欧米伽-3脂肪酸对轻度认知障碍患者的蒙特利尔认知评估量表评分的影响

Effect of Omega-3 Fatty Acids on the Score of Montreal Cognitive Assessment Scale in Patients with Mild Cognitive Impairment

摘要: 目的：探讨欧米伽-3脂肪酸对轻度认知障碍患者的蒙特利尔认知评估量表评分的影响。方法：将60例轻度认知障碍(MCI)患者随机分配到欧米伽-3脂肪酸鱼油组(每日包含720 mg EPA和480 mg DHA)和安慰剂组，使用蒙特利尔认知评估量表(MoCA)对MCI进行认知功能测评；用气象色谱仪发分析血浆EPA及DHA含量。结果：干预8周后，鱼油组8周后MoCA评分[23.5 (21.50, 25.25)]较基线评分[23 (20.25, 24)]无统计学差异(P = 0.256)，但量表评分有提高。安慰剂组8周较基线评分无改善。结论：欧米伽-3多不饱和脂肪酸鱼油胶囊可以改善MCI患者的蒙特利尔认知评估量表评分，进一步的研究应进行更大的样本量，更大的欧米伽–脂肪酸剂量和更长的随访时间来进一步明确结论。

Abstract: Objective: To investigate the effect of omega-3 fatty acids on the score of Montreal cognitive assessment scale in patients with mild cognitive impairment. Methods: 60 patients with mild cognitive impairment (MCI) were randomly assigned to omega-3 fatty acid fish oil group (including 720 mg EPA and 480 mg DHA daily) and placebo group. The cognitive function of MCI was assessed by Montreal Cognitive Assessment scale (MoCA), and the contents of plasma EPA and DHA were analyzed by meteorological chromatograph. Results: After 8 weeks of intervention, there was no significant difference in the MoCA score between the fish oil group and the baseline score [23.5 (21.50, 25.25)] vs [23 (20.25, 24)], (P = 0.256), but the score of the scale was improved. There was no improvement in the placebo group compared with the baseline score at 8 weeks. Conclusion: Omega-3 polyunsaturated fatty acid can improve the score of Montreal cognitive assessment scale in patients with MCI. Further studies should be conducted with larger sample size, larger dose of omega-fatty acid and longer follow-up time to further confirm the conclusion.