SIX4基因在肿瘤中的研究进展
Research Progress of SIX4 Gene in Tumor
DOI: 10.12677/ACM.2021.118501, PDF,   
作者: 张帅通：青海大学研究生院，青海 西宁；张易青*：青海大学附属医院病理科，青海 西宁
关键词: SIX家族；SIX4；实体肿瘤；新靶点；miRNA；SIX Family； SIX4； Solid Tumor； New Target； miRNA
摘要: Six同源盒蛋白4 (Six homeobox 4, Six4)是同源盒蛋白(Sinooculis homologous box, SIX)家族中的成员之一，是机体生长发育过程中不可或缺的决定因子，参与胚胎细胞的生长与分化，并在肌细胞的生成及调节中起到重要作用。已有学者研究揭示了，SIX4的表达异常促进了肿瘤的发生、发展进程。此外，SIX4基因可以作为许多微小RNA (miRNA)的靶基因，可以同时作为转录抑制因子和激活剂调控癌细胞启动、增殖和转移，研究SIX4的详细致癌机制在肿瘤形成过程中的作用，能够为临床在肿瘤治疗方面开阔新的视野，将来SIX4基因有望成为新的癌症靶标，用来指导临床肿瘤靶向治疗。本文将从SIX4基因的基本概况、生物遗传学特征、在实体肿瘤中的分子通路及其与miRNA的关系等四个方面来阐述SIX4基因的最新研究进展。
Abstract: SIX Homeobox 4 (Six 4) is a member of the Sinooculis homologous box (SIX) protein family, and is an indispensable determinant in the growth and development of the body. It is involved in the growth and differentiation of embryonic cells, and plays an important role in the generation and regulation of muscle cells. Recent studies have revealed that abnormal expression of Six4 gene promotes the occurrence and progression of tumors. In addition, SIX4 gene can be used as a target gene of variousmirnas, as a transcriptional inhibitor and activator, and regulate the initiation, proliferation and metastasis of cancer cells. Studying the detailed carcinogenic mechanism of SIX4 in the process of tumor formation can open up a new field of vision for clinical treatment of tumor. SIX4 gene in the future is expected to become a potential target and targeted therapy of cancer. In this paper, we will discuss the recent research progress of SIX4 gene from four aspects: the general situation of SIX gene, the biogenetic characteristics, the molecular pathway in solid tumors and the relationship between Six4 gene and microRNA.
文章引用：张帅通, 张易青. SIX4基因在肿瘤中的研究进展[J]. 临床医学进展, 2021, 11(8): 3447-3453. https://doi.org/10.12677/ACM.2021.118501

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