慢性阻塞性肺疾病急性加重期预后指标的探讨

Discussion of the Prognostic Index of Acute Aggravation of COPD Disease

摘要: 慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是一种以持续的呼吸道症状和气流受限为特征的慢性疾病，其气流受限多呈进行性且不可逆性发展。慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease, AECOPD)是指以呼吸道症状加重为特征的临床事件，其症状变化程度超出日常变异范围，需要改变药物治疗方案。AECOPD是造成死亡的主要原因，住院时间延长、死亡率上升都会增加社会负担，并对生活质量、肺功能和疾病进展产生负面影响。本文综述了临床上常见指标作一分析，为以后AECOPD诊断、治疗及预后发挥更大的作用。

Abstract: Chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD) is a chronic disease characterized by persistent respiratory symptoms and restricted airflow that is more progressive and irreversibly develops. Period of acute exacerbation of chronic obstructive pulmonary disease (acute exacerbation of chronic obstructive pulmonary disease, AECOPD) is a clinical event characterized by aggravation of respiratory symptoms with the degree of symptom changes beyond the range of daily variation and requires changes in drug regimens. Acute aggravation of COPD is the major cause of death, with prolonged hospitalization and increased mortality all increasing social burden and negatively affecting quality of life, lung function and disease progression. This paper reviews an analysis of common clinical indicators to play a greater role in future AECOPD diagnosis, treatment and prognosis.