WNT信号在胶质母细胞瘤中的作用研究
Study on the Role of WNT Signal in Glioblastoma
DOI: 10.12677/ACM.2021.118488, PDF,    科研立项经费支持
作者: 林圣武, 朱雨峰:青海大学研究生院,青海 西宁;金小青, 卢忠胜*:青海省人民医院神经外科,青海 西宁
关键词: 胶质母细胞瘤WNT信号靶向治疗Glioblastoma WNT Signaling Targeted Therapy
摘要: 胶质母细胞瘤(GBM)是常见的原发性中枢神经系统恶性肿瘤,该肿瘤具有侵袭性强、增殖快、耐药性强及伴有大量血管生成等特点,给临床治疗带来了巨大挑战。因此,需要我们迫切地参透GBM的发病机制,以实现治疗上的突破。近年来,随着对WNT蛋白家族研究的深入,WNT信号在GBM中的发病机制和肿瘤侵袭性生长及靶向治疗方面受到越来越多的关注,本文将在上述几个方面展开综述。
Abstract: Glioblastoma (GBM) is a common malignant tumor of primary central nervous system and the tumor is aggressive, quick breeding, its resistance is strong, and accompanied by a large number of angiogenesis and other characteristics, to clinical therapy, it brings the huge challenge. Obviously, it is urgent to understand the pathogenesis of GBM in order to achieve a breakthrough in treatment. In recent years, with the in-depth study of the WNT protein family, more and more attention has been paid to the pathogenesis of WNT signaling in glioblastoma, tumor invasive growth and targeted therapy. This paper will review the above aspects.
文章引用:林圣武, 朱雨峰, 金小青, 卢忠胜. WNT信号在胶质母细胞瘤中的作用研究[J]. 临床医学进展, 2021, 11(8): 3364-3372. https://doi.org/10.12677/ACM.2021.118488

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