异位妊娠药物治疗的研究进展

Research Progress of Drug Therapy for Ectopic Pregnancy

摘要: 异位妊娠是指发生在宫外的妊娠，又被称为宫外孕。是妇科常见的疾病，发病频率较高，同时存在较高的死亡风险。近年来，随着此病早期诊断率大大提高，药物保守治疗成为更多患者的选择，但传统药物保守治疗即肌注甲氨蝶呤杀胚缺点较多。所以探求一种毒性小、治疗周期短，普适的药物保守治疗异位妊娠的方法，成为国内外学者关注的热点。本文着重对三种异位妊娠药物保守治疗的新方法加以概述，即靶向集落刺激因子-1受体信号、来曲唑(芳香化酶抑制剂)、无水乙醇绒毛靶向治疗异位妊娠。

Abstract: Ectopic pregnancy refers to pregnancy that occurs outside the uterus. It is a common gynecological disease with high incidence and high risk of death. In recent years, as the early diagnosis rate of the disease has been greatly improved, drug conservative treatment has become the choice for more patients, but there are many disadvantages of traditional drug conservative treatment, i.e. intramuscular methotrexate embryo killing. Therefore, to explore a less toxic, short treatment cycle and universal drug conservative treatment of ectopic pregnancy has become the focus of scholars at home and abroad. This article focuses on an overview of three new methods for conservative treatment of ectopic pregnancy with drugs, namely, targeted colony stimulating factor-1 receptor signal, letrozole (aromatase inhibitor), and absolute ethanol villi targeted therapy for ectopic pregnancy.