老年肝癌患者行肝癌根治术的临床特点及安全性分析
Clinical Characteristics and Safety Analysis of Radical Resection of Liver Cancer in Elderly Patients with Liver Cancer
摘要: 目的:分析行肝癌根治术的老年肝癌患者的临床特点及安全性。方法:选2019.01~2020.01重庆市合川区中医院外一科收治的85例行肝癌根治术的老年肝癌患者进行研究,根据年龄分为2组,对照组(n = 68,非老年组),试验组(n = 17,老年组),对比一般资料、术后疗效等相关指标。结果:实验组与对照组性别、病程、甲胎蛋白 > 400 μg/L发生率、术中出血量、术后并发症发生率对比无显著差异,P > 0.05。试验组乙型肝炎表面抗原、乙型肝炎病毒及丙型肝炎病毒感染率、肝硬化发生率显著低于对照组,P < 0.05。结论:行肝癌根治术的老年肝癌患者安全性与非老年患者一致,但肝癌根治术可提高老年肝癌患者预期寿命。
Abstract:
Objective: To analyze the clinical characteristics and safety of elderly patients with liver cancer undergoing radical resection of liver cancer. Methods: From January 2019 to January 2020, 85 elderly patients with liver cancer who underwent radical resection of liver cancer and were admitted to the First Department of Chongqing Hechuan Traditional Chinese Medicine Hospital were selected for the study. They were divided into 2 groups according to their age, the control group (n = 68, non-elderly group), and the trial group (n = 17, elderly group), to compare general data, postoperative efficacy and other related indicators. Results: There were no significant differences between the experimental group and the control group in terms of gender, course of disease, incidence of alpha-fetoprotein > 400 μg/L, intraoperative blood loss, and incidence of postoperative complications, P > 0.05. The infection rate of hepatitis B surface antigen, hepatitis B virus and hepatitis C virus, and the incidence of liver cirrhosis in the experimental group were significantly lower than those in the control group, P < 0.05. Conclusion: The safety of elderly liver cancer patients undergoing radical liver cancer surgery is the same as that of non-elderly patients, but radical liver cancer surgery can increase the life expectancy of elderly liver cancer patients.
参考文献
|
[1]
|
Rao, C.V., Asch, A.S. and Yamada, H.Y. (2017) Frequently Mutated Genes/Pathways and Genomic Instability as Prevention Targets in Liver Cancer. Carcinogenesis, 38, 2-11. [Google Scholar] [CrossRef] [PubMed]
|
|
[2]
|
赵姣萍, 许文芳. 预测老年早期肝癌患者术后发生肝衰竭的列线图模型建立[J]. 浙江中西医结合杂志, 2020, 30(9): 767-770.
|
|
[3]
|
武伟, 李国兰, 周洪伟, 等. 行肝癌根治术的老年肝癌患者临床特点及长期预后研究[J]. 中国全科医学, 2016, 19(14): 1663-1666.
|
|
[4]
|
海峡两岸医药卫生交流协会肿瘤防治专家委员会. 肝癌肝切除围手术期管理中国专家共识(2021年版)[J]. 中华肿瘤杂志, 2021, 43(4): 414-430.
|
|
[5]
|
杩奇, 朱瑞萍. 老年原发性肝癌临床特点与病理特点的探讨[J]. 中国现代药物应用, 2020, 14(7): 33-35.
|
|
[6]
|
IARC (2020) Latest Global Cancer Data: Cancer Burden Rises to 19.3 Million New Cases and 10.0 Million Cancer Deaths in 2020.
|
|
[7]
|
中华医学会肝病学分会. 原发性肝癌二级预防共识(2021年版) [J]. 中华肝脏病杂志, 2021, 29(3): 216-226.
|
|
[8]
|
孙雨, 梅苹, 宋晓伟, 等. 320排容积CT灌注成像在36例小肝癌血流灌注特点及病理分化程度评估中的临床价值[J]. 延边大学医学学报, 2019, 42(1): 44-46.
|
|
[9]
|
兆勇, 李井野. 老年肝癌根治性切除术后肝癌复发的高危因素分析[J]. 现代肿瘤医学, 2020, 28(21): 3745-3748.
|
|
[10]
|
Akinyemiju, T., Abera, S., Ahmed, M., et al. (2017) The Burden of Primary Liver Cancer and Underlying Etiologies from 1990 to 2015 at the Global, Regional, and National Level: Results from the Global Burden of Disease Study 2015. JAMA Oncology, 3, 1683-1691. [Google Scholar] [CrossRef] [PubMed]
|
|
[11]
|
何建新, 王永波, 何文平, 张坤, 谭龙. 射频消融术辅助部分肝切除术治疗原发性肝癌的效果及复发率随访研究[J]. 肝胆外科杂志, 2017, 25(2): 126-129.
|
|
[12]
|
王华利, 熊清芳, 杨永峰. 279例老年原发性肝癌临床特点及预后影响因素分析[J]. 实用老年医学, 2017, 31(12): 1135-1137.
|