癫痫与血脑屏障及胶质神经元的关系
Relationship among Epilepsy, Blood Brain Barrier and Glial Neurons
DOI: 10.12677/ACM.2021.118524, PDF,   
作者: 乔治东, 杨光路:内蒙古医科大学附属医院儿科,内蒙古 呼和浩特
关键词: 癫痫血脑屏障炎症Epilepsy Blood Brain Barrier Inflammation
摘要: 癫痫严重损害人类的健康,然而近年来随着人群对抗癫痫药物耐药的不断报道,临床上急需新型抗癫痫药物来控制癫痫发作。而目前的抗癫痫药物大多与离子通道的开放或关闭相关,因此,探究癫痫与血脑屏障及神经组织炎症对发现新的抗癫痫药物有重要作用。
Abstract: Epilepsy seriously damages human health. However, with the continuous reports of antiepileptic drug resistance in recent years, new antiepileptic drugs are urgently needed to control seizures. However, most of the current antiepileptic drugs are related to the opening or closing of ion channels. Therefore, it is important to explore the relationship among epilepsy, blood-brain barrier and inflammation of nerve tissue for the discovery of new antiepileptic drugs.
文章引用:乔治东, 杨光路. 癫痫与血脑屏障及胶质神经元的关系[J]. 临床医学进展, 2021, 11(8): 3589-3591. https://doi.org/10.12677/ACM.2021.118524

参考文献

[1] Ono, S.E., de Carvalho Neto, A., Joaquim, M.J.M., et al. (2019) Mesial Temporal Lobe Epilepsy: Revisiting the Relation of Hippocampal Volumetry with Memory Deficits. Epilepsy & Behavior, 100, Article ID: 106516. [Google Scholar] [CrossRef] [PubMed]
[2] Beamer, E., Fischer, W. and Engel, T. (2017) The ATP-Gated P2X7 Receptor as a Target for the Treatment of Drug-Resistant Epilepsy. Frontiers in Neuroscience, 11, 21. [Google Scholar] [CrossRef] [PubMed]
[3] Zamay, T.N., Zamay, G.S. and Shnayder, N.A. (2019) Nucleic Acid Aptamers for Molecular Therapy of Epilepsy and Blood-Brain Barrier Damages. Molecular Therapy—Nucleic Acids, 19, 157-167. [Google Scholar] [CrossRef] [PubMed]
[4] Wood, H. (2019) Blood-Brain Barrier Pathology Linked to Epilepsy in Alzheimer Disease. Nature Reviews Neurology, 16, 66. [Google Scholar] [CrossRef] [PubMed]
[5] van Vliet, E.A., Aronica, E. and Gorter, J.A. (2015) Blood-Brain Barrier Dysfunction, Seizures and Epilepsy. Seminars in Cell and Developmental Biology, 38, 26-34. [Google Scholar] [CrossRef] [PubMed]
[6] Medina-Ceja, L., Salazar-Sanchez, J.C., Ortega-Ibarra, J., et al. (2019) Connexins-Based Hemichannels/Channels and Their Relationship with Inflammation, Seizures and Epilepsy. International Journal of Molecular Sciences, 20, 5976. [Google Scholar] [CrossRef] [PubMed]
[7] Lee, E., Lee, J. and Kim, E. (2017) Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders. Biological Psychiatry, 81, 838-847. [Google Scholar] [CrossRef] [PubMed]
[8] Wu, Y., Dissing-Olesen, L., MacVicar, B.A., et al. (2015) Microglia: Dynamic Mediators of Synapse Development and Plasticity. Trends in Immunology, 36, 605-613. [Google Scholar] [CrossRef] [PubMed]
[9] Stogsdill, J.A. and Eroglu, C. (2017) The Interplay between Neurons and Glia in Synapse Development and Plasticity. Current Opinion in Neurobiology, 42, 1-8. [Google Scholar] [CrossRef] [PubMed]
[10] Miyamoto, A., Wake, H., Ishikawa, A.W., et al. (2016) Microglia Contact Induces Synapse Formation in Developing Somatosensory Cortex. Nature Communications, 7, Article No. 12540. [Google Scholar] [CrossRef] [PubMed]
[11] Allen, N.J. and Eroglu, C. (2017) Cell Biology of Astrocyte-Synapse Interactions. Neuron, 96, 697-708. [Google Scholar] [CrossRef] [PubMed]
[12] Andoh, M., Ikegaya, Y. and Koyama, R. (2019) Synaptic Pruning by Microglia in Epilepsy. Journal of Clinical Medicine, 8, 2170. [Google Scholar] [CrossRef] [PubMed]
[13] Campbell, S.C., Munoz-Ballester, C., Chaunsali, L., et al. (2020) Potassium and Glutamate Transport Is Impaired in Scar-Forming Tumor-Associated Astrocytes. Neurochemistry International, 133, Article ID: 104628. [Google Scholar] [CrossRef] [PubMed]