男性痛风患者血清尿酸水平与载脂蛋白B的关系研究

Study on the Relationship between Serum Uric Acid Level and Apolipoprotein B in Male Patients with Gout

摘要: 目的：探讨男性痛风(Gout)患者血清尿酸(SUA)水平与载脂蛋白B (ApoB)的关系。方法：回顾性选取2019年1月1日至2021年3月31日于青岛大学附属医院内分泌与代谢性疾病科就诊的住院患者以及门诊患者，纳入符合条件的男性痛风患者73例。根据《中国高尿酸血症与痛风诊疗指南(2019)》要求，将患者分为SUA达标组(19例)和SUA升高组(54例)，比较组间差异。采用Pearson相关分析SUA和ApoB的相关性，利用logistic回归模型进行相关危险因素分析。结果：与SUA达标组相比，SUA升高组ApoB的平均水平升高，差异有统计学意义(P < 0.05)。Pearson相关性分析显示ApoB与SUA呈正相关。单因素logistic回归分析显示，男性痛风患者SUA水平升高是ApoB的危险因素(OR = 0.986, 95% CI 0.979~0.993, P < 0.001)；当校正年龄、空腹血糖(FBG)、身体质量指数(BMI)等因素后，两者关系仍然成立。结论：男性痛风患者SUA与ApoB相关，当SUA水平升高时，可导致ApoB水平升高。

Abstract: Objective: To explore the relationship between serum uric acid (SUA) and apolipoprotein B (Apo B) in male gout patients. Methods: A total of 73 eligible male patients with gout were retrospectively selected from the inpatients and outpatients who were admitted to the Department of Endocrinology and Metabolism Diseases of the Affiliated Hospital of Qingdao University on January 1, 2019 and March 31, 2021. According to the requirements of the “Guidelines for the Diagnosis and Treatment of Hyperuricemia and Gout in China (2019)”, patients were divided into the SUA standard group (19 cases) and the SUA elevated group (54 cases), and the differences between the groups were compared. Pearson correlation analysis was used to analyze the correlation between SUA and ApoB, and logistic regression model was used to analyze related risk factors. Results: Compared with the SUA level up to standard group, the average level of ApoB in the high SUA group increased, and the difference was statistically significant (P < 0.05). Pearson correlation analysis showed that ApoB was positively correlated with SUA. Univariate logistic regression analysis showed that elevated SUA level was a risk factor for ApoB in male patients with gout (OR = 0.986, 95% CI 0.979~0.993, P < 0.001). After adjusting for age, fasting blood glucose (FBG), body mass index (BMI) and other factors, the relationship still held. Conclusion: SUA is related to ApoB in male patients with gout. When the level of SUA increases, it can cause the level of ApoB to increase.