刺激响应性聚肽纳米材料及其肿瘤药物递送中的应用
Stimu-li-Responsive Polypeptide Nanomaterials and Their Application in Oncology Drug Delivery
摘要: 刺激响应性的聚肽纳米材料具有良好的生物相容性、生物降解性、独特的二级构象以及不同的功能，这些性质使其能够有效增加治疗的效果并减少副作用，所以其在癌症纳米药物方面具有巨大的潜力。本综述就近年来刺激响应性性的聚肽纳米复合物的设计和制备，以及在生物学和临床应用方面的研究进展进行讨论，包括pH、还原和光响应性。此外，我们还讨论了这些刺激响应性聚肽纳米复合物的应用前景，可用于克服癌症纳米药物在体内给药的生物学障碍。因此，需要付出更多的努力来开发第二代刺激响应性性聚肽纳米药物，并用于临床转化和应用。
Abstract: Stimuli-responsive polypeptide nanomaterials has good biocompatibility, biodegradability, unique secondary conformation, and different functions, which can increase the effectiveness of stimulation therapy and reduce side effects, so it has great potential in the field of cancer nanopharmaceuticals. In this review, the recent advances in the design and preparation of stimuli-responsive peptides nanocomplexes, and their biological and clinical applications are reviewed, including pH-, reduction-, and light-responsiveness. In addition, we also discuss the applications and prospects of these stimulus-responsive polypeptide nanocomplexes, which may overcome the biological barriers to the drug delivery of cancer nanodrugs in vivo. Therefore, more efforts are needed to develop the second generation of stimulus-responsive peptide nanomaterials for clinical transformation and application.
文章引用：马宇轩, 于威, 朱吕明, 丁月. 刺激响应性聚肽纳米材料及其肿瘤药物递送中的应用[J]. 纳米技术, 2021, 11(3): 184-190. https://doi.org/10.12677/NAT.2021.113021

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