NGAL在糖尿病肾病临床诊断中的作用
The Effect of Neutrophil Gelatinase-Associated Lipocalin in the Clinical Diagnosis of Diabetic Kidney Disease
摘要: 糖尿病肾病是糖尿病最常见的严重微血管并发症之一，是DM患者发病率和死亡率增加的原因之一，已经超越原发性肾小球疾病，成为慢性肾脏病的首位病因。目前，DKD最常用的临床指标是尿白蛋白排泄率(AER)。然而在一些患者中尚未出现微量白蛋白尿时已经存在肾小管损伤，这一定程度上增加了糖尿病肾病疾病进展的风险。近年来，研究发现肾小管损伤标志物如中性粒细胞相关脂蛋白(NGAL)、肾损伤分子-1 (Kim-1)、肝脂肪酸结合蛋白(L-FABP)等有望成为糖尿病肾病临床诊断的潜在生物标记物。本文就NGAL在临床诊断DKD的作用进行综述，为临床诊断DKD提供新的依据。
Abstract: Diabetic kidney disease is one of the most common serious microvascular complications of diabetes and one of the reasons for the increase of morbidity and mortality in patients with DM. It has surpassed primary glomerular disease and become the first cause of chronic kidney disease. At present, the most commonly used clinical indicator of DKD is urinary albumin excretion rate (AER). However, renal tubular damage already exists in some patients without microalbuminuria, which increases the risk of progression of diabetic nephropathy to some extent. In recent years, it has been found that renal tubular injury markers such as Neutrophil gelatinase-associated lipocalin (NGAL), renal injury molecule-1 (Kim-1) and liver fatty acid binding protein (L-FABP) are expected to be potential biomarkers for clinical diagnosis of diabetic nephropathy. This article reviews the role of NGAL in clinical diagnosis of DKD, in order to provide a new basis for clinical diagnosis of DKD.
文章引用：巩艳, 杨小娟. NGAL在糖尿病肾病临床诊断中的作用[J]. 临床医学进展, 2021, 11(7): 3328-3332. https://doi.org/10.12677/ACM.2021.117483

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