长链脂肪醇氯甲酸酯的合成

The Synthesis of Long Chain Alkyl Chloroformate

摘要: 在5℃~10℃下，以石油醚为溶剂、吡啶为缚酸剂，通过长链脂肪醇与三光气反应，制备得到长链脂肪醇氯甲酸酯，收率达到80%以上，含量超过95%。以氯甲酸十二醇酯为例，正十二醇投料放大到41.1 g，氯甲酸十二醇酯收率和含量分别达到89.5%和98.5%，吡啶回收率达到88.1%，该工艺操作简单、安全，具有良好的应用前景。

Abstract: With petroleum ether as solvent and pyridine as acid binding agent, a series of chloroformic esters of long-chain fatty alcohols were synthesized by the reaction of long chain fatty alcohol with triphosgene at 5˚C~10˚C. The yields of chloroformates were over 80% and the content was over 95%. Taking dodecanol chloroformate as an example, the yield and content of dodecanol chloroformate were up to 89.5% and 98.5% respectively when the dosage of n-dodecanol is 41.1g, and the recovery of pyridine reaches 88.1%. The process is simple, safe and has a good application prospect.