中药多糖免疫调节作用机制的研究进展
Recent Advances on Immune Regulatory Mechanism of Polysaccharides from Traditional Chinese Medicine
DOI: 10.12677/PI.2021.105036, PDF,    科研立项经费支持
作者: 陆 艳：浙江中医药大学第一临床医学院，浙江 杭州；王丝雨, 何 玲, 蒋科澎, 周芳美*：浙江中医药大学医学技术学院，浙江 杭州
关键词: 中药多糖；免疫调节；免疫细胞；受体；信号通路；Traditional Chinese Medicine Polysaccharides； Immunological Regulation； Immune Cell； Receptor； Signaling Pathway
摘要: 多糖是人体生命活动中不可缺少的生物大分子物质，具有免疫调节、抗肿瘤、抗氧化等多种生物活性，其中中药多糖对机体的免疫调节有广泛的应用范围和重要的研究意义。近年来，中药多糖由于其对人体有免疫调节活性且毒副作用小、疗效确切、物质来源广泛，而受到世界医学科学研究者的青睐。因此，中药多糖的免疫调节作用一直是研究的热点领域。本文就中药多糖免疫调节的作用机制加以综述，并从免疫细胞、受体和免疫信号通路方面系统地阐明多糖的免疫调节作用机制，有助于多糖类药物的开发应用和研究。
Abstract: Polysaccharide is an indispensable biomacromolecule in life, which has a variety of biological activities, such as immune regulation, anti-tumor, anti-oxidation, and so on. Among them, polysaccharide of Traditional Chinese medicine has a wide range of application and important significance to the immune regulation of the body. In recent years, traditional Chinese medicine polysaccharides are favored by medical researchers all over the world because of their immunomodulatory activity, less toxic and side effects, exact curative effect, and wide material sources. Therefore, the immunomodulatory effect of traditional Chinese medicine polysaccharides has always been a hot research field. This paper expounds on the immune promoting and immunosuppressive effects of traditional Chinese medicine polysaccharides, and summarizes the effects of traditional Chinese medicine on immune cells, receptors, and immune signal pathways, which is helpful to clarify the internal mechanism of traditional Chinese medicine polysaccharides immunomodulatory effect, so as to provide a new theoretical basis for the discovery and development of new polysaccharide immunomodulatory drugs in the future.
文章引用：陆艳, 王丝雨, 何玲, 蒋科澎, 周芳美. 中药多糖免疫调节作用机制的研究进展[J]. 药物资讯, 2021, 10(5): 283-289. https://doi.org/10.12677/PI.2021.105036

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