儿童传染性单核细胞增多症研究进展
Research Progress of Infectious Mononucleosis in Children
DOI: 10.12677/ACM.2021.118492, PDF,   
作者: 樊锦茹*, 贾鲲鹏#：延安大学附属医院儿科，陕西 延安
关键词: EB病毒；传染性单核细胞增多症；儿童；Epstein Barr Virus； Infectious Mononucleosis； Children
摘要: 传染性单核细胞增多症(IM)绝大多数是由EB病毒感染引起的，此外巨细胞病毒、人类疱疹病毒6型、腺病毒等也可能是病原，主要侵犯儿童和青少年，临床表现多样，易与其他多种病原体混合感染。本文主要探讨IM的发病机制，总结近年来该病诊断方法与临床治疗方法的研究进展。
Abstract: Infectious mononucleosis (IM) is mostly caused by Epstein Barr virus infection. In addition, cytomegalovirus, human herpesvirus type 6, adenovirus, etc. may also be the pathogens, mainly affecting children and adolescents. The clinical manifestations are diverse, and it is easy to mix with other kinds of pathogens. This paper mainly discusses the pathogenesis of IM, and summarizes the research progress in the diagnosis and clinical treatment of IM in recent years.
文章引用：樊锦茹, 贾鲲鹏. 儿童传染性单核细胞增多症研究进展[J]. 临床医学进展, 2021, 11(8): 3392-3397. https://doi.org/10.12677/ACM.2021.118492

参考文献

[1] 夏玉雪, 方峻. EB病毒与传染性单核细胞增多症的研究进展[J]. 临床内科杂志, 2019, 36(6): 371-374.
[2] 洪淑君, 潘静, 倪文泉, 陈冶, 潘家华, 陈名武. 巨细胞病毒致儿童传染性单核细胞增多综合征81例临床分析[J]. 中华全科医学, 2016, 14(10): 1686-1688.
[3] 郭睿, 李奇玉. 儿童传染性单核细胞增多症的诊断与治疗进展[J]. 中国临床实用医学, 2019, 10(2): 78-80.
[4] 张军华, 田兴德. EB病毒逃避宿主免疫的机制[J]. 医学综述, 2015, 21(3): 417-420.
[5] Wang, L.W., Wang, Z., Ersing, I., Nobre, L., Guo, R., Jiang, S., Trudeau, S., Zhao, B., Weekes, M.P. and Gewurz, B.E. (2019) Epstein-Barr Virus Subverts Mevalonate and Fatty Acid Pathways to Promote Infected B-Cell Proliferation and Survival. PLOS Pathogens, 15, e1008-030. [Google Scholar] [CrossRef] [PubMed]
[6] 韩红满, 李四强. 传染性单核细胞增多症相关免疫学研究进展[J]. 医学综述, 2020, 26(3): 443-447.
[7] Dunmire, S.K., Hogquist, K.A. and Balfour, H.H. (2015) Infectious Mononucleosis. Current Topics in Microbiology and Immunology, 390, 211-240. [Google Scholar] [CrossRef] [PubMed]
[8] 吕洁, 金莲花, 孙景辉, 朴金花. 儿童传染性单核细胞增多症临床特点与发病年龄的关系: 附312例分析[J]. 临床儿科杂志, 2011, 29(6): 518-521.
[9] Fugl, A. and Andersen, C.L. (2019) Epstein-Barr Virus and Its Association with Disease—A Review of Relevance to General Practice. BMC Family Practice, 20, 62. [Google Scholar] [CrossRef] [PubMed]
[10] Huang, Y., Wei, C., Zheng, K. and Zhao, D. (2013) The Impact of Serological Features in Chinese Children with Primary or Past Epstein-Barr Virus Infections. Virology Journal, 10, 55. [Google Scholar] [CrossRef] 
[11] Jiang, S.Y., Yang, J.W., Shao, J.B., Liao, X.L., Lu, Z.H. and Jiang, H. (2016) Real-Time Polymerase Chain Reaction for Diagnosing Infectious Mononucleosis in Pediatric Patients: A Systematic Review and Meta-Analysis. Journal of Medical Virology, 88, 871-876. [Google Scholar] [CrossRef] [PubMed]
[12] Rajadurai, P., Umapati, P., Robert, S., Kathryn, F. and Nancy, R.T. (1995) Clonal Proliferations of Cells Infected with Epstein-Barr Virus in Preinvasive Lesions Related to Nasopharyngeal Carcinoma. The New England Journal of Medicine, 333, 693-698. [Google Scholar] [CrossRef] 
[13] 谢正德, 张蕊, 俞蕙. 儿童主要非肿瘤性EB病毒感染相关疾病的诊断和治疗原则建议[J]. 中华儿科杂志, 2016, 54(8): 563-568.
[14] 任高伟, 刘灵, 李明丽, 黄伟, 夏明月. 长疗程抗病毒治疗对传染性单核细胞增多症患儿EBV抑制的影响[J]. 药物生物技术, 2019, 26(6): 516-520.
[15] 周高枫, 张锐沐, 李迟, 陈佳, 田树凤, 邓继岿. 阿昔洛韦治疗传染性单核细胞增多症对发热及住院时间的影响[J]. 儿科药学杂志, 2018, 24(2): 15-17.
[16] 宋美君, 宋哲, 张恒, 张葆青. 儿童传染性单核细胞增多症中西医治疗进展[J]. 中国中西医结合儿科学, 2020, 12(6): 492-496.
[17] Lyu, H.T., Shen, T.T., Zheng, J.S. and Xu, H.Q. (2018) Clinical Effect of Pidotimod Oral Liquid as Adjuvant Therapy for Infectious Mononucleosis. Chinese Journal of Contemporary Pediatrics, 20, 563-566.
[18] Rezk, E., Nofal, Y.H., Hamzeh, A., Aboujaib, M.F., Al Kheder, M.A. and Al Hammad, M.F. (2015) Steroids for Symptom Control in Infectious Mononucleosis. Cochrane Database of Systematic Reviews, No. 11, CD004402. [Google Scholar] [CrossRef] 
[19] 杨颖, 李伟, 高峰. 儿童传染性单核细胞增多症糖皮质激素应用的探讨[J]. 中华临床感染病杂志, 2020, 13(6): 412-418.
[20] Dunmire, S.K., Verghese, P.S. and Balfour, H.H. (2018) Primary Epstein-Barr Virus Infection. Journal of Clinical Virology, 102, 84-92. [Google Scholar] [CrossRef] [PubMed]
[21] 曾静好, 陈江龙, 黎进飞. 30例儿童传染性单核细胞增多症临床分析[J]. 中国医学创新, 2017, 14(3): 126-128.
[22] 彭海燕, 王春燕. 抗病毒治疗对儿童传染性单核细胞增多症的效果分析[J]. 中外医学研究, 2018, 16(2): 124-125.

为你推荐