血清锌α2-糖蛋白与动脉粥样硬化的研究进展
Research Progress of Serum Zinc α 2-Glycoprotein and Atherosclerosis
摘要: 血清锌α2-糖蛋白(Serum zinc α2-glycoprotein, ZAG)是一种可溶性糖蛋白,通过对ZAG的深入研究,发现ZAG不仅参与肥胖、能量平衡的调控,对脂代谢、血管代谢中的调节作用也很重要,它参与糖尿病、肾病、肥胖等多种疾病的发生发展,在心血管病(Cardiovascular Disease,CVD)方面尤其是动脉粥样硬化(Atherosclerosis,AS)的形成,近些年成为研究的热点。本文对ZAG与AS关系做一综述。
Abstract: Serum zinc α2-glycoprotein (ZAG) is a soluble glycoprotein. Through in-depth studies on ZAG, it is found that ZAG is not only involved in the regulation of obesity and energy balance, but also plays an important role in the regulation of lipid metabolism and vascular metabolism. It is involved in the occurrence and development of diabetes, kidney disease, obesity and other diseases, cardiovascular disease, especially the formation of atherosclerosis (AS), which has become a research hotspot in recent years. The relationship between ZAG and AS is reviewed in this paper.
文章引用:陈芳, 李飞. 血清锌α2-糖蛋白与动脉粥样硬化的研究进展[J]. 临床医学进展, 2021, 11(8): 3801-3805. https://doi.org/10.12677/ACM.2021.118558

参考文献

[1] 王增武, 胡盛寿. 《中国心血管健康与疾病报告2019》要点解读[J]. 中国心血管杂志, 2020, 25(5): 401-410.
[2] Tzanavari, T., Bing, C. and Trayhurn, P. (2007) Postnatal Expression of Zinc-α2-Glycoprotein in Rat White and Brown Adipose Tissue. Molecular and Cellular Endocrinology, 279, 26-33. [Google Scholar] [CrossRef] [PubMed]
[3] Burgi, W. and Schmid, K. (1961) Preparation and Properties of Zinc-α2-Glycoprotein of Normal Human Plasma. Journal of Biological Chemistry, 236, 1066-1074. [Google Scholar] [CrossRef
[4] Ueyama, H., Deng, H.X. and Ohkubo, I. (1993) Molecular Cloning and Chromosomal Assignment of the Gene for Human Zinc-α2-Glycoprotein. Biochemistry, 32, 12968-12976. [Google Scholar] [CrossRef] [PubMed]
[5] Ueyama, H., Niwa, M., Tada, T., Sasaki, M. and Ohkubo, I. (1991) Cloning and Nucleotide Sequence of a Human Zinc-α2-Glycoprotein cDNA and Chromosomal Assignment of Its Gene. Biochemical & Biophysical Research Communications, 177, 696-703. [Google Scholar] [CrossRef
[6] Rolli, V., Radosavljevic, M., Astier, V., Macquin, C., Castan-Laurell, I., Visentin, V., et al. (2007) Lipolysis Is Altered in MHC Class I Zinc-α2-Glycoprotein Deficient Mice. FEBS Letters, 581, 394-400. [Google Scholar] [CrossRef] [PubMed]
[7] 葛均波. 动脉粥样硬化研究概述[J]. 中西医结合心脑血管病杂志, 2015(6): 705-707.
[8] 王怡茹, 张一凡, 刘萍. 免疫细胞参与动脉粥样硬化炎症反应的研究进展[J]. 中国医药导报, 2020, 17(35): 46-48+52.
[9] 王中群, 李丽华, 杨永宗. 遗传因素在动脉粥样硬化发生与防治中的作用[J]. 中国动脉硬化杂志, 2009(7): 621.
[10] 彭红. 血清锌α2糖蛋白与动脉粥样硬化的相关性研究[D]: [硕士学位论文]. 泸州: 西南医科大学, 2017: 1-73.
[11] Leal, V.O., Lobo, J.C., Stockler-Pinto, M.B., Farage, N.E., Abdalla, D.S., Leite Jr., M. and Mafra, D. (2012) Is Zinc-α2-Glycoprotein a Cardiovascular Protective Factor for Patients Undergoing Hemodialysis? Clinica Chimica Acta, 413, 616-619. [Google Scholar] [CrossRef] [PubMed]
[12] 陈桢, 高丽萍, 苏红. 血清锌-α2-糖蛋白在维持性血液透析患者冠状动脉钙化诊断中的价值[J]. 心肺血管病杂志, 2020, 39(10): 1208-1212.
[13] Zhu, H.J., Dong, C.X., Pan, H., Ping, X.-C., Li, N.-S., Dai, Y.-F., et al. (2012) rs4215 SNP in Zinc-α2-Glycoprotein Gene Is Associated with Obesity in Chinese North Han Population. Gene, 500, 211-215. [Google Scholar] [CrossRef] [PubMed]
[14] 董彩霞. ZAG基因多态性与超重肥胖的相关性研究[D]: [博士学位论文]. 北京: 北京协和医学院, 2009: 1-54.
[15] Liu, M., Zhu, H., Zhai, T., Pan, H., Wang, L., Yang, H., et al. (2019) Serum Zinc-α2-Glycoprotein Levels Were Decreased in Patients with Premature Coronary Artery Disease. Frontiers in Endocrinology, 10, Article No. 197. [Google Scholar] [CrossRef] [PubMed]
[16] Liu, M., Zhu, H., Dai, Y., Pan, H., Li, N., Wang, L., et al. (2018) Zinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice. Frontiers in Physiology, 9, Article No. 62. [Google Scholar] [CrossRef] [PubMed]