遵义地区女性儿童性早熟的流行特征及出生情况、遗传因素的调查研究

Investigation and Research on the Epidemic Characteristics, Birth Status and Genetic Factors of Female and Childhood Sexual Precocity in Zunyi District

摘要: 目的：调查研究遵义地区女性儿童性早熟的流行特征与出生情况、遗传因素。方法：选取我院儿童生长发育门诊、儿童保健门诊以及住院部在2019年1月至2020年12月收治的200例女性中枢性早熟儿童作为研究组，并选取相同时期在我院门诊体检的正常女性儿童200例作为参照组，回顾分析研究主体的临床资料，实施骨龄、雌二醇、卵泡刺激素、睾酮、黄体生成素等的临床检验，对两组受检者展开调查研究，掌握女性儿童性早熟流行特征，研究其相关因素。结果：在身高、体质量、骨龄、雌二醇、卵泡刺激性素、睾酮、黄体生成素对比方面，研究组各项检查指标与参照组差异明显，组间有统计学差异，P < 0.05；经单因素分析发现，女性儿童性早熟可能与家庭周围环境受污染、母亲初潮年龄、父母关系是否和谐、是否存在性早熟家族史、喜欢看情感类节目或小说、食用西式快餐、食用营养丰富的滋补品、食用含有色素与防腐剂食品、食用高蛋白食品等存在一定联系，组间对比有统计学差异，P < 0.05；此次调查研究中发现，女性儿童性早熟的危险因素为喜欢看情感类节目或小说、食用西式快餐、食用营养丰富的滋补品、食用含有色素与防腐剂食品、食用高蛋白食品，组间对比P < 0.05，表示差异有统计学意义。结论：影响女性儿童性早熟的因素许多，需要为女性儿童构建健康的成长环境，做好科学饮食与抚育，才能降低女性儿童性早熟的发生概率。

Abstract: Objective: To investigate and study the epidemiological characteristics, birth conditions and genetic factors of precocious puberty among female children in Zunyi area. Methods: 200 cases of female central precocious puberty children admitted from January 2019 to December 2020 in our hospital’s child growth and development clinic, children’s health clinic, and inpatient department were selected as the research group, and the normal outpatient physical examinations in our hospital during the same period were selected. 200 cases of female children were used as the reference group to review and analyze the clinical data of the main body of the study, implement clinical tests on bone age, estradiol, follicle stimulating hormone, testosterone, luteinizing hormone, etc., conduct investigation and research on the two groups of subjects to master female children. The epidemiological characteristics of precocious puberty, study its related factors. Results: In terms of height, body weight, bone age, estradiol, follicle stimulating hormone, testosterone, and luteinizing hormone, the inspection indicators of the study group and the reference group were significantly different, and there were statistical differences between the groups, P < 0.05; single factor analysis found that female children’s precocious puberty may be related to the pollution of the family’s surrounding environment, the mother’s age at menarche, whether the parental relationship is harmonious, whether there is a family history of precocious puberty, like watching emotional programs or novels, eating Western-style fast food, eating nutritious food Tonics, foods containing pigments and preservatives, and high-protein foods are related to a certain degree. There are statistical differences between the groups, P < 0.05; this investigation found that the risk factor for precocious puberty in female children is to look at emotions. For similar programs or novels, eating Western-style fast food, eating nutritious supplements, eating foods containing pigments and preservatives, eating high-protein foods, the comparison between the groups P < 0.05, indicating that the difference is statistically significant. Conclusion: There are many factors that affect precocious puberty in women and children. It is necessary to build a healthy growth environment for women and children, and to do a good job of scientific diet and nurturing in order to reduce the probability of precocious puberty in women and children.