A in the skeletal system.
文章引用：蔡丹霞, 罗朋立. Sema 3A对骨重塑影响机制的研究进展[J]. 临床医学进展, 2021, 11(7): 3301-3307. https://doi.org/10.12677/ACM.2021.117480

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