超重和肥胖与乳腺癌的发病及临床病理相关性研究

Study on the Correlation between Overweight and Obesity and Breast Cancer Morbidity and Clinical Pathology

摘要: 目的：探究肥胖与乳腺癌病理类型的相关性，进一步阐明病理状况，包括：组织学类型，免疫组化ER、PR、Her-(2)、Ki-67情况，SBR分级，TNM分期等与肥胖的相关性，为乳腺癌的临床诊治及预防提供证据。方法：回顾性分析2020年1月到2021年8月就诊于延大附院，通过手术标本或B超引导下穿刺活检标本的病理诊断为乳腺癌的127例患者，充分收集患者的基本信息，手术标本病理情况，免疫组化情况，按照体质指数BMI分为BMI < 24 kg/m³为正常体重组，BMI ≥ 24 kg/m³为超重肥胖组，探究两组患者的肥胖情况与临床病理特征的相关性。结果：浸润性乳腺癌组的BMI平均值为23.23 ± 3.402 Kg/m²，明显高于非浸润性乳腺癌组患者的BMI平均值2153 ± 1.275 Kg/m²，且差异有统计学意义(P < 0.05)。ER、PR、Her-2及Ki-67状态、是否有淋巴结转移、SBR分级、TNM分期、分子类型及受教育程度在正常体重组与超重肥胖组间无差异，与未绝经人群相比，绝经后人群中BMI较大者占有更多比例，差异有统计学意义(P < 0.05)。

Abstract: Objective: To explore the correlation between obesity and pathological types of breast cancer, and to further clarify the pathological conditions, including histological types, immunohistochemistry ER, PR, Her-(2), KI-67, SBR grade, TNM stage, and the correlation with obesity, so as to provide evidence for the clinical diagnosis, treatment and prevention of breast cancer. Methods: Retrospective analysis in January 2020 to August 2021 in the delay of establishing affiliated hospital, through the surgical specimen or B ultrasound guided puncture biopsy specimens of the pathological diagnosis of 127 cases of breast cancer patients, sufficient to collect the basic information of patients, surgical specimens of pathological conditions, immunohistochemical, according to body mass index (BMI) is divided into BMI < 24 kg/m³ for normal weight group, BMI ≥ 24 kg/m³ was considered as overweight and obesity group, and the correlation between obesity and clinicopathological features in the two groups was investigated. Results: The mean BMI of invasive breast cancer group was 23.23 ± 3.402 Kg/m², which was significantly higher than that of non-invasive breast cancer group (2153 ± 1.275 Kg/m²), and the difference was statistically significant (P < 0.05). ER, PR, HER-2 and KI-67 status, lymph node metastasis, SBR grade, TNM stage, molecular type and education level showed no difference between the normal weight group and the overweight and obese group. Compared with the pre-menopausal group, the proportion of people with higher BMI in the postmenopausal group was more, and the difference was statistically significant (P < 0.05).